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Cancer Biology

A section of Biology (ISSN 2079-7737).

Section Information

The Cancer Biology Section aims to advance our understanding of cancer as a complex and dynamic disease in which cancer cells interact and co-evolve with the tumor microenvironment and host physiology, in either the untreated state or in response to therapeutic pressures.

While normal cells follow strictly regulated processes of growth, division, and death, these controls fail in cancer. Our understanding of the (patho)biology of cancer has evolved over time. The transformation of a normal cell into a cancer cell occurs in several steps, including the maintenance of proliferative signaling, the evasion of growth suppressors, resistance to cell death, the facilitation of replicative immortality, the induction of angiogenesis, and the activation of invasion and metastasis. These changes often take place due to genetic mutations. In addition, recent advances have shed light on the role of the tumor microenvironment, interactions with the immune system, and epigenetic changes.

We welcome submissions of original research, reviews, technical and methodological advances, and brief communications in all areas of cancer research. Particular emphasis is placed on studies of tumor heterogeneity and evolution, the tumor microenvironment, immune evasion and rejuvenation, metabolic fitness and reprogramming, metastasis, preclinical modeling, biomarker discovery, and early detection.

The overall aim of this section is to support the publication of research that advances the field of cancer biology. Understanding cancer at the biological level is key to developing better diagnostic tools, treatments, and, ultimately, cures.