Background/Objectives: High-throughput molecular profiling identifies potential determinants of treatment resistance, but the extent to which these discoveries support reversal of acquired resistance or enhanced treatment sensitivity in oral squamous...
The treatment landscape for metastatic hormone-sensitive prostate cancer continues to evolve, with systemic treatment being the mainstay of current treatment. Prognostic and predictive factors such as tumour volume and disease presentation have been...
Purpose: This umbrella review focused on evaluating the efficacy and adverse events of the metastatic hormone-sensitive prostate cancer patients receiving any treatment regimens, including ADT alone or combination treatments. Methods: This study cond...
The treatment landscape of metastatic hormone-sensitive prostate cancer (mHSPC) has transformed significantly with the advent of triplet therapy involving androgen deprivation therapy (ADT), docetaxel, and androgen receptor signalling inhibitors (ARS...
Objectives: Spondyloarthritis (SpA) is a chronic inflammatory arthritis that mainly affects the sacroiliac joints and spine. Despite effective biological treatments, persistent pain is common in SpA patients, potentially due to central sensitization...
In disciplines such as epidemiology, economics, and public health, inference and estimation of heterogeneous treatment effects (HTE) are critical. This approach helps reveal differences in treatment effect estimates between subgroups, which supports...
This study calculates the carbon footprint of chemical coagulants and operational energy for residential and industrial (whey digestion) wastewater treatment using ReCiPe 2016 methodology within a clearly defined system boundary from cradle to gate....
Introducing [177Lu]Lu-PSMA-617 into metastatic hormone-sensitive prostate cancer (mHSPC) raises questions about patient selection and treatment sequencing. This non-systematic narrative review examines PSMAddition alongside evidence on alternative tr...
Although most of the early research studies on fractional-order systems were based on the Caputo or Riemann–Liouville fractional-order derivatives, it has recently been proven that these methods have some drawbacks. For instance, kernels of these met...
Background/Objectives: Treatment intensification with novel hormonal therapies is now standard in metastatic hormone-sensitive prostate cancer (mHSPC), but real-world patients are often more heterogeneous than those included in pivotal trials. This s...
Steel wire rods are essential for manufacturing high-strength steel tire cords. Yet, the presence of residual copper (Cu) in recycled steel can cause grain-boundary sensitization, embrittlement, and deterioration of the mechanical performance of the...
A major challenging problem facing effective ovarian cancer therapy is cisplatin resistance. Re-sensitization of cisplatin-resistant ovarian cancer cells to cisplatin (CDDP) has become a critical issue. Curcumin (CUR), the most abundant dietary polyp...
Introduction: Over the past decade, the treatment of metastatic castration-sensitive prostate cancer (mCSPC) has changed significantly. Current guidelines suggest the use of androgen deprivation therapy (ADT) plus an additional systemic therapy, rega...
Multidrug-resistant (MDR) Pseudomonas aeruginosa infections pose a serious health threat. Bacteriophage–antibiotic combination therapy is a promising candidate for combating these infections. A 5-phage P. aeruginosa cocktail, PAM2H, was tested in com...
Geriatric patients in various outpatient department (OPDs) have been found to agonize from elder abuse and neglect (EAN). Such suffering imposes depressive states within individuals, which in turn affects treatment compliance. The objective of this s...
Improper thermal cycles on duplex stainless steels can lead to the formation of detrimental phases or alter the proportion of ferrite and austenite phases, thus influencing the material’s mechanical properties and corrosion resistance. Therefor...
Formaldehyde is a well-known, ubiquitous chemical agent and a widely used skin sensitizer. There are reports of cases of systemic and localized allergic reactions attributed to formaldehyde (or formaldehyde-containing resins), which can occur during...
Type Al-Zn-Mg alloy has a wide ranges of application in vehicles, but corrosion resistance and mechanical properties of this alloy after heat treatment or heat straightening limits its utilization. This paper investigates the effect of quenching cond...
Given the limited efficacy of current interventions and the complexity of chronic pain, identifying perpetuating factors is crucial for uncovering new mechanistic pathways and treatment targets. The oral and gut microbiome has emerged as a potential...
With the accelerating urbanization process, traditional wastewater treatment plants are facing dual challenges of high energy consumption and high carbon emissions. To address the current research gaps in studies regarding the overlooked synergistic...
Allergy risk has become a significant public health issue with increasing prevalence. Exclusive breastfeeding is recommended for the first six months of life, but this recommendation is poorly adhered to in many parts of the world, including the Midd...
Background: There are concerns with inappropriate prescribing of antibiotics in hospitals especially broad spectrum in Pakistan and the subsequent impact on antimicrobial resistance rates. One recognized way to reduce inappropriate prescribing is for...
Background: Vulvodynia is defined as a chronic idiopathic vulvar pain condition. This study aimed to investigate the effect of central sensitization on the prognosis of neuromodulator treatment for vulvodynia. Method: A total of 105 patients with vul...
Overcoming resistance is one of the most challenging features in current anticancer therapy. Autophagy is a cellular process that confers resistance in some advanced tumors, since it enables cancer cells to adapt to stressful situations, such as anti...
The polyphenolic flavonoid Baicalein has been shown to trigger suicidal death or apoptosis of tumor cells and is thus considered for the prevention and treatment of malignancy. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis...
Thermal interface materials (TIMs) are very crucial for better heat-transfer in electronics working as an interfacial connection between heat generators and heat sinks. This study is focused on the pressure-sensitive acrylic adhesive tape reinforced...
Immunotherapy harnessing immune functions is a promising strategy for cancer treatment. Tumor sensitization is one approach to enhance tumor cell susceptibility to immune cell cytotoxicity that can be used in combination with immunotherapy to achieve...
The organic residues on titanium(IV) oxide may be a significant factor that decreases the efficiency of dye-sensitized solar cells (DSSC). Here, we suggest the UV-ozone cleaning process to remove impurities from the surface of TiO2 nanoparticles befo...
Post-traumatic trigeminal neuropathy (PTTN) is a sensory abnormality caused by injury to the trigeminal nerve during orofacial surgery. However, existing analgesics are ineffective against PTTN. Abnormal microglial activation in the caudal part of th...
Experimental evidence supports the counterintuitive notion that rapid eradication of pathogens within a host, infected with both drug-sensitive and -resistant malaria parasites, can actually accelerate the evolution of drug-resistant pathogens. This...
Endometrial cancer (EC) is increasingly recognized as a heterogeneous disease, yet current treatment strategies often fail to explain why tumors with similar molecular profiles respond differently or develop resistance. This gap points to regulatory...
The high toxicity of hydrogen sulfide combined with poor sensitivity at room operating temperature urge for the development of new sensitive materials for sensors complying with this requirement, as well as a fast response and low cost. In this work,...
In this work, the sensitivity zone of microstructure and temperature for precipitation-strengthened nickel-based superalloys, used for turbine applications in aero-engines, has been firstly established. Heat treatment experiments with different solut...
Thermal treatments of milk induce changes in the properties of milk whey proteins. The aim of this study was to investigate the specific changes related to nutrients in the whey proteins of dairy cow milk after pasteurization at 85 °C for 15 s or ult...
In this paper, we present an integrative framework based on Evolutionary Stackelberg Game Theory to model the strategic interaction between a physician, acting as a rational leader, and a heterogeneous population of treatment-sensitive and treatment-...
Multiwalled carbon nanotubes (MWCNTs) have excellent electrical conductivity and good chemical stability, and are used as counter electrodes in dye-sensitized solar cells (DSSCs). The counter electrodes collect electrons from the external circuit and...
Objectives: If questionnaires contributing to the diagnosis of dry eye disease are to be recommended as alternatives to existing questionnaires, they must be comparable, with similar repeatability and treatment sensitivity. Comparability was thus exa...
Cell adhesion to stromal support and the associated intracellular signaling are central to drug resistance, therefore blocking both has been effective in increasing drug sensitization in leukemia. The stromal Ser/Thr protein kinase C (PKC) has been f...
The management of locally advanced head and neck squamous cell carcinoma (HNSCC) with Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor (EGFR), achieves only moderate response rates, and clinical trials that evaluated EG...
With the advancement of science and modern medical technology, more and more medical materials and implants are used in medical treatment and to improve human life. The safety of invasive medical materials and the prevention of infection are graduall...
Tuberculosis (TB), caused by Mycobacterium tuberculosis is one of the treacherous infectious diseases of global concern. In this paper, we consider a deterministic model of TB infection with the public health education and hospital treatment impact....
Despite the availability of effective treatment, tuberculosis (TB) remains a major public health problem worldwide. Related factors that promote continued transmission include treatment failure, residual infectiousness during treatment, environmental...
The influence of incorporation of the dopants with proton-acceptor properties into perfluorosulfonic acid cation exchange membranes (MF-4SC and Nafion), and their treatment conditions on the characteristics of Donnan potential (DP)-sensors (analytica...
In response to the European Union’s revised Urban Wastewater Treatment Directive, which mandates enhanced monitoring and advanced treatment of micropollutants, this study was conducted. It took place within the Coastal Landscape Park (CLP), a N...
Breast cancer is a heterogeneous disease, and treatment resistance remains a critical challenge. Claudin-8 (CLDN8), a tight junction protein, has emerged as a potential indicator of therapeutic response and prognosis in breast cancer patients. In thi...
Endometriosis is a complicated, estrogen-dependent gynecological condition with a high morbidity rate. Pain, as the most common clinical symptom of endometriosis, severely affects women’s physical and mental health and exacerbates socioeconomic...
CAP is an ionized gas generated under atmospheric pressure conditions. Due to its reactive chemical components and near-room temperature nature, CAP has promising applications in diverse branches of medicine, including microorganism sterilization, bi...
This study evaluated the effectiveness of an electronic system for managing individuals with drug-sensitive pulmonary tuberculosis in the Kyrgyz Republic. This cohort study used programmatic data. The study included people registered on the paper-bas...
Background/objectives: Non-small cell lung cancer and pleural mesothelioma are among the most lethal and therapy-resistant tumors in humans. These tumors are diagnosed late, frequently present pleural effusion and develop drug resistance, and the tre...
Central sensitisation is defined as a multifactorial etiopathogenetic condition involving an increase in the reactivity of nociceptive neurons and alterations in pain transmission and perception in the central nervous system. Patients may present wit...
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