Neurofibromatosis type 1 (NF1) is a complex, multisystem, genetic disorder caused by germline NF1 variants that predispose affected individuals to tumors of the nervous system. With the identification of the NF1 gene in the late 1980s and the elucida...
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disorder marked by cerebellar dysfunction, ataxic gait, and progressive motor impairments. SCA2 is caused by the pathologic expansion of CAG repeats in the ataxin-2 (ATXN...
In this paper, the throughput and energy efficiency of an unlicensed machine type communications network is studied. If an outage event happens in the network, there is a possibility for packet retransmission in order to obtain a lower error probabil...
The demand for extensive data rates in dense-traffic wireless networks has expanded and needs proper controlling schemes. The fifth generation of mobile communications (5G) will accommodate these massive communications, such as massive Machine Type C...
Type 2 diabetes (T2D) is a complex disorder that is caused by a combination of genetic, epigenetic, and environmental factors. High-throughput approaches have opened a new avenue toward a better understanding of the molecular bases of T2D. A genome-w...
Background: Accurate human leukocyte antigen (HLA) genotyping is a critical step in the implementation of neoantigen peptide-based cancer immunotherapy. Existing computational tools for HLA genotyping using high-throughput sequencing data often lack...
Background: Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by heterozygous germline NF1 gene mutations that predispose patients to developing plexiform neurofibromas, which are benign but often disfiguring tumors of the peripheral...
Cytochrome P450s (CYPs) play an integral role in drug and xenobiotic metabolism in humans, and thus, understanding CYP inhibition and/or activation by new therapeutic candidates is an important step in the drug development process. Ideally, CYP inhib...
Agarwood, a highly valuable resin/wood combination with diverse pharmacological activities but scarce supply, has a long history of being used as a medicine in several medical systems. Grafted Kynam agarwood (GKA) has been cultivated successfully rec...
Forest types vary in root exudation, litter quality, microclimate, and soil properties, but their impact on microbial community assembly, especially when mixed with elevation, is unclear. Using high-throughput sequencing, phylogenetic null-model anal...
The Yellow River floodplain relies on plantations for ecological restoration, yet the key factors influencing soil microbial communities remain poorly elucidated. In this study, we investigated soil microbial communities under four representative sta...
The toxicity of the copper oxide nanoparticles (CuO NP) has been attributed to the so-called “Trojan horse”-type mechanism, relying on the particle uptake and extensive intracellular release of copper ions, due to acidic pH in the lysosom...
Amylin is a pancreatic peptide hormone that regulates glucose homeostasis but also aggregates to form islet amyloid in type-2 diabetes. Given its role in both health and disease, there is renewed interest in proteolytic degradation of amylin by insul...
To reveal the effect of the interactions between soil depth and different land use types on soil nutrients and soil bacterial communities in a karst area, fifty soil samples from five different karst land use types in Huajiang town, Guizhou province,...
Type 2 diabetes (T2D) is a metabolic disorder characterized by loss of pancreatic β-cell function, decreased insulin secretion and increased insulin resistance, that affects more than 537 million people worldwide. Although several treatments are...
The Luohe River boasts a profound historical heritage. Due to long-term impacts of human activities along its banks, significant variations in soil environmental conditions may exist across different land use types within the region. This study focus...
Soil microorganisms play essential roles in maintaining the function and stability of forest ecosystems. In this study, conducted in the Jianfengling Nature Reserve in Hainan, we performed Illumina high-throughput sequencing, in combination with prin...
Membrane type 1 matrix metalloproteinase (MT1-MMP) has been shown to be crucial for tumor angiogenesis, invasion, and metastasis, and thus MT1-MMP is a high priority target for potential cancer therapies. To properly evaluate MT1-MMP inhibitors, a sc...
Soil microorganisms play a vital role in the biogeochemical cycle, whereas land use change is one of the primary factors that affects the biodiversity and functionality of terrestrial ecosystems. The composition and diversity of bacterial communities...
We explored the characteristics of soil bacterial communities and their ecological functions under different types of vegetation reclamation in open-pit mines on the Loess Plateau, which is the guiding significance for the selection of vegetation and...
Japanese larch (Larix kaempferi), a non-native tree species, has been widely planted in the Qinling Mountains since the last century, but it does not meet the habitat needs of giant pandas (Ailuropoda melanoleuca), mainly because of food, further cau...
Many rapid methods have been developed for screening foods for the presence of pathogenic microorganisms. Rapid methods that have the additional ability to identify microorganisms via multiplexed immunological recognition have the potential for class...
Neutrophils might play an important role in the pathogenesis of autoimmune diseases, including type 1 diabetes (T1D), by contributing to immune dysregulation via a highly inflammatory program called neutrophil extracellular trap (NET) formation or NE...
The effects of 44 types of elements on the stabilities of I1-constitute multi-type long-period stacking-ordered (LPSO) structures in Mg alloys, such as 4H, 6H, 8H, 9R, 12H, 15R, and 16H phases, are systematically investigated by first-principle high-...
Vaccination is highly effective in preventing human papillomavirus (HPV) infection, but traditional pseudovirion-based neutralization assays (PBNA) are technically demanding, labor-intensive, and costly, limiting their use in multivalent vaccine stud...
Recently an increasing number of new adenovirus types associated with type-dependent pathogenicity have been identified. However, identification of these clinical isolates represents the very first step to characterize novel pathogens. For deeper ana...
Molecular typing techniques are utilized to determine genetic similarities between bacterial isolates. However, the use of environmental DNA profiling to assess epidemiologic links between patients and their environment has not been fully explored. T...
The diagnosis of inherited metabolic disorders is a long and tedious process. The matching of clinical data with a genomic variant in a specific metabolic pathway is an essential step, but the link between a genome and the clinical data is normally d...
This study sought to clarify the composition of soil fungal and bacterial communities along an elevation gradient in an arid montane ecosystem as well as the influence of environmental factors (soil properties, climate, topography, and plant diversit...
Plants and their associated soil microorganisms interact with each other and form complex relationships. The effects of slash-and-burn agriculture and logging on aboveground plants and belowground microorganisms have been extensively studied, but res...
Glioma is the most common type of primary CNS tumor, composed of cells that resemble normal glial cells. Recent genetic studies have provided insight into the inter-tumoral heterogeneity of gliomas, resulting in the updated 2021 WHO classification of...
The most frequently observed congenital inner ear malformation is enlarged vestibular aqueduct (EVA). It is often accompanied with incomplete partition type 2 (IP2) of the cochlea and a dilated vestibule, which together constitute Mondini malformatio...
Synechococcus is a dominant genus of the coastal phytoplankton with an effective contribution to primary productivity. Here, the phylogenetic and phenogenetic composition of Synechococcus in the coastal Yellow Sea was addressed by sequencing marker g...
30 May 2026
The increasing complexity of artificial intelligence systems and algorithms can negatively affect individual attitudes and prompt them to adopt coping behaviors. Based on the technology threat avoidance theory, this study explores the mechanisms thro...
Soil bacterial communities play a key role in nutrient cycling and ecosystem functioning. This study aims to reveal how green space type impacts soil quality and the bacterial community, which finally contributes to suggesting strategies for managing...
In this work, we studied 217 Mexican subjects divided into six groups with different stages of glucose intolerance: 76 Controls (CO), 54 prediabetes (PRE), 14 T2D no medication (T2D−No−M), 14 T2D with Metformin (T2D−M), 22 T2D with...
We collated publicly available single-cell expression profiles of circulating tumor cells (CTCs) and showed that CTCs across cancers lie on a near-perfect continuum of epithelial to mesenchymal (EMT) transition. Integrative analysis of CTC transcript...
Soil microorganisms play an essential role in vegetation succession, nutrient cycling, and ecosystem restoration. This study investigates the responses of soil microbial communities to ecological transitions from forest to wetland in the Lesser Khing...
Shiga toxins 1 and 2 (Stx1 and Stx2) from Shiga toxin-producing E. coli (STEC) bacteria were simultaneously detected with a newly developed, high-throughput antibody microarray platform. The proteinaceous toxins were immobilized and sandwiched betwee...
High-throughput microarray technologies have long been a source of data for a wide range of biomedical investigations. Over the decades, variants have been developed and sophistication of measurements has improved, with generated data providing both...
We consider a Sensor-Aided Cognitive Radio Network (SACRN) in which sensors capable of harvesting energy are distributed throughout the network to support secondary transmitters for sensing licensed channels in order to improve both energy and spectr...
High-throughput screening is a potent technique to accelerate the discovery and development of new materials. By performing massive synthesis and characterization processes in parallel, it can rapidly discover materials with desired components, struc...
Intensive lane-changing (LC) events are one of the great causes that make freeway weaving areas become bottlenecks. This study proposes an approach using vehicle trajectory data to investigate the spatiotemporal distributions of the number of LC even...
Due to the global rise of type 2 diabetes mellitus (T2DM) in combination with insulin resistance, novel compounds to efficiently treat this pandemic disease are needed. Screening for compounds that induce the translocation of glucose transporter 4 (G...
The main design goals of the multipath transmission control protocol (MPTCP) are to improve the throughput and share a common bottleneck link fairly with a single-path transmission control protocol (TCP). The existing MPTCP congestion control algorit...
In wireless networks, MAC scheduling methods can be divided into two types according to the implementation model: centralized and distributed scheduling. By reasonably designing MAC scheduling policies, both centralized and distributed schedulers can...
We consider a wireless network comprising two types of nodes: Type I node and Type II node. The Type I node has unlimited energy supply and the Type II node is powered by radio frequency (RF) energy harvesting where the RF transmissions by the Type I...
The development of high-throughput sequencing (next-generation sequencing technology (NGS)) and the continuous increase in experimental throughput require the upstream sample processing steps of NGS to be as simple as possible to improve the efficien...
More than 160 types of post-transcriptional RNA modifications have been identified, revealing considerable diversity in their types, abundances, distributions, and functional roles across different RNAs, cells, and tissues in humans. Recent advances...
High-throughput screenings are widely accepted for pharmaceutical developments for new substances and the development of new drugs with required characteristics by evolutionary studies. Current research projects transfer this principle of high-throug...
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