Human Leukocyte Antigen (HLA)—Antigen Interactions in Vaccine Development

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 12 November 2024 | Viewed by 102

Special Issue Editor

E-Mail Website
Guest Editor
Department of Neuroscience, Brain Sciences Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Interests: human leukocyte antigen; vaccines against pathogens; vaccines against SARS-CoV-2; vaccines against cancer; human herpes and other viruses; cancer neoantigens
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Vaccines are widely used to prevent illness by pathogens and, more recently, kill cancer cells. In both cases, vaccines contain the antigens of pathogens (e.g., viral proteins) or antigens of cancers (e.g., cancer neoantigens), and are administered to healthy people (for prevention of infection) or patients (for cancer therapy). The success of vaccines in prevention or therapy depends critically on the ability of the host to make antibodies against the antigen(s) of the vaccines: if antibodies cannot be made, the vaccine will not be effective. The successful mounting of antibodies against specific antigens critically depends on the host's HLA Class II genetic makeup. The focus of this Special Issue lies in the interactions of vaccine antigen(s) and HLA Class II molecules binding together to initiate antibody production. This matter is of major scientific, medical and public health importance. For this Special Issue, original research articles and reviews in biological, biophysical, evolutionary, computational, clinical, epidemiological and theoretical research areas are welcome, that may include (but not limited to) the following as representative examples:

  • Biological: Evaluation of the role of HLA in antibody production for specific vaccine targets (pathogens, cancer neoantigens).
  • Biophysical: Modeling of biophysical aspects of antigen–HLA molecule binding.
  • Evolutionary: Investigation of the parallel evolution of pathogens and HLA.
  • Computational: In silico estimation of antigen–HLA binding aaffinities.
  • Clinical: Investigation of the dependence of cancer vaccine therapy on the patients’ HLA makeup.
  • Epidemiological: Investigation of HLA makeup as a factor in the clinical efficacy of vaccines within populations.
  • Theoretical: Exploring aspects of antigen–HLA interactions for future optimal vaccine design.   

I look forward to receiving your contributions.

Prof. Dr. Apostolos P. Georgopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • HLA
  • vaccine
  • antigen
  • antibody
  • cancer
  • binding affinity
  • biophysical modeling
  • lymphocytes

Published Papers

This special issue is now open for submission.
Back to TopTop