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43,959 Results Found

  • Article
  • Open Access
2 Citations
2,387 Views
19 Pages

6 July 2023

One of the key goals of geodesy is to study the fine structure of the Earth’s gravity field and construct a high-resolution gravity field model (GFM). Aiming at the current insufficient resolution problem of the EIGEN_6C4 model, the refined ult...

  • Article
  • Open Access
8 Citations
3,041 Views
16 Pages

Finite Element Modeling of Brittle and Ductile Modes in Cutting of 3C-SiC

  • Masud Alam,
  • Liang Zhao,
  • Napat Vajragupta,
  • Junjie Zhang and
  • Alexander Hartmaier

24 October 2021

Machining of brittle ceramics is a challenging task because the requirements on the cutting tools are extremely high and the quality of the machined surface strongly depends on the chosen process parameters. Typically, the efficiency of a machining p...

  • Article
  • Open Access
1 Citations
1,524 Views
11 Pages

3 January 2025

Background/Objectives: Injuries involving the Atlas (C1) and Axis (C2) vertebrae of the cervical spine present significant clinical challenges due to their complex anatomy and potential for severe neurological impairment. Traditional imaging methods...

  • Article
  • Open Access
12 Citations
7,966 Views
22 Pages

The antiplatelet agent clopidogrel is listed by the FDA as a strong clinical index inhibitor of cytochrome P450 (CYP) 2C8 and weak clinical inhibitor of CYP2B6. Moreover, clopidogrel is a substrate of—among others—CYP2C19 and CYP3A4. This...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,903 Views
16 Pages

A Novel Fractional-Order RothC Model

  • Vsevolod Bohaienko,
  • Fasma Diele,
  • Carmela Marangi,
  • Cristiano Tamborrino,
  • Sebastian Aleksandrowicz and
  • Edyta Woźniak

31 March 2023

A new fractional q-order variation of the RothC model for the dynamics of soil organic carbon is introduced. A computational method based on the discretization of the analytic solution along with the finite-difference technique are suggested and the...

  • Article
  • Open Access
348 Views
29 Pages

30 November 2025

The Converter/Distributor (C/D) model, as proposed by Fujimura is theoretically grounded on articulatory observations of X-ray microbeam (XRMB) data that show that utterance syllable prominence patterns “dictate” the size, timing and phra...

  • Article
  • Open Access
33 Citations
8,995 Views
18 Pages

Effective Suckling C57BL/6, Kunming, and BALB/c Mouse Models with Remarkable Neurological Manifestation for Zika Virus Infection

  • Jianhai Yu,
  • Xuling Liu,
  • Changwen Ke,
  • Qinghua Wu,
  • Weizhi Lu,
  • Zhiran Qin,
  • Xiaoen He,
  • Yujing Liu,
  • Jieli Deng and
  • Suiqi Xu
  • + 8 authors

29 June 2017

Since 2015, 84 countries and territories reported evidence of vector-borne Zika Virus (ZIKV) transmission. The World Health Organization (WHO) declared that ZIKV and associated consequences especially the neurological autoimmune disorder Guillain–Bar...

  • Article
  • Open Access
38 Citations
10,910 Views
13 Pages

Cytochrome C Biosensor—A Model for Gas Sensing

  • Michael Hulko,
  • Ingeborg Hospach,
  • Nadejda Krasteva and
  • Gabriele Nelles

1 June 2011

This work is about gas biosensing with a cytochrome c biosensor. Emphasis is put on the analysis of the sensing process and a mathematical model to make predictions about the biosensor response. Reliable predictions about biosensor responses can prov...

  • Article
  • Open Access
78 Citations
5,228 Views
15 Pages

Evaluation of Empirical Atmospheric Models Using Swarm-C Satellite Data

  • Lirong Yin,
  • Lei Wang,
  • Wenfeng Zheng,
  • Lijun Ge,
  • Jiawei Tian,
  • Yan Liu,
  • Bo Yang and
  • Shan Liu

9 February 2022

Swarm-C satellite, a new instrument for atmospheric study, has been the focus of many studies to evaluate its usage and accuracy. This paper takes the Swarm-C satellite as a research object to verify the Swarm-C accelerometer’s inversion result...

  • Review
  • Open Access
36 Citations
7,184 Views
21 Pages

Animal Models Used in Hepatitis C Virus Research

  • Keith A. Berggren,
  • Saori Suzuki and
  • Alexander Ploss

The narrow range of species permissive to infection by hepatitis C virus (HCV) presents a unique challenge to the development of useful animal models for studying HCV, as well as host immune responses and development of chronic infection and disease....

  • Article
  • Open Access
4 Citations
3,844 Views
25 Pages

This paper proposes a flow-path-network-based (FPN-based) algorithm, constructed from a square-grid digital elevation model (DEM) to improve the simulation of the flow path curvature (C). First, the flow-path network model was utilized to obtain an F...

  • Feature Paper
  • Article
  • Open Access
3 Citations
4,006 Views
21 Pages

26 July 2021

The development of selective and robust heterogeneous oxidation catalysts is an enabling technology for conversion of biomass-derived platform chemicals. Vanadium active sites were incorporated into the structure of mesoporous silica via an ultra-fas...

  • Article
  • Open Access
2 Citations
2,915 Views
18 Pages

Enhancing Single-Cell and Bulk Hi-C Data Using a Generative Transformer Model

  • Ruoying Gao,
  • Thomas N. Ferraro,
  • Liang Chen,
  • Shaoqiang Zhang and
  • Yong Chen

12 March 2025

The 3D organization of chromatin in the nucleus plays a critical role in regulating gene expression and maintaining cellular functions in eukaryotic cells. High-throughput chromosome conformation capture (Hi-C) and its derivative technologies have be...

  • Article
  • Open Access
3 Citations
2,461 Views
6 Pages

22 April 2022

In this paper, a model for the forward voltage drop in a 4H-SiC trench IGBT is developed. The analytical model is based on the 4H-SiC trench MOSFET voltage model and the hole-carrier concentration profile in the N-drift region for a conventional 4H-S...

  • Article
  • Open Access
8 Citations
7,814 Views
20 Pages

1 December 2017

Currently, the auxiliary converter in the auxiliary power supply system of a modern tram adopts Si IGBT as its switching device and with the 1700 V/225 A SiC MOSFET module commercially available from Cree, an auxiliary converter using all SiC devices...

  • Article
  • Open Access
6 Citations
2,290 Views
18 Pages

13 September 2023

Isothermal deformation experiments of the Hastelloy C276 alloy were executed using the Gleeble-3500 hot simulator at a temperature range of 1000–1150 °C and a strain rate range of 0.01–10 s−1. Microstructural evolution mechanism...

  • Article
  • Open Access
5 Citations
7,575 Views
17 Pages

Constraining Genome-Scale Models to Represent the Bow Tie Structure of Metabolism for 13C Metabolic Flux Analysis

  • Tyler W. H. Backman,
  • David Ando,
  • Jahnavi Singh,
  • Jay D. Keasling and
  • Héctor García Martín

Determination of internal metabolic fluxes is crucial for fundamental and applied biology because they map how carbon and electrons flow through metabolism to enable cell function. 13 C Metabolic Flux Analysis ( 13 C MFA) and Two-Scale...

  • Article
  • Open Access
4 Citations
1,719 Views
13 Pages

29 August 2022

Obtaining surface albedo data with high spatial and temporal resolution is essential for measuring the factors, effects, and change mechanisms of regional land-atmosphere interactions in deserts. In order to obtain surface albedo data with higher acc...

  • Article
  • Open Access
2,482 Views
17 Pages

Multiparametric Characterization of the DSL-6A/C1 Pancreatic Cancer Model in Rats

  • Patrick Schmidt,
  • Johannes Lindemeyer,
  • Pranali Raut,
  • Markus Schütz,
  • Sven Saniternik,
  • Jannika Jönsson,
  • Heike Endepols,
  • Thomas Fischer,
  • Alexander Quaas and
  • Hans Anton Schlößer
  • + 2 authors

17 April 2024

The DSL-6A/C1 murine pancreatic ductal adenocarcinoma (PDAC) tumor model was established in Lewis rats and characterized through a comprehensive multiparametric analysis to compare it to other preclinical tumor models and explore potential diagnostic...

  • Article
  • Open Access
1 Citations
2,652 Views
20 Pages

3D Modelling with C2 Continuous PDE Surface Patches

  • Haibin Fu,
  • Shaojun Bian,
  • Ouwen Li,
  • Jon Macey,
  • Andres Iglesias,
  • Ehtzaz Chaudhry,
  • Lihua You and
  • Jian Jun Zhang

20 January 2022

In this paper, we present a new modelling method to create 3D models. First, characteristic cross section curves are generated and approximated by generalized elliptic curves. Then, a vector-valued sixth-order partial differential equation is propose...

  • Article
  • Open Access
1 Citations
1,344 Views
19 Pages

2 December 2024

Accurate modeling of the switching transients of SiC MOSFETs is essential for overvoltage evaluation, EMI prediction, and other critical applications. Due to the fast switching speed, the switching transients of SiC MOSFETs are highly sensitive to pa...

  • Article
  • Open Access
2,788 Views
22 Pages

Precise Modeling of Thermal and Strain Rate Effect on the Hardening Behavior of SiC/Al Composite

  • Yanju Wang,
  • Pengfei Wu,
  • Xiaolei He,
  • Wei Zhao,
  • Xiang Lan and
  • Yanshan Lou

8 March 2022

Temperature and strain rate have significant effects on the mechanical behavior of SiC/Al 2009 composites. This research aimed to precisely model the thermal and strain rate effect on the strain hardening behavior of SiC/Al composite using the artifi...

  • Article
  • Open Access
18 Citations
6,677 Views
16 Pages

Virtual reality (VR) is an emerging technology with a variety of potential benefits for vocational training. Therefore, this paper presents a VR training based on the highly validated 4C/ID model to train vocational competencies in the field of vehic...

  • Article
  • Open Access
1,300 Views
23 Pages

Background/Objectives: Hypertension is a pathological condition characterized by elevated systolic and/or diastolic blood pressure. A range of pharmacotherapeutic agents are available to treat this condition and prevent complications, including the a...

  • Review
  • Open Access
10 Citations
14,384 Views
32 Pages

30 April 2022

According to the IPCC, a global carbon budget of 400 GtCO2 is required to limit the temperature rise to 1.5 °C with a 67% likelihood by 2050. The finance industry is increasingly committed to ambitious climate targets. In this article, we describ...

  • Article
  • Open Access
1,507 Views
15 Pages

18 January 2024

A new approach is presented in this paper for the dynamic modeling of the chemical and isotopic evolution of C1–3 during the hydrocarbon generation process. Based on systematic data obtained from published papers for the pyrolysis of various hy...

  • Article
  • Open Access
19 Citations
4,100 Views
14 Pages

The Anti-Tumorigenic Activity of Sema3C in the Chick Embryo Chorioallantoic Membrane Model

  • Indrė Valiulytė,
  • Rūta Curkūnavičiūtė,
  • Laura Ribokaitė,
  • Arunas Kazlauskas,
  • Monika Vaitkevičiūtė,
  • Kęstutis Skauminas and
  • Angelija Valančiūtė

12 November 2019

Sema3C protein, a member of the class 3 family of secreted semaphorins, play an important role in tumor development by regulating cell proliferation, migration, invasion, and angiogenesis processes. Depending on the type and malignancy grade of the t...

  • Article
  • Open Access
11 Citations
6,189 Views
14 Pages

26 April 2024

Due to the rapid development of high-speed trains, the service safety of vehicle body materials and structures has become a focal point in transport and impact engineering. Numerical simulations on the collision resistance of vehicle materials and st...

  • Article
  • Open Access
1,169 Views
15 Pages

12 September 2024

Recognizing the lightweight nature and superior tribological properties of Al-based metal matrix composites, this study introduces a novel analytical model based on polynomial approximations, offering new insights into the mechanisms of dry friction...

  • Article
  • Open Access
7 Citations
3,129 Views
15 Pages

Modeling of Charge-to-Breakdown with an Electron Trapping Model for Analysis of Thermal Gate Oxide Failure Mechanism in SiC Power MOSFETs

  • Jiashu Qian,
  • Limeng Shi,
  • Michael Jin,
  • Monikuntala Bhattacharya,
  • Atsushi Shimbori,
  • Hengyu Yu,
  • Shiva Houshmand,
  • Marvin H. White and
  • Anant K. Agarwal

22 March 2024

The failure mechanism of thermal gate oxide in silicon carbide (SiC) power metal oxide semiconductor field effect transistors (MOSFETs), whether it is field-driven breakdown or charge-driven breakdown, has always been a controversial topic. Previous...

  • Article
  • Open Access
4 Citations
1,700 Views
25 Pages

Distributed Model Predictive Control Based on Bus Voltage Derivative and SoC Dynamic Model for Shipboard DC Microgrids

  • Changyu Ban,
  • Sunhua Huang,
  • Linyun Xiong,
  • Yang Zhou,
  • Qingde Wang,
  • Ruikai Song,
  • Luwei Wang and
  • Fei Li

State-of-charge (SoC) consistency and bus voltage regulation are two major control objectives of shipboard DC microgrids. To achieve these objectives, this paper presents a novel distributed model predictive control (DMPC) strategy with multiple cost...

  • Article
  • Open Access
7 Citations
2,405 Views
13 Pages

19 June 2022

Mathematical models, some of which incorporate both intracellular and extracellular hepatitis C viral kinetics, have been advanced in recent years for studying HCV–host dynamics, antivirals mode of action, and their efficacy. The standard ordin...

  • Article
  • Open Access
2 Citations
2,373 Views
19 Pages

19 July 2025

Climate change poses one of the greatest challenges of our time, with greenhouse gas (GHG) emissions significantly contributing to global warming. The agriculture, forestry, and land-use (AFOLU) sectors not only emit GHGs but also offer the potential...

  • Article
  • Open Access
10 Citations
3,538 Views
30 Pages

28 January 2021

SiC MOSFETs have an excellent characteristic of high switching speed, which can improve the efficiency and power density of converters significantly. However, the fast switching processes of SiC MOSFETs cause serious crosstalk problems in bridge-arm...

  • Article
  • Open Access
1,535 Views
17 Pages

Monitoring of Vitamin C Plasma Levels in a Reversible Model of Malabsorption Generated in Mice by Ebulin-f

  • Daniel Arranz-Paraiso,
  • M. Angeles Rojo,
  • Cristina Martin-Sabroso,
  • Manuel Cordoba-Diaz,
  • Tomás Girbés,
  • Manuel Garrosa and
  • Damian Cordoba-Diaz

30 June 2025

The development of reversible animal models for the study of intestinal pathologies is essential to reduce the number of animals used in research and to better understand disease mechanisms. In this study, we present a reversible model of intestinal...

  • Article
  • Open Access
23 Citations
16,822 Views
18 Pages

Streptozotocin-Induced Diabetes in a Mouse Model (BALB/c) Is Not an Effective Model for Research on Transplantation Procedures in the Treatment of Type 1 Diabetes

  • Michal Wszola,
  • Marta Klak,
  • Anna Kosowska,
  • Grzegorz Tymicki,
  • Andrzej Berman,
  • Anna Adamiok-Ostrowska,
  • Joanna Olkowska-Truchanowicz,
  • Izabela Uhrynowska-Tyszkiewicz and
  • Artur Kaminski

29 November 2021

Type 1 diabetes (T1D) is characterized by the destruction of over 90% of the β-cells. C-peptide is a parameter for evaluating T1D. Streptozotocin (STZ) is a standard method of inducing diabetes in animals. Eight protocols describe the administra...

  • Article
  • Open Access
7 Citations
3,265 Views
28 Pages

Accurate fault simulation and failure prediction have long been challenges for SiC MOSFETs users. This paper presents a behavior model of Silicon Carbide (SiC) double-implanted MOSFET (DMOSFET), considering thermal-runaway failures in short-circuit a...

  • Article
  • Open Access
15 Citations
8,087 Views
9 Pages

15 November 2013

Fresh jujube (Ziziphus jujube) is rich in vitamin C, which is an important quality index and generally decreases with storage time. The aim of this study was to build kinetic models for determining the vitamin C content, thus predicting the quality c...

  • Article
  • Open Access
23 Citations
7,569 Views
13 Pages

Study on the Mechanism of Intestinal Absorption of Epimedins A, B and C in the Caco-2 Cell Model

  • Yan Chen,
  • Ying Wang,
  • Jing Zhou,
  • Xia Gao,
  • Ding Qu and
  • Congyan Liu

7 January 2014

Epimedium spp. is commonly used in Traditional Chinese Medicine. Epimedins A, B, and C are three major bioactive flavonoids found in Epimedium spp. that share similar chemical structures. In this study, the intestinal absorption mechanism of these th...

  • Article
  • Open Access
2 Citations
2,648 Views
9 Pages

25 September 2022

4H-silicon carbide metal-oxide-semiconductor field-effect transistors (4H-SiC MOSFETs) show 1/f low-frequency noise behavior. In this paper, this can be explained by the combination of the mobility fluctuation (Δμ) and the carrier number flu...

  • Article
  • Open Access
1 Citations
2,015 Views
21 Pages

Enhanced Resolution of Neutron Autoradiography with UV-C Sensitization to Study Boron Microdistribution in Animal Models

  • Agustina Mariana Portu,
  • María Sol Espain,
  • Silvia Inés Thorp,
  • Verónica Andrea Trivillin,
  • Paula Curotto,
  • Andrea Monti Hughes,
  • Emiliano César Cayetano Pozzi,
  • Marcela Alejandra Garabalino,
  • Mónica Alejandra Palmieri and
  • Pablo Nicolás Granell
  • + 3 authors

18 July 2023

The assessment of boron microdistribution is essential to evaluate the suitability of boron neutron capture therapy (BNCT) in different biological models. In our laboratory, we have reported a methodology to produce cell imprints on polycarbonate thr...

  • Article
  • Open Access
3 Citations
3,114 Views
19 Pages

29 November 2019

Establishing an accurate inverse model is a key problem in the design of adaptive inverse controllers. Most real objects have nonlinear characteristics, so mathematical expression of an inverse model cannot be obtained in most situation. A Takagi&nda...

  • Article
  • Open Access
10 Citations
6,567 Views
36 Pages

3D Spatially Resolved Models of the Intracellular Dynamics of the Hepatitis C Genome Replication Cycle

  • Markus M. Knodel,
  • Sebastian Reiter,
  • Paul Targett-Adams,
  • Alfio Grillo,
  • Eva Herrmann and
  • Gabriel Wittum

30 September 2017

Mathematical models of virus dynamics have not previously acknowledged spatial resolution at the intracellular level despite substantial arguments that favor the consideration of intracellular spatial dependence. The replication of the hepatitis C vi...

  • Article
  • Open Access
1 Citations
2,605 Views
14 Pages

Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research

  • Yixiao Bin,
  • Sanhua Wei,
  • Ruo Chen,
  • Haowei Zhang,
  • Jing Ren,
  • Peijuan Liu,
  • Zhiqian Xin,
  • Tianjiao Zhang,
  • Haijiao Yang and
  • Ke Wang
  • + 4 authors

2 February 2024

Severe combined immunodeficient (SCID) mice serve as a critical model for human xenotransplantation studies, yet they often suffer from low engraftment rates and susceptibility to graft-versus-host disease (GVHD). Moreover, certain SCID strains demon...

  • Feature Paper
  • Article
  • Open Access
186 Citations
13,943 Views
13 Pages

Calibration of the Water Cloud Model at C-Band for Winter Crop Fields and Grasslands

  • Nicolas Baghdadi,
  • Mohammad El Hajj,
  • Mehrez Zribi and
  • Safa Bousbih

20 September 2017

In a perspective to develop an inversion approach for estimating surface soil moisture of crop fields from Sentinel-1/2 data (radar and optical sensors), the Water Cloud Model (WCM) was calibrated from C-band Synthetic Aperture Radar (SAR) data and N...

  • Article
  • Open Access
21 Citations
4,765 Views
17 Pages

An Improved Genome-Scale Metabolic Model of Arthrospira platensis C1 (iAK888) and Its Application in Glycogen Overproduction

  • Amornpan Klanchui,
  • Sudarat Dulsawat,
  • Kullapat Chaloemngam,
  • Supapon Cheevadhanarak,
  • Peerada Prommeenate and
  • Asawin Meechai

26 November 2018

Glycogen-enriched biomass of Arthrospira platensis has increasingly gained attention as a source for bioethanol production. To study the metabolic capabilities of glycogen production in A. platensis C1, a genome-scale metabolic model (GEM) could be a...

  • Article
  • Open Access
3 Citations
5,488 Views
25 Pages

Carbamazepine (CBZ) is commonly prescribed for epilepsy and frequently used in polypharmacy. However, concerns arise regarding its ability to induce the metabolism of other drugs, including itself, potentially leading to the undertreatment of co-admi...

  • Article
  • Open Access
4 Citations
2,712 Views
12 Pages

Anti-Metastatic Activity of Tagitinin C from Tithonia diversifolia in a Xenograft Mouse Model of Hepatocellular Carcinoma

  • Chuan-Yi Lin,
  • May-Hua Liao,
  • Chi-Yu Yang,
  • Chao-Kai Chang,
  • Shih-Mei Hsu,
  • Chi-Long Juang and
  • Hsiao-Chuan Wen

1 December 2022

Sesquiterpenoid tagitinin C, present in Tithonia diversifolia leaves, has been known to have anti-hepatoma properties. Therefore, we investigated the anti-metastatic potential of tagitinin C in xenograft models of hepatocellular carcinoma (HCC). We i...

  • Article
  • Open Access
11 Citations
3,698 Views
11 Pages

Modeling Mechanical Properties of 25Cr-20Ni-0.4C Steels over a Wide Range of Temperatures by Neural Networks

  • P. L. Narayana,
  • Jae H. Kim,
  • A. K. Maurya,
  • Chan Hee Park,
  • Jae-Keun Hong,
  • Jong-Taek Yeom and
  • N. S. Reddy

16 February 2020

From the point of view of designing materials, it is important to study the complex correlational research that involves measuring several variables and assessing the relation among them. Hence, the notion of machine-oriented data modeling is explore...

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