Studies have revealed the dependence of glioma cells on iron, making them sensitive to ferroptosis. Ferroptosis can be triggered by inhibition of the xc- system, resulting in redox imbalance and membrane lipid peroxidation. The xc- system is composed...
A glutamate/NMDA receptor (NMDA-R) antagonist, amantadine (AMA) exhibits a broad spectrum of clinically important properties, including antiviral, antiparkinsonian, neuroprotective, neuro-reparative and cognitive-enhancing effects. However, both clin...
Background: Danshen–Gegen is a classic herb pair in traditional Chinese medicine, which has been used to treat cardiovascular and cerebrovascular diseases. Ischemic stroke (IS) is a prevalent cerebrovascular condition; ferroptosis is one of the...
Amyloid-β (Aβ) deposition, a hallmark of Alzheimer’s disease, is known to induce free radical production and oxidative stress, leading to neuronal damage. During oxidative stress, several cell types (including astrocytes) can activate the nuclear fac...
System xc− is upregulated in cancer cells and can be imaged using novel radiotracers, most commonly with (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid (18F-FSPG). The aim of this review was to summarise the use of 18F-FSPG in humans, explore the...
Oxidative damage has been identified as a major causative factor in degenerative diseases of the retina; retinal pigment epithelial (RPE) cells are at high risk. Hence, identifying novel strategies for increasing the antioxidant capacity of RPE cells...
Background: (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) positron emission tomography/computed tomography (PET/CT) provides a readout of system xc− transport activity and has been used for cancer detection in clinical studies of dif...
Sickle cell disease (SCD) is an inherited hemoglobin disorder that is widespread across the globe. It is characterized by a very complex pathogenesis, but at the basis of the disease is the mutation of the HBB gene, which determines the production of...
Ferroptosis is a form of cell death that is distinguished from other types of death for its peculiar characteristics of death regulated by iron accumulation, increase in ROS, and lipid peroxidation. In the past few years, experimental evidence has co...
Neurodegenerative diseases are a group of diseases that share common features, such as the generation of misfolded protein deposits and increased oxidative stress. Among them, amyotrophic lateral sclerosis (ALS), whose pathogenesis is still not entir...
Background/Objectives: Colorectal cancer (CRC) is characterized by a high rate of both incidence and mortality, and its treatment outcomes are often affected by recurrence and drug resistance. Ferroptosis, an iron-dependent programmed cell death mech...
There is a growing body of evidence that metabolic reprogramming contributes to the acquisition and maintenance of robustness associated with malignancy. The fine regulation of expression levels of amino acid and monocarboxylate transporters enables...
Ovarian cancer is the main cause of death from gynecological cancer, with its poor prognosis mainly related to late diagnosis and chemoresistance (acquired or intrinsic) to conventional alkylating and reactive oxygen species (ROS)-generating drugs. W...
Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential as a redox metal in several physiological functions. The...
Male reproductive health is critically worsening around the world. It has been reported that the mycotoxin ZEA causes reproductive toxicity to domestic animals and affects spermatogenesis, thereby inhibiting male reproductive function. Ferroptosis is...
14 September 2022
Purpose: To examine the contributions of time in different terrains and sub-technique distribution to overall time-trial performance, as well as the relationships of laboratory and field-based performance determinants in cross-country skiers. Methods...
This article is positioned into a cross-section of machine learning, cybersecurity, and nature-inspired domains. This article’s main objective is to use eXtended Classifier System (XCS), a known adaptive Reinforcement Learning (RL) algorithm, a...
Glutamate, a crucial excitatory neurotransmitter, plays a major role in the modulation of schizophrenia’s pathogenesis. New drug developments for schizophrenia have been prompted by the hypoglutamatergic hypothesis of schizophrenia. The cystine/gluta...
Cross channel scripting (XCS) is a common web application vulnerability, which is a variant of a cross-site scripting (XSS) attack. An XCS attack vector can be injected through network protocol and smart devices that have web interfaces such as route...
System xc−, the cystine/glutamate exchanger, is a membrane transporter that plays a critical role in the antioxidant response of cells. Recent work has shown that System xc− localizes to the plasma membrane during oxidative stress, allowi...
In this work, nonadiabatic exchange-correlation (XC) potentials for time-dependent density-functional theory (TDDFT) for strongly correlated materials are derived in the limits of strong and weak correlations. After summarizing some essentials of the...
In the absence of user experience evaluation tools for industrial human–machine interfaces (HMI), a specific tool called eXperience Capturer (XC) has been created. It is a multi-method user-centred tool that evaluates the pragmatic and experien...
As multimedia traffic has been increasing and is expected to grow more sharply, various technologies using caches have been attracting lots of attention. As one breakthrough technology to deal with the explosively growing traffic, exclusive OR (XOR)-...
Halogen bonds (XBs) between metal anions and halides have seldom been reported because metal anions are reactive for XB donors. The pyramidal-shaped Mn(CO)5− anion is a candidate metallic XB acceptor with a ligand-protected metal core that main...
This work reports the quasi-atomic orbital analysis of the XC(NO2)3 (X=F, Cl, Br, and I) compounds and shows that the interactions between the C-N σ bonds and the lone electron pairs on the halogen atom and oxygen atoms of the nitro groups may...
The aim of the current study was to evaluate the possibility of application of bioelectrical impedance analysis (BIA) in order to estimate pork quality. The BIA measurements were tested on 18 living animals for the prediction of the meat quality. The...
Ferroptosis is a type of iron-dependent cell death pertaining to an excess of lipid peroxidation. It has been suggested that sorafenib—an anti-angiogenic medication for hepatocellular carcinoma (HCC)—induces ferroptosis, but the underlyin...
Microencapsulations of Lactobacillus acidophilus in xanthan-chitosan (XC) and xanthan-chitosan-xanthan (XCX) polyelectrolyte complex (PEC) gels were prepared in this study. The process of encapsulation was optimized with the aid of response surface m...
This work discusses the development of analytical expressions for the configurational entropy of different states of matter using a method based on the identification of the energy-independent complexes (clustering of atoms) in the system and the cal...
This study developed a nitrogen management framework that simultaneously addresses photosynthetic limitations and water scarcity challenges, providing a scalable solution for sustainable wheat production in arid farming systems. Focusing on Xinjiang&...
The aims of the study were to assess the robustness and non-reactiveness of wearable near-infrared spectroscopy (NIRS) technology to monitor exercise intensity during a real race scenario, and to compare oxygenation between muscle groups important fo...
The Trans-Activator of Transcription (Tat) of Human Immunodeficiency Virus (HIV-1) is involved in virus replication and infection and can promote oxidative stress in human astroglial cells. In response, host cells activate transcription of antioxidan...
Coastal lagoons are crucial transitional zones connecting land and sea, and their ecological connectivity with adjacent open waters directly sustains regional biodiversity and ecosystem functions. However, how lagoon fish communities connect on a diu...
Our aims were to evaluate the feasibility of a framework based on micro-sensor technology for in-field analyses of performance and sub-technique selection in Para cross-country (XC) skiing by using it to compare these parameters between elite standin...
We present some details of our recently-proposed Time-Dependent Density-Functional Theory (TDDFT) for strongly-correlated materials in which the exchange-correlation (XC) kernel is derived from the charge susceptibility obtained using Dynamical Mean-...
Confining protons into an enclosed carbon cage is expected to give rise to unique electronic properties for both the inner proton and the outer cage. In this work, we systematically investigated the geometric and electronic structures of cationic X+@...
Objective: This work presents an implementation of a stable algorithm that recovers sources located at the boundary separating two homogeneous media in field-programmable gate arrays. Two loop unrolling architectures were developed and analyzed for t...
Ultra-high-temperature ceramics (UHTCs) in the Ta–Hf–C ternary system are of significant interest for extreme aerospace and energy applications due to their melting points near 4000 °C. However, their synthesis typically requires extr...
Today, convolutional and deconvolutional neural network models are exceptionally popular thanks to the impressive accuracies they have been proven in several computer-vision applications. To speed up the overall tasks of these neural networks, purpos...
A comprehensive analysis of selected DFT exchange–correlation functionals is presented, focusing on their performance in treating gold nanoclusters and on their known reliability for the description of organic species, energy barriers and dispe...
Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of cell death and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by specific modulators (e.g., drug...
Finite-temperature density functional theory (DFT) has become of topical interest, partly due to the increasing ability to create novel states of warm-correlated matter (WCM).Warm-dense matter (WDM), ultra-fast matter (UFM), and high-energy density m...
Hyperspectral imaging is a technology which, by sensing hundreds of wavelengths per pixel, enables fine studies of the captured objects. This produces great amounts of data that require equally big storage, and compression with algorithms such as the...
Bone marrow (BM) is the most common site of neuroblastoma (NB) metastasis, and its involvement represents poor patient prognosis. In accordance with the “seed and soil” theory of tumor metastasis, BM provides a favorable environment for N...
Ferroptosis is caused by the iron-mediated accumulation of lipid peroxidation, which is distinct from apoptosis and necroptosis. Necrostatin-1 inhibits receptor-interacting serine/threonine-protein kinase 1 (RIPK1) to initiate necroptosis; it also in...
The present work numerically investigates the effect of a cavity implemented in a premixed methane/air micro-combustor on enhancing its thermal performances and thermodynamic efficiencies for micro-thermophotovoltaic applications. The 3D time-domain...
Background/Objectives: In the context of preclinical studies, we have hitherto showcased that a low-molecular-weight ruthenium(III) complex we named AziRu holds significant potential for further developments as an anticancer candidate drug. When appr...
Accurate short-term wind speed forecasting is essential for the sustainable operation and planning of coastal wind farms. This study develops an improved BP-PSO hybrid model that integrates particle-swarm optimization, time-ordered walk-forward valid...
Bicelles have been intensively studied for use as drug delivery carriers and in biological studies, but their preparation with low-cost materials and via a simple process would allow their use for other purposes as well. Herein, bicelles were prepare...
Cross-country skiing (XCS) embraces a broad variety of techniques applied like a gear system according to external conditions, slope topography, and skier-related factors. The continuous detection of applied skiing techniques and cycle characteristic...
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