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Article

Formulation of Bicelles Based on Lecithin-Nonionic Surfactant Mixtures

1
Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan
2
Australian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organisation (ANSTO), Lucas Heights, New South Wales 2234, Australia
3
Research and Development Division, KOSÉ Corporation, Tokyo 114-0005, Japan
*
Author to whom correspondence should be addressed.
Materials 2020, 13(14), 3066; https://doi.org/10.3390/ma13143066
Received: 29 May 2020 / Revised: 2 July 2020 / Accepted: 6 July 2020 / Published: 9 July 2020
(This article belongs to the Special Issue Structure, Dynamics, and Phase Equilibria of Colloidal Dispersions)
Bicelles have been intensively studied for use as drug delivery carriers and in biological studies, but their preparation with low-cost materials and via a simple process would allow their use for other purposes as well. Herein, bicelles were prepared through a semi-spontaneous method using a mixture of hydrogenated soybean lecithin (SL) and a nonionic surfactant, polyoxyethylene cholesteryl ether (ChEO10), and then we investigated the effect of composition and temperature on the structure of bicelles, which is important to design tailored systems. As the fraction of ChEO10 (XC) was increased, a bimodal particle size distribution with a small particle size of several tens of nanometers and a large particle size of several hundred nanometers was obtained, and only small particles were observed when XC ≥ 0.6, suggesting the formation of significant structure transition (liposomes to bicelles). The small-angle neutron scattering (SANS) spectrum for these particles fitted a core-shell bicelle model, providing further evidence of bicelle formation. A transition from a monomodal to a bimodal size distribution occurred as the temperature was increased, with this transition taking place at lower temperatures when higher SL-ChEO10 concentrations were used. SANS showed that this temperature-dependent size change was reversible, suggesting the SL-ChEO10 bicelles were stable against temperature, hence making them suitable for several applications. View Full-Text
Keywords: bicelle; temperature robustness; lecithin; phospholipid; nonionic surfactant; dynamic light scattering; small-angle neutron scattering; self-assembly; nano colloid bicelle; temperature robustness; lecithin; phospholipid; nonionic surfactant; dynamic light scattering; small-angle neutron scattering; self-assembly; nano colloid
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MDPI and ACS Style

Aramaki, K.; Adachi, K.; Maeda, M.; Mata, J.; Kamimoto-Kuroki, J.; Tsukamoto, D.; Konno, Y. Formulation of Bicelles Based on Lecithin-Nonionic Surfactant Mixtures. Materials 2020, 13, 3066. https://doi.org/10.3390/ma13143066

AMA Style

Aramaki K, Adachi K, Maeda M, Mata J, Kamimoto-Kuroki J, Tsukamoto D, Konno Y. Formulation of Bicelles Based on Lecithin-Nonionic Surfactant Mixtures. Materials. 2020; 13(14):3066. https://doi.org/10.3390/ma13143066

Chicago/Turabian Style

Aramaki, Kenji, Keita Adachi, Miho Maeda, Jitendra Mata, Junko Kamimoto-Kuroki, Daisuke Tsukamoto, and Yoshikazu Konno. 2020. "Formulation of Bicelles Based on Lecithin-Nonionic Surfactant Mixtures" Materials 13, no. 14: 3066. https://doi.org/10.3390/ma13143066

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