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Special Issue "Glutathione Metabolism"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (30 June 2019).
Dr. Fabio Ciccarone E-Mail
Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
Prof. Sara Baldelli E-Mail
IRCCS San Raffaele Pisana, Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy
The phenomenal rate of expansion in the field of redox-regulated mechanisms justifies the main aim of this issue, which is to provide an overview of the biochemistry of thiol redox homeostasis centered in the glutathione and of its role in cellular metabolism. Indeed, no aspect related to this tripeptide is canonical, starting from the characteristic enzymatic synthesis, to the resistance to degradation and capability of oxidation. Moreover, its high intracellular concentration stands for an unavoidable intersection with cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation, detoxification and death. The incipient concept is related to the field of emerging tools in “nanotechnologies” to achieve targeted drug delivery, where glutathione has clearly penetrated fields other than biology. In this context, glutathione has emerged as a potential candidate to facilitate the receptor-mediated transcytosis of nanocarriers, especially at the blood–brain barrier. Another emerging function is related to omics, specifically referred to as exposomics, which is a proposed term and the field of study of the disease-causing effects of environmental factors. The well-established concept that redox modifications of the proteome provide a system to sense, avoid and defend against environmental toxicants is again putting glutathione at the center stage of the adaptive interface of the functional genome and the exposome. As a consequence, knowledge on the role of glutathione metabolism is never updated but is instead increasing in parallel with deeper understanding of biochemical processes and with the utilization of more sophisticated techniques.
It is, therefore, a pleasure to invite timely review papers, as well as high quality studies, on glutathione systems and their widespread implications in cellular signaling (e.g. cell death pathways and inflammation), pathophysiology (ranging from cancer to neurodegeneration), therapeutic approaches and drug delivery based on GSH or its derivatives, biomarker usage, and nutritional intersections other than antioxidant responses.
Prof. Dr. Maria Rosa Ciriolo
Dr. Fabio Ciccarone
Prof. Sara Baldelli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Redox signaling
- Redox proteome
- Metabolic disease