Green and Sustainable Chemical Processes

Topic Information

Dear Colleagues,

The way we transform material substances into many different forms has changed over the years and has continued to change since ancient times as a result of ideas, aspirations, ambitions, or simply by chance. At present, cutting-edge solutions are required to meet “Net Zero” targets and/or solutions based on “Industry 4.0” technologies. This topic is open to all. Let’s work together to define and redefine “sustainability” and “green” in chemical and biochemical processing. Subjects of interest include, but are certainly not limited to, the following:

• Advanced manufacturing technologies
• Advanced materials and nanomaterials 
• Bioactive compounds 
• Green solvents 
• Smart sensors
• Biofuels 
• Residue reutilization 
• Waste minimization 
• Simulation and integration
• Carbon footprint and eco-industry 
• Life cycle assessment

Dr. Iuliana Deleanu
Dr. Cristina Busuioc
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Catalysts catalysts	3.8	6.8	2011	13.9 Days	CHF 2200	Submit
ChemEngineering ChemEngineering	2.8	4.0	2017	32.8 Days	CHF 1600	Submit
Chemistry chemistry	2.4	3.2	2019	17.2 Days	CHF 1800	Submit
Materials materials	3.1	5.8	2008	13.9 Days	CHF 2600	Submit
Molecules molecules	4.2	7.4	1996	15.1 Days	CHF 2700	Submit
Processes processes	2.8	5.1	2013	14.9 Days	CHF 2400	Submit
Sustainability sustainability	3.3	6.8	2009	19.7 Days	CHF 2400	Submit
Clean Technologies cleantechnol	4.1	6.1	2019	33.5 Days	CHF 1600	Submit

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All Catalysts ChemEngineering Chemistry Materials Molecules Processes Sustainability Clean Technol.

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Open AccessArticle

Immobilized Phosphotriesterase as an Enzymatic Resolution for Sofosbuvir Precursor

by Weerapha Panatdasirisuk, Suthathip Phetlum, Thanat Tiyasakulchai, Nitipol Srimongkolpithak, Tanaporn Uengwetwanit and Nongluck Jaito

Catalysts 2025, 15(4), 339; https://doi.org/10.3390/catal15040339 - 31 Mar 2025

Viewed by 183

Abstract

The enzymatic resolution of chiral sofosbuvir precursors is a critical step in producing stereoisomerically pure ProTide drugs, essential for their therapeutic efficacy. In this study, a mutated phosphotriesterase (W131M-PTE) was immobilized onto various polymeric macroporous beads, including commercial immobead 150P (IB), modified (IB-EDA [...] Read more.

The enzymatic resolution of chiral sofosbuvir precursors is a critical step in producing stereoisomerically pure ProTide drugs, essential for their therapeutic efficacy. In this study, a mutated phosphotriesterase (W131M-PTE) was immobilized onto various polymeric macroporous beads, including commercial immobead 150P (IB), modified (IB-EDA and IB-MTD), and synthetic polyacrylamide (PAM) beads functionalized with glutaraldehyde (PAM-GA) or 1-Ethyl-3-(3-dimethyl aminopropyl) carbodiimide (PAM-EDC). The immobilization efficiency, stability, and reusability of the enzyme were systematically evaluated. Among the tested supports, PAM-EDC demonstrated superior performance, retaining high enzymatic activity across multiple cycles and achieving a 92% yield of the (Sp)-diastereomer. The study highlights the potential of immobilized W131M-PTE as a cost-effective and scalable solution for chiral separation in pharmaceutical manufacturing, with implications for broader applications in ProTide drug production. Full article

(This article belongs to the Topic Green and Sustainable Chemical Processes)

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