Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening cerebrovascular condition characterized by a dynamic clinical course spanning distinct pathophysiological stages, including aneurysm rupture, early brain injury (EBI), delayed cerebral v...
The fall armyworm (Spodoptera frugiperda) is a significant agricultural pest with a broad host range and adaptability, posing challenges to pest management worldwide. To elucidate the molecular mechanisms underpinning their development and resilience...
Achieving sustainable rice production is essential for food security, rural livelihoods, and the resilience of rice-based food systems that supply raw materials to the food processing industry. Improving technical efficiency (TE) at the farm level is...
Flood disasters evolve through distinct stages, and emergency supply demand shifts accordingly, rendering static post-disaster distribution plans inadequate for stage-specific rescue needs. This study develops a multi-stage location-routing optimizat...
RGB–thermal detection benefits from both cross-modal feature calibration and the recovery of fine-scale structural evidence. However, spatial responses produced during these operations are often used only to regulate intermediate features. We p...
The cotton aphid Aphis gossypii is a globally significant agricultural pest that threatens crop production through its prolific reproduction. While the parasitoid wasp Binodoxys communis offers promising potential for biological control, the molecula...
Salt stress is one of the most severe environmental stresses limiting the productivity of crops, including rice. However, there is a lack of information on how salt-stress sensitivity varies across different developmental stages in rice. In view of t...
Drought stress severely limits the productivity of sweet potato (Ipomoea batatas L.), yet the stage-specific molecular mechanisms of its adaptation remain poorly understood. Therefore, we integrated transcriptomics and extensive targeted metabolomics...
The planktonic dispersal of Limnoperna fortunei larvae and the byssal attachment of juveniles and adults make this species a major invasive biofouling species in water-conveyance infrastructure, while artificial hydraulic connectivity further facilit...
The restoration of karst rocky desertification is reflected not only in the reduction in severely degraded areas but also in the stability of the restoration process and the potential risk of future reversal. Taking southeastern Yunnan, China, as the...
19 July 2021
Since most of the early signs of psychological distress are nonspecific and often under the threshold of a diagnosable disorder, especially in early adolescence, a dimensional and transdiagnostic approach is needed to guide early interventions. In th...
Flower bud differentiation is crucial to reproductive success in plants. In the present study, RNA-Seq and nutrients quantification were used to identify the stage-specific genes for flower bud differentiation with buds which characterize the marked...
Background: Gallbladder cancer (GBC) is a highly aggressive malignancy characterized by a poor prognosis, particularly in its advanced stages. While microRNAs (miRNAs) regulate cancer progression, their specific role in the transition from early to a...
The apicomplexan zoonotic parasite Toxoplasma gondii has three infective stages: sporozoites in sporulated oocysts, which are shed in unsporulated form into the environment by infected felids; tissue cysts containing bradyzoites, and fast replicating...
In this study, we investigated global changes in miRNAs of Meloidogyne incognita throughout its life cycle. Small RNA sequencing resulted in approximately 62, 38, 38, 35, and 39 Mb reads in the egg, J2, J3, J4, and female stages, respectively. Overal...
The Colorado potato beetle is a notorious agricultural pest with remarkable adaptability and insecticide resistance. This study conducted comprehensive transcriptome analysis across multiple developmental stages and tissues, focusing on the cytochrom...
While insects harbor gut microbial associates that perform various functions for the host, lepidopterans have not been considered as prime examples of having such relationships. The western bean cutworm, Striacosta albicosta (Lepidoptera: Noctuidae),...
In animals, growth and development are strongly correlated with the gut microbiota. The gut of the economically important marine crab (Scylla paramamosain) harbors a diverse microbial community, yet its associations with the surrounding environment,...
Oudemansiella raphanipes is a prized edible mushroom renowned for its “three-high, one-low” nutritional profile (high protein, fiber, vitamins; low fat). However, the stage-specific molecular dynamics governing its development and their p...
Maize production in the black soil region of Northeast China is highly vulnerable to drought and flood stress, yet stage-specific mechanisms under rain-fed conditions remain unclear. Daily meteorological records from 1951 to 2024 were used to calcula...
Background/Objectives: The objective of this study was to investigate the metabolomic profiles of patients with colorectal cancer (CRC) across various stages of the disease. Methods: The plasma samples were obtained from 255 subjects, including patie...
Background/Objectives: Lymphedema is a chronic condition caused by impaired lymphatic function that is characterized by fluid accumulation with progression to tissue thickening and fibrosis. Although various noninvasive assessment methods have been p...
Brassinosteroids are recognized regulators of anthocyanin and proanthocyanidin biosynthesis in grapevine; however, their spatiotemporal effects remain insufficiently characterized. This study examined the stage-specific impacts of exogenous 24-epibra...
Nosema ceranae is one of the fungal parasites of Apis mellifera. It causes physical and behavioral effects in honey bees. However, only a few studies have reported on gene expression profiling during A. mellifera infection. In this study, the transcr...
The red flower aphid (Uroleucon gobonis) is a significant agricultural pest causing damage via direct feeding and virus transmission. Chemical sensory proteins (CSPs) are critical for insecticide resistance, mediating the detection of semiochemicals...
Fungal aerosols are critical yet understudied bioaerosol components in enclosed poultry environments, particularly during winter when ventilation is restricted. This study investigated stage-specific variations in fungal aerosol concentration, size d...
This study investigated the expression profiles of microRNA-like RNAs (milRNAs) in Fusarium oxysporum HS2 (FoHS2), a key pathogen causing Apple replant disease (ARD), across spore to mycelium formation stages. Using small RNA sequencing (sRNA-seq) an...
Endometrial cancer (EC) is a complex gynecologic malignancy that requires a deeper understanding of its molecular basis to improve therapeutic strategies. In this study, we investigated the role of fatty acid (FA) reprogramming in the progression of...
Paradoxical insomnia (PI) is characterized by a discrepancy between subjective sleep complaints and objectively preserved sleep, yet its autonomic mechanisms remain poorly understood. This study examined stage-specific autonomic characteristics of PI...
The lack of scientific methods for selecting monitoring indicators and equipment undermines the efficiency of forest fire emergency response. To address this gap, we developed a novel evaluation model for emergency monitoring indicators based on the...
To quantitatively evaluate the environmental performance of a Chinese solar greenhouse (CSG) in Northern China during the autumn–winter season and explore its matching relationship with the growth requirements of autumn–winter tomato prod...
Converting biological strategies into practical design principles during the Discover–Abstract phase of the Biomimicry Design Spiral (BSD) presents a considerable obstacle, particularly for designers lacking a biological background. This resear...
Multidimensional trait frameworks are increasingly used to understand how plant functional strategies change across ontogeny. However, whether leaf economic, stomatal, and non-structural carbohydrate traits show consistent or dimension-specific ontog...
Background/Objectives: Proso millet (Panicum miliaceum L.), a drought-tolerant cereal vital to semi-arid agriculture, faces severe yield losses from head smut disease caused by the pathogen Sporisorium destruens. Although partial resistance exists, t...
Stage-specific embryonic antigen 1 (SSEA-1) is an antigenic epitope (also called CD15 antigen) defined as a Lewis X carbohydrate structure and known to be expressed in murine embryonal carcinoma cells, mouse embryonic stem cells (ESCs), and murine an...
This review introduces and elaborates a novel temporal paradigm, the “Gout Inflammation Time Programming” model, conceptualized through the Gout-STAT™ framework. This model redefines gout inflammation as a dynamic continuum progress...
Amelogenin comprises ~90% of enamel proteins; however, the involvement of Amelx transcriptional activation in regulating ameloblast differentiation from induced pluripotent stem cells (iPSCs) remains unknown. In this study, we generated doxycycline-i...
Asthma is a chronic respiratory disease characterized by airway hyperresponsiveness, obstruction, and persistent inflammation, arising from complex interactions among genetic, epigenetic, immune, and environmental factors. To elucidate the stage-spec...
The large-scale cultivation of medicinal plants generates substantial agricultural by-products that are often discarded. A notable example is the floral biomass of Bupleurum chinense DC. (B. chinense), which is routinely removed during cultivation to...
Migratory flyways sustain waterbird populations by linking critical habitats across their annual cycle. However, stage-specific impacts of climate change on these habitats remain poorly understood. We integrated species distribution models with annua...
A growing leaf can be divided into three sections: division zone, elongation zone, and maturation zone. In previous studies, low nitrogen (LN) inhibited maize growth and development, especially leaf growth; however, the gene expression in response to...
Ankylosing spondylitis (AS) is a type of chronic rheumatic immune disease, and the crucial point of AS treatment is identifying the correct stage of the disease. However, there is a lack of effective diagnostic methods for AS staging. The primary obj...
Triploid turbot (Scophthalmus maximus) exhibit superior growth and survival, yet the molecular basis of their sterility—a key trait for aquaculture—remains largely unexplored. This study investigated ovarian development and transcriptomic...
Insect cuticle is critical for the environmental adaptability and insecticide resistance of insects. However, there is no clear understanding of the structure and protein components of the cuticle during each developmental stage of holometabolous ins...
Collagen V is a minor fibrillar collagen that regulates type I collagen fibrillogenesis; however, its time-dependent role during the stages of adult tendon healing remains unclear. We investigated the stage-specific effects of inducible Col5a1 knockd...
Heme released during blood digestion represents a major oxidative challenge for hematophagous insects, promoting the generation of reactive oxygen species (ROS) and redox imbalance. Although Aedes aegypti has evolved specialized mechanisms to mitigat...
Background: The early and accurate classification of ischemic stroke stages on computed tomography (CT) remains challenging due to subtle attenuation differences and significant scanner variability. This study developed a neural network framework to...
Placental development plays a pivotal role in ensuring successful pregnancy outcomes, yet its molecular regulatory mechanisms in sheep remain poorly characterized. This study aimed to systematically investigate stage-specific proteomic dynamics and f...
Calcineurin (CaN), a Ca2+-dependent phosphatase, plays key roles in eukaryotic cell signaling. We investigated whether Leishmania amazonensis’ two infective forms—promastigotes and amastigotes—exhibit differences in CaN expression,...
Ovine Respiratory Complex (ORC) is a major cause of lamb mortality in intensive and semi-intensive sheep production systems. Its multifactorial etiology, involving bacterial and viral pathogens together with host and environmental factors, complicate...
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