Advanced Research of Non-Coding RNAs in Health and Disease

Dear Colleagues,

Non-coding RNAs (ncRNAs), are transcripts encoded by the genome that are largely not translated into proteins. They play essential roles in regulating gene expression and cellular signaling pathways, and alterations in their expression levels are associated with numerous diseases, including cancer.

Abundant and functionally important classes of ncRNAs include transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), and several small RNAs such as microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), PIWI-interacting RNAs (piRNAs), small nuclear RNAs (snRNAs), extracellular RNAs (exRNAs), small Cajal body-specific RNAs (scaRNAs), circular RNAs (circRNAs) as well as long non-coding RNAs (lncRNAs).

The presence of ncRNAs in the cytoplasm, nucleus, and extracellular space, where they can act as signaling molecules, adds another layer of regulatory complexity, as ncRNAs may have distinct targets and functions depending on their cellular localization.

The aim of this Special Issue is to collect original research articles, reviews and commentaries focused on the recent advances in the field of ncRNAs in both health and disease. A deeper understanding of the complex regulatory networks established by ncRNAs may ultimately provide a rich source of novel therapeutic targets.

Dr. Celestino Sardu
Guest Editor

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