This study aimed to establish a physiologically relevant in vitro-in vivo correlation (IVIVC) model reflecting site-dependent dissolution kinetics for sildenafil based on population-pharmacokinetic (POP-PK) modeling. An immediate release (IR, 20 mg)...
The mobility of arsenic (As) and antimony (Sb) in soils is controlled by several processes (adsorption/desorption, (co)precipitation/dissolution and oxidation/reduction), depending on various environmental factors that are often convoluted and site-d...
The widespread use of clay minerals and clays in environmental engineering, industry, medicine, and cosmetics largely stems from their adsorption properties and surface charge, as well as their ability to react with water. The dissolution and growth...
Alite dissolution plays a crucial role in cement hydration. However, quantitative investigations into alite powder dissolution are limited, especially regarding the influence of chemical admixtures. This study investigates the impact of particle size...
The utilization of waste as raw materials in the production of functional materials is a growing area of interest to promote global sustainable growth. This work studied the microstructure, chemical properties, and phosphorus (P) dissolution efficien...
Mechanistic understanding and prediction of solute adsorption from fluids onto mineral surfaces is relevant for many natural and technical processes. Mineral surfaces in natural systems are often exposed to fluids at non-equilibrium conditions result...
The materials used to conduct kinetic study on the leaching of silver in the S2O32−-O2-Cu2+ system were mining residues (tailings) from the Dos Carlos site in the State of Hidalgo, Mexico, which have an estimated concentration of Ag = 71 g∙ton−1. The...
We have systematically analyzed the solution and aggregation characteristics of yttrium (Y), lanthanum (La), lutetium (Lu) and potassium (K) on symmetrically inclined tungsten (W) grain boundary (GB) Ʃ5(310)/[001] by first principles calculation...
Purpose: Most therapeutic agents have limitations owing to low selectivity and poor solubility, resulting in post-treatment side effects. Therefore, there is a need to improve solubility and develop new formulations to deliver therapeutic agents spec...
Uncovering the characteristics of groundwater pollution and its driving mechanisms are crucial for maintaining its ecological functions. This study focuses on hydrochemical changes and their driving factors in groundwater from different aquifers in i...
Cadmium (Cd) is one of the most toxic transition metals for living organisms. Thus, effective measures to remediate Cd from water and soils need to be developed. Cd immobilization by alumina and mixtures of alumina and smectite have been analyzed exp...
The contemporary retreat of glaciers results in the development of glacial forelands which constitute excellent areas for studies on the initial stages of weathering. This research concentrates on weathering rinds developed on glacially abraded Dachs...
The Alternative Buffer Material ABM5 experiment is an in situ medium-scale experiment performed at Äspö Hard Rock Laboratory (HRL) conducted by SKB in Sweden with the aim of analysing the long-term stability of bentonites used as an enginee...
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently administered orally with modified-release formulations. The attainment of modified-release drugs is commonly achieved through the coprecipitation of the active principle with a biodegradab...
Sustaining human presence on the Moon depends on access to strategic metals, which can be achieved by directly utilizing extraterrestrial resources through in situ resource utilization (ISRU). This study presents novel insights and preliminary result...
The concentrations of natural radioactive elements in the groundwater environment are regulated by several factors, including aquifer geology, groundwater hydrochemical properties, and changes in environmental conditions. Many studies have explored t...
Proton binding (i.e., charging) isotherms of halloysite nanotubes (HNT) were determined from cycled acid-base potentiometric titrations in KCl solution at constant ionic strengths (0.01, 0.10, 1.00 mol dm−3). The isotherms measured in the pH cy...
Light non-aqueous phase liquids (LNAPLs) are significant groundwater contaminants whose migration in aquifers is governed by dynamic groundwater level fluctuations. This study establishes a multiphase flow coupling model integrating hydraulic, gaseou...
Several locally acting colon-targeted products to treat colonic diseases have been recently developed and marketed, taking advantage of gastrointestinal physiology to target delivery. Main mechanisms involve pH-dependent, time-controlled and/or enzym...
Migraine is now the sixth most common disease in the world and affects approximately 15% of the population. Non-steroidal anti-inflammatory drugs, including ketoprofen, diclofenac sodium, and ibuprofen, are often used during migraine attacks. Unfortu...
(Li0.4Co0.2Ni0.2Cu0.2Zn0.2)WO4 high-entropy ceramics were prepared by a conventional solid-state reaction route. This study thoroughly explores the interrelationships between their crystal structure, bond properties, and microwave dielectric characte...
Soil acidification threatens agroecosystems, yet the coupled, soil-specific proton-buffering mechanisms in permanent-charge soils (PCSs) and variable-charge soils (VCSs) remain insufficiently quantified. This study systematically investigated surface...
A large-scale immersion experiment was carried out to assess the collapsibility characteristics of loess in Bu Li village located in the Weibei Loess Tableland, and the seepage characteristics and collapsibility evolution of loess were determined. Th...
Zinc pyrithione (ZnPT) is an anti-fungal drug delivered as a microparticle to skin epithelia. It is one of the most widely used ingredients worldwide in medicated shampoo for treating dandruff and seborrheic dermatitis (SD), a disorder with symptoms...
The plasticity and hardness of metals are largely dependent on how dislocation interacts with solute atoms. Here, taking bcc molybdenum (Mo) as the example, the interaction of interstitial solutes carbon (C) and oxygen (O) with screw dislocation, and...
The corrosion behavior of metal matrix composites (MMCs) is accelerated by the inclusion of reinforcements. Hence, this study investigates the corrosion behavior of MMCs produced from Al 6063 matrix alloy with reinforcement particulates of silicon ca...
Successful drug delivery by mucoadhesive systems depends on the polymer type, which usually gets adherent on hydration. The intended polymers must sustain the association with biomembranes and preserve or accommodate the drug for an extended time. Th...
Pincer ligands occupy three coplanar sites at metal centers and often support both stability and reactivity. The five-coordinate [FeIIICl2(tia-BAI)] complex (tia-BAI− = 1,3-bis(2’-thiazolylimino)isoindolinate(−)) was considered as a...
Chitin is an effective sorbent which can be used in environmental monitoring, beyond obvious applications in withholding metal-containing pollutants from wastewater- or nuclear fuel reprocessing flows, since background levels in (purified) chitin are...
Microencapsulation is highly attractive for oral drug delivery. Microparticles are a common form of drug carrier for this purpose. There is still a high demand on efficient methods to fabricate microparticles with uniform sizes and well-controlled pa...
The reactive transport of hexavalent chromium (Cr(VI)) in anthropogenically disturbed sites (e.g., mine waste rock dumps, chromium salt industrial sites) is critically influenced by physico-chemical heterogeneity, yet the interplay between physical a...
Tenoxicam (TNX) is a new non-steroidal anti-inflammatory drug that shows a superior anti-inflammatory effect and has the advantages of a long half-life period, a fast onset of action, a small dose, complete metabolism, and good tolerance. Some compou...
Zircon grains from various metagranitoids (plagio- and monzo-granites, gneisses, metasomatic rocks, and pegmatoid veins) from the Skal’noe and Dikoe sites of the Litsa uranium ore area (Kola Region, Russia) were studied in order to reconstruct...
Widespread cold seeps along continental margins are significant sources of dissolved carbon to the ocean water. However, little is known about the methane turnovers and possible impact of seepage on the bottom seawater at the cold seeps in the South...
High-entropy alloys (HEAs) provide a broad compositional space for tuning phase stability and surface durability. CoCrFeNiMnx (x = 0.5, 1.0, 1.5, and 2.0) alloys were fabricated by vacuum arc melting and characterized by X-ray diffraction (XRD), opti...
The present paper deals with a field experiments on evaporite rock samples and groundwater investigations in the Quinis test site, a hamlet of the Enemonzo municipality in NE Italy, were sinkholes occurred in the past and are still occurring causing...
Antibiotics damage the gut microbiome, which can result in overgrowth of pathogenic microorganisms and emergence of antibiotic resistance. Inactivation of antibiotics in the small intestine represents a novel strategy to protect the colonic microbiot...
The development of “biohybrid” drug delivery systems (DDS) based on mesenchymal stem/stromal cells (MSCs) is an important focus of current biotechnology research, particularly in the areas of oncotheranostics, regenerative medicine, and t...
26 August 2021
Mangroves are among the most relevant ecosystems in providing ecosystem services because of their capacity to act as sinks for atmospheric carbon. Thus, restoring mangroves is a strategic pathway for mitigating global climate change. Therefore, this...
Fluid–rock interaction experiments between a biotite-rich schist (from Mt. Calamita Formation, Elba Island, Italy) and B-bearing aqueous fluids were carried out at 500–600 °C and 100–130 MPa. The experiments have been carried out in order to reproduc...
This study provides a comprehensive evaluation of naturally occurring radionuclides—radium-226 (226Ra), thorium-232 (232Th), and potassium-40 (40K)—in groundwater systems across the Nile Valley regions of Upper Egypt, based on the analysi...
Monitoring the hydrochemistry of groundwater and the H-O isotopes in the Jingpo Lake volcanic area, China, is fundamental to studying the mechanisms of volcanic and seismic events, as well as the associated hazards. To study the hydrogeochemistry of...
Co/Fe-based layered double hydroxides (LDHs) are among the most promising materials for electrochemical applications, particularly in the development of energy storage devices, such as electrochemical capacitors. They have also been demonstrated to f...
Saline aquifers have been used for CO2 storage as a dedicated greenhouse gas mitigation strategy since 1996. Depleted gas fields are now being planned for large-scale CCS projects. Although basalt host reservoirs are also going to be used, saline aqu...