Applications of Crystal Engineering in Drug Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 36250
Special Issue Editor
Interests: amorphous polymeric solid dispersions; pulmonary drug delivery; oral drug delivery; co-crystals; co-amorphous dispersions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Manuscripts are invited for publication in a Special Issue of Pharmaceutics entitled "Applications of Crystal Engineering in Drug Delivery". This Special Issue is focused on the use of crystal engineering methods to improve drug properties such as solubility and dissolution rate for optimum drug delivery. Crystal engineering is a broad area of research that included crystal habit modification, polymorphism, solid dispersions, and salt formation. All these pre-formulation and formulation techniques entail that the drug can be modified using methods such as solvent evaporation or dry methods such as mechanochemical activation. Often, the drug properties can be significantly altered when the crystalline structure is altered or even completely vanish, such as in the case of amorphous form formation. The outcome of such modifications affects physical properties and can have a dramatic impact on physiological properties, such as bioavailability and absorption. Drug delivery applications include various routes, such as oral, pulmonary, ophthalmic, buccal, vaginal, transdermal, and parenteral drug delivery. Recent advances in this area of research have shown potential application of these techniques to use crystal engineering to achieve targeted drug delivery for novel molecules such as anticancer drugs, antimicrobials, and vaccines.
Dr. Hisham Al-Obaidi
Guest Editor
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Keywords
Manuscripts are invited for publication in a Special Issue of Pharmaceutics entitled "Applications of Crystal Engineering in Drug Delivery". This SI is focused on the use of crystal engineering methods to improve drug properties such as solubility and dissolution rate for optimum drug delivery. Crystal engineering is a broad area of research that included crystal habit modification, polymorphism, solid dispersions, and salt formation. All these pre-formulation and formulation techniques entail that the drug can be modified using methods such as solvent evaporation or dry methods such as mechanochemical activation.
Drug delivery applications include various routes, such as oral, pulmonary, ophthalmic, buccal, vaginal, transdermal, and parenteral drug delivery. Recent advances in this area of research have shown potential application of these techniques to use crystal engineering to achieve targeted drug delivery for novel molecules such as anticancer drugs, antimicrobials, and vaccines.
- crystal engineering
- polymorphism
- solvates
- solid dispersions
- poorly-soluble drugs
- amorphous
- crystallinity
- polymer-drug mixtures
- solid dosage forms
- dissolution rate
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