Biopolymeric microparticles have been widely used for long-term release formulations of short half-life chemicals or synthetic peptides. Characterization of the drug release from microparticles is important to ensure product quality and desired pharm...
Currently, a wide variety of complex non-oral dosage forms are entering the global healthcare market. Although many assays have been described in recent research, harmonized procedures and standards for testing their in vitro performance remain widel...
The high-precision gravitational reference sensor, which hosts a heavy test mass (TM) surrounded by electrodes with a relatively large gap, is crucial in all high-sensitivity drag-free sensors. Consequently, a dedicated locking mechanism is needed to...
Metal/polymer reactive materials have been studied and applied in a wide range of ways in recent years. This type of material is insensitive under normal conditions but reacts violently and releases a large amount of chemical energy under high-speed...
In the context of a space-based gravitational wave detection mission, the grabbing positioning and release mechanism (GPRM) is tasked with ensuring that the test mass (TM) is securely fixed in the appropriate configuration at the time of the satellit...
The use of nanoadditives in food contact materials requires risk assessment to ensure consumers’ safety. The evaluation of health risk is based on the combination of two elements: hazard and exposure. For nanomaterials (NM) used as additives in...
Background: The pharmaceutical industry is shifting from end-product testing towards real-time release testing. This approach is based on the continuous collection of process data and product information, which is finally utilized for the release dec...
The aim of our study was to adapt the analytical quality by design (AQbD) approach to design an effective in vitro release test method using USP apparatus IV with a semi-solid adapter (SSA) for diclofenac sodium hydrogel. The analytical target profil...
The release profiles of active substances from microspheres are one of the most important features in solid lipid microparticles (SLM) characterization. Unfortunately, the results of the dissolution tests are largely dependent on the chosen method an...
This study focuses on how to define an Analytical Target Profile (ATP) which is intended for use in practice and on facilitating the selection of in vitro release test (IVRT) technology for diclofenac sodium topical hydrogel and cream. The implementa...
Groundwater quality assessment during well drilling could be biased by transient contamination from drilling equipment and fluids. To address this issue, batch leaching tests, sequential filtration experiments, and field validation were combined. Bat...
Precocious puberty in girls is defined as the onset of pubertal changes before 8 years of age, and gonadotropin-releasing hormone (GnRH) agonist treatment is available for central precocious puberty (CPP). The gold standard for diagnosing CPP is the...
Reductions in tuberculosis (TB) incidence require identification of individuals at high risk of developing active disease, such as those with recent Mycobacterium tuberculosis (Mtb) infection. Using a prospective household contact (HHC) study in Kamp...
Despite the threat posed by tuberculosis (TB) to the protected European bison (Bison bonasus), no validated TB tests exist for this species. This pilot study evaluates two tests based on detecting cellular immunity for this purpose: interferon gamma...
Although colloidal carriers have been in the pipeline for nearly four decades, standardized methods for testing their drug-release properties remain to be established in pharmacopeias. The in vitro assessment of drug release from these colloidal carr...
Early diagnosis of degenerative cervical myelopathy (DCM) is desirable, as delayed treatment can cause irreversible spinal cord injury and subsequent activity of daily living (ADL) impairment. We attempted to develop a straightforward and accurate di...
The corrosion resistance of nanostructured nitinol (NiTi) was investigated using long-term tests in solutions simulating physiological fluids at static conditions, reflecting the material structure and metal concentration in the solutions. Mechanical...
Background and objective: Lithuania belongs to the group of countries with a high-incidence of tuberculosis (TB). Some scientific studies show that the interferon-gamma release assay is more accurate and correlates more highly with TB exposure as com...
In recent years, oral tobacco-derived nicotine (OTDN) pouches have emerged as a new oral tobacco product category. They are available in a variety of flavors and do not contain cut or ground tobacco leaf. The on!® nicotine pouches fall within thi...
31 October 2025
Background: Identifying latent tuberculosis infection (LTBI) is critical for pediatric TB control in China, especially among students from high-burden areas. With no gold-standard test, we compared the tuberculin skin test (TST) and interferon-gamma...
Background: Children have an increased risk of developing active tuberculosis (TB) after exposure to Mycobacterium tuberculosis (M.tb), and they are more likely to develop the most severe forms of TB. Rapid diagnosis and treatment of latent M.tb infe...
This study aimed to assess the magnitude of anti-SARS-CoV-2 immunoglobulin G (IgG) titers and Interferon-Gamma Release Assay (IGRA) test results following administration of booster BNT162b2 in 48 ChAd-primed participants (vaccination schedule: ChAd/C...
Background: The world health goal of eliminating tuberculosis (TB) is heavily hinged on timely and efficient diagnosis and treatment. The interferon-γ release assays (I.G.R.A.s) can diagnose Mycobacterium tuberculosis infection and offer an alt...
Polysaccharide hydrogel-based fertilizer carriers have emerged as promising alternatives to conventional synthetic systems due to their biodegradability, tunable physicochemical properties, and ability to regulate nutrient release through structure&n...
Improvements in mechanical properties and a shift of focus towards esthetic dentistry led to the application of dental resins in various areas of dentistry. However, dental resins are not inert in the oral environment and may release monomers and oth...
In vitro release testing (IVRT) provides an efficient method for the evaluation of drug release from semi-solid formulations. The aim of this research was to develop and validate a discriminatory IVRT system using vertical diffusion cells (VDCs) to a...
(1) Background: There is an ongoing discussion on the elution efficacy of antibiotic-impregnated cements. Our experiments were intended to clarify if there are differences in the antibiotic elution of HPLC compared with inhibition zone testing using...
The interferon-gamma release assay (IGRA) is used to diagnose cases of feline mycobacteriosis, but the use of serial testing to monitor treatment responses has not been evaluated in this species. From a population of cats that underwent IGRA testing...
The increasing prevalence of esophageal disease highlights the clinical relevance of novel, long-lasting mucoadhesive oral dosage forms. The EsoCap device enables targeted local application of films in the esophagus. Biorelevant test systems such as...
The rapid expansion of RNA therapeutics requires analytical methods that resolve molecular integrity, heterogeneity, and process-related impurities. Capillary electrophoresis (CE) provides direct RNA separation with low sample consumption and can be...
This paper proposes a simple model for predicting the development of deleterious expansion from alkali-silica reaction (ASR) in long-service concrete structures. This model is based on some composition and reactivity parameters related to ASR, includ...
Flame-retardant coatings and films are widely used to delay flame spread on interior finishing and wood-based materials; however, their fire effluent toxicity has not been sufficiently characterized, and direct comparisons between these product types...
19 August 2022
Patients with neck pain may experience cervical myelopathy, this may be detected by clinical myelopathic signs, although they did not have any symptom of myelopathy, except having neck pain. Decreasing physical performance is one symptom of cervical...
The safety and efficacy of a generic medicine can be confirmed by demonstrating bioequivalence (BE) between the generic product and its reference listed drug (RLD) by measuring drug concentrations in the blood following administration. However, for t...
This article attempts to develop hydrogel systems containing two polymers, chitosan and methylcellulose, with somatotropin as the active substance. The aim of the study was to obtain a hydrogel preparation for the skin that releases a sufficient amou...
The Earthview BluBird continuous methane emissions monitoring system participated in single-blind controlled-release testing in 2022 and 2024, with the goal of evaluating the leak detection and quantification capabilities of these metal-oxide point s...
Electrical installations are a significant component of fire load inside a building, although they are often neglected in the overall fire safety analysis and are not subjected to any kind of fire safety evaluation of a building. A typical electrical...
This manuscript presents a systematic and detailed study of ion release from 45S5 bioactive glass to develop a methodology to directly monitor dissolved ions in a simulated fluid via inductively coupled plasma optical emission spectrometry (ICP OES)....
Naturally occurring asbestos (NOA) represents a matter of social and environmental concern due to its potential release in the atmosphere during rock excavation and grinding in quarry and road tunnel activities. In most cases, NOA occurs in serpentin...
This study evaluated how silicone release liners come away from butyl hot-melt pressure-sensitive adhesive (HMPSA) sealants. An application-specific integration peel test was conducted based on FINAT FTM 10 geometry. It kept the 180° geometry, th...
Long-acting injectables (LAIs) are widely used for chronic conditions such as schizophrenia, opioid use disorder, and HIV. Their prolonged efficacy improves adherence and reduces dosing frequency. Among these systems, poly(lactide-co-glycolide) (PLGA...
The drug release profile of drug-eluting stents (DESs) is affected by a number of factors, including the formulation, design, and physicochemical properties of the utilized material. DES has been around for twenty years and despite its widespread cli...
Sustained-release (SR) formulations may appear advantageous in first-in-human (FIH) study of innovative medicines. The newly developed SR matrix tablets require prolonged maintenance of API concentration in plasma and should be reliably assessed for...
The internal force state in concrete components is a crucial factor in evaluating the safety performance of existing buildings, bridges, and other concrete structures, while theoretical and numerical analysis of an ideal model may not accurately capt...
In order to reduce the influence of temperature deformation of large-size body-mounted radiators on the observation accuracy of space station telescopes and adapt to launch vibration loads, this paper proposes a floating combination stress release me...
Background: There is sufficient evidence to demonstrate the importance of local allergies in the various clinical conditions encompassed by allergic pathology. We sought to examine the frequency of Local Allergic Asthma (LAA) and to investigate wheth...
Adhesion between coatings and substrates is an important parameter determining the integrity and reliability of film/substrate systems. In this paper, a new and more refined theory for characterizing adhesion between elastic coatings and rigid substr...
A test method for controlling the stress release rate of the tunnel by adjusting the confining pressure is proposed based on the engineering background of Dongmachang No. 1 Tunnel of Huali Expressway to explore a suitable excavation method of soft ro...
Plastic and rubber based composites containing carbon black (CB) were investigated for the potential to release CB nano-particulates under stress conditions into food simulants. Nanocomposites were exposed to thermal, chemical, and mechanical stress,...
The stress release ratio of the surrounding rock in tunnel excavation is one of the most important indicators that affect the stress distribution and displacement of the surrounding rock. To determine the variation law of the stress release ratio of...
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