Tuberculosis: Novel Insights and Approaches to Tackle an Ancient Disease

Dear Colleagues,

Tuberculosis (TB) has plagued humankind throughout history. Its causative agent (mycobacterium tuberculosis) was first identified in 1882 and yet, around 140 years later, TB is still estimated to affect around ten million people worldwide each year. The availability of effective vaccines and treatments has been insufficient to control TB and it is predicted that disease elimination will not be achieved in the coming decades without fundamentally rethinking our approach to control.

Innovative tools and control approaches have emerged in recent years, providing great hope for global TB control. These include improved detection technologies and treatment regimens, as well as promising vaccine candidates. Ambitious screening programs and promising clinical trials related to TB detection and prevention have also been implemented in various regions, including Vietnam, Canada, the Marshall Islands, and Ghana.

However, a better understanding of TB epidemiology is critically needed to ensure that novel tools and approaches are used efficiently and to maximise their impact on the burden of TB. Many aspects of the disease remain poorly understood, including the impact of comorbidities such as diabetes or HIV and the risk represented by latent TB infection. The true extent of the disease is also unknown in most places due to imperfect case detection and reporting issues.

This Special Issue focuses on highlighting recent findings in TB epidemiology that provide key insights for future TB control. We invite submissions of reports on a wide range of studies, including local investigations, international collaborations, systematic reviews, statistical analyses, and mathematical modelling analyses.

Dr. Romain Ragonnet
Guest Editor

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