Flavocoxid is a blended extract containing baicalin and catechin with potent antioxidant and anti-inflammatory properties due to the inhibition of the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) enzymes, nuclear factor-κB (NF-κB), tum...
This paper presents a comparative study between the traditional phase shift (also referred to as the Single-Phase Shift (SPS)) and the Dual-Phase Shift (DPS) controlled Triple Active Bridge (TAB) converter. Being a multi-port DC-DC converter with fle...
Loneliness has a direct impact on mental and physical health. This is especially relevant to older adults. In prior studies, socially isolated older adults wanted technology that would help them feel more physically present even across distances, suc...
This work aims to determine how the nematic twist-bend phase (NTB) of bismesogens containing two rigid parts of cyanobiphenyls connected with a linking chain containing n = 7, 9, and 11 methylene groups behaves in mixtures with structurally similar c...
Background: Introducing haemodialysis (HD) treatment in a phased manner, with lower treatment times at the outset combined with pre-defined increments in treatment over a period of several weeks, reduces the early burden of treatment in patients with...
Municipal building refurbishment projects are carried out under conditions of high uncertainty and complexity, which often result in unsatisfying outcomes. In this research, a case study approach is used to provide a holistic presentation of the sour...
Promoting the use of solar energy resources has always involved the challenges of instability and supply–demand mismatch. The key to solving these issues is to efficiently store and utilize solar energy resources using high-performance heat sto...
The application prospect of a flow focusing/blurring nozzle is broad but research on gas-liquid flow inside the nozzle is not comprehensive. The gas-liquid mixing inside the nozzle is difficult to study by visualization experiment, so this paper prop...
Objective: This phase I study aimed to determine the maximal tolerated dose of cisplatin administered every 2 weeks with infusional 5-fluorouracil (5FU) and concurrent radiation therapy (RT) in patients after complete resection of gastric adenocarcin...
9 February 2021
Bridging studies are designed to fill the gap between two populations in terms of clinical trial data, such as toxicity, efficacy, comorbidities and doses. According to ICH-E5 guidelines, clinical data can be extrapolated from one region to another i...
Background/Objectives: We aimed to evaluate the efficacy of a flexible loading-phase treat-and-extend regimen using faricimab, in which the number of loading-phase intravitreal injections was tailored to individual disease activity. Methods: This obs...
26 October 2020
Bioelectrical impedance analysis (BIA)-derived phase angle (PhA) is a valuable parameter to assess physical health. However, the genetic and environmental aspects of PhA are not yet well understood. The present study aimed to estimate the heritabilit...
Videofluoroscopic swallowing study (VFSS) is a standard diagnostic tool for dysphagia. To detect the presence of aspiration during a swallow, a manual search is commonly used to mark the time intervals of the pharyngeal phase on the corresponding VFS...
Increasing peak power demand implies the increasing significance of energy storage. Technologies that efficiently store heat and cold are also important for increasing the share of renewables and improving the efficiency of heating, ventilation, and...
This open-label, uncontrolled, single-arm, multicenter, phase 3 study evaluated the efficacy and safety of incobotulinumtoxinA in Japanese patients with blepharospasm. Eligible patients received incobotulinumtoxinA injections at fixed doses (50, 75,...
Background: The optimal method of starting maintenance haemodialysis (HD) in patients with kidney failure is not known. We have compared early treatment characteristics, blood pressure trajectories, and selected dialysis-related safety events in pati...
Background/Objectives: Circulating influenza strains antigenically differing from vaccine antigens increase disease burden by decreasing vaccine efficacy. Nucleoside-modified mRNA (modRNA) influenza vaccines may facilitate rapid production allowing l...
A phase I study was performed to determine the recommended dose of carbon ion radiotherapy and 3D image-guided brachytherapy for histologically confirmed stage II (≥4 cm), III, or IVA cervical cancer. Dose-limiting toxicities (treatment-related toxic...
This paper experimentally investigates the direct integration of 3.15 kg of phase change materials (PCM) into a standard vapour compression system of variable cooling capacity, through an innovative lab-scale refrigerant-PCM-water heat exchanger (RPW...
Background and rationale. Pleural mesothelioma (PM) is a rare and aggressive neoplasm that originates from the pleural mesothelium and whose onset is mainly linked to exposure to asbestos, which cannot be attacked with truly effective therapies with...
In the present study, vortex-assisted matrix solid-phase dispersion (VA-MSPD) extraction was used to isolate the major bioactive compounds from H. arenarium. To reduce the negative environmental impact of the conventionally used organic solvents, fou...
Research on support for relatives of patients with Parkinsonism has mainly focused on caregivers, while preventive offers for non-caregiving relatives are lacking. Thus, the aim of this multicenter pilot study is to develop and assess the feasibility...
Cancer progression and mortality remain challenging because of current obstacles and limitations in cancer treatment. Continuous efforts are being made to explore complementary and alternative approaches to alleviate the suffering of cancer patients....
Objectives: This phase Ib study assessed the safety and compatibility of indirect oregovomab immunization and Toll-like-receptor-3 (TLR3) stimulation with immune adjuvant Hiltonol® (poly-ICLC) and induced clinically relevant CA125-specific anti-t...
Background: Aminopeptidase N (CD13) is present on tumor vasculature cells and some tumor cells. Truncated tissue factor (tTF) with a C-terminal NGR-peptide (tTF-NGR) binds to CD13 and causes tumor vascular thrombosis with infarction. Methods: We trea...
Early stereotactic body radiation therapy (SBRT) to the primary tumor combined with epidermal growth factor receptor tyrosine kinase inhibitor (EFGR-TKI) treatment may increase progression-free survival (PFS) by delaying resistance in patients with a...
This phase 1 trial (NCT01938846) determined the maximum tolerated dose (MTD) of the mTOR serine/threonine kinase inhibitor, BI 860585, as monotherapy and with exemestane or paclitaxel in patients with advanced solid tumors. This 3+3 dose-escalation s...
The work aims to numerically evaluate different injection configurations for the analysis of a two-phase flow behavior and evolution through a staggered Y-junction pipeline. To minimize agglomeration between inlets, the injection zones have a separat...
Background: CD-13 targeted tissue factor tTF-NGR is a fusion protein selectively inducing occlusion of tumor vasculature with resulting tumor infarction. Mechanistic and pharmacodynamic studies have shown broad anti-tumor therapeutic effects in xenog...
Loneliness is increasingly common, especially among older adults. Technology like mobile telepresence robots can help people feel less lonely. However, such technology has challenges, and even if people use it in the short term, they may not accept i...
Density functional theory (DFT) calculations have been performed to investigate the interfacial interactions of ionic liquids (ILs) on the α- and β-phases of phosphorene (P) and arsenene (As). Nine representative ILs based on the combinati...
Pharmacoproteomics is the study of disease-modifying and toxicity parameters associated with therapeutic drug administration, using analysis of quantitative and temporal changes to specific, predetermined, and select proteins, or to the proteome as a...
Focused-electron-beam-induced deposition (FEBID) is a powerful nanopatterning technique where electrons trigger the local dissociation of precursor molecules, leaving a deposit of non-volatile dissociation products. The fabrication of high-purity gol...
Liquid metal MHD (Magneto-Hydro-Dynamic) systems can be employed to produce electricity from a wide range of heat resources. In such a system, a low-boiling organic fluid and a high-temperature liquid metal fluid mix. The former evaporates, and carri...
We have simulated BiCoO
Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bend...
Background: There is little evidence that supports the registered high dose of dexamethasone used around docetaxel. However, this high dose is associated with considerable side effects. This study evaluates the feasibility of reducing the prophylacti...
Background: Phase ii data are increasingly being used as primary evidence for public reimbursement for oncologic drugs. We compared the frequency of reimbursement recommendations for phase ii and phase iii submissions and assessed for variables assoc...
Limited therapies exist for neurofibromatosis type 1 (NF1)-associated plexiform neurofibroma (PN). For this reason, the activity of vinblastine (VBL) and methotrexate (MTX) was evaluated in children and young adults with NF1 and PN. Patients ≤ 25...
Nowadays, a solvent-free method for production of high performance fibers directly from ultrahigh-molecular-weight polyethylene (UHMWPE) reactor powder is being actively developed. It causes the interest in the morphology of the reactor particles and...
In the present work, we provide a comprehensive numerical investigation of the magnetic properties and phase spectra of three types of spin-1/2 branched chains consisting of one, two and three side spins per unit block with intra-chain interaction an...
First-principles density functional theory was used to determine the surface band structures of CsPbBrxI3−x (x = 0, 1, 2, and 3) perovskites. The equilibrium lattice constants of CsPbBrxI3−x were obtained from the minimum of the total energy as a fun...
Infectious diarrhea caused by Shigella remains a significant global health concern, and several vaccine candidates are approaching phase III clinical studies in the target population of young children in low- and middle-income countries. The World He...
19 July 2021
The US and the rest of the world have suffered from the COVID-19 pandemic for over a year. The high transmissibility and severity of this virus have provoked governments to adopt a variety of mitigation strategies. Some of these previous measures, su...
The food-borne mycotoxin aflatoxin B1 (AFB1) poses a significant risk to poultry, which are highly susceptible to its hepatotoxic effects. Domesticated turkeys (Meleagris gallopavo) are especially sensitive, whereas wild turkeys (M. g. silvestris) ar...
This paper presents a Space Vector Modulation (SVM) method with a novel zero vector distribution system for electrical vehicle drives with a six-phase induction motor working under the Direct Field-Oriented Control (DFOC) method. Different SVM method...
In the context of the safe storage of high-level radioactive waste, the time-dependent retention of a waste cocktail (WC) consisting of Zr(IV), Mo(VI), Ru(III), Pd(II), Cs(I), Sm(III), Eu(III) and U(VI) was studied on the commercially available C-S-H...
Reconfigurable intelligent surfaces (RISs) can improve spectral efficiency (SE) and energy efficiency (EE) in cell-free massive multiple-input multiple-output (CF-mMIMO) networks by coherently controlling reflected propagation paths. Outdoor panels,...
Shape memory materials have been playing an important role in a wide range of bioengineering applications. At the same time, recent developments of graphene-based nanostructures, such as nanoribbons, have demonstrated that, due to the unique properti...
Vanadium dioxide (VO2) is a well-known phase-change material that exhibits a thermally driven insulator-to-metal transition (IMT) near 68 °C, leading to significant changes in its electrical and optical properties. This transition is governed by...
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