Advances in Age-Related Diseases: Molecular Mechanisms, Treatments, and Clinical Implications
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 46
Special Issue Editors
2. Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy
Interests: sarcopenia; nutrition; body composition; frailty; healthy aging; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals
2. Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy
Interests: geriatrics; sarcopenia; frailty; geriatric syndromes; geroscience; biomarkers; mitochondrial dysfunction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aging is a multifactorial biological process that drives increased susceptibility to chronic diseases, including neurodegenerative disorders, cardiometabolic disease, and musculoskeletal impairments. Advances in molecular biology, omics sciences, and translational medicine have uncovered key hallmarks of aging, such as genomic instability, mitochondrial dysfunction, cellular senescence, and dysregulated proteostasis. These discoveries provide crucial insights into the pathogenesis of age-related diseases and pave the way for innovative therapeutic approaches, including senolytics, stem cell therapies, and gene editing. However, while biomedical interventions hold promise, aging is influenced by a complex interplay of genetic, environmental, and lifestyle factors. Translating scientific advancements into impactful clinical and public health strategies presents a unique opportunity to develop targeted prevention and treatment approaches. Furthermore, a deeper exploration of how pharmacological and non-pharmacological interventions shape aging processes is essential for extending healthspan and improving quality of life.
We are pleased to invite you to contribute to this Special Issue, "Advances in Age-Related Diseases: Molecular Mechanisms, Treatments, and Clinical Implications", which aims to explore recent progress in the field, focusing on molecular pathways of aging, biomarkers for early disease detection, novel pharmacological and non-pharmacological interventions, and the clinical impact of emerging therapies.
We welcome original research articles and reviews on (but not limited to) the following themes:
- Cellular senescence and inflammation in aging;
- Oxidative stress and mitochondrial dysfunction;
- Genetic and epigenetic regulation of age-related diseases;
- Precision medicine and biomarkers for aging-related conditions;
- Pharmacological interventions and repurposing strategies;
- Translational and clinical research in geriatric medicine.
We look forward to receiving your contributions.
Dr. Stefano Cacciatore
Dr. Emanuele Marzetti
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aging
- age-related diseases
- cellular senescence
- mitochondrial dysfunction
- inflammation and oxidative stress
- biomarkers
- precision medicine
- pharmacological interventions
- healthy aging
- translational geriatric research
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