The advantage of using the Network Address Translation device is that the internal IP address, which makes the IP address space of Internet of Things (IoT) devices expanded, is invisible from the outside and safe from external attacks. However, the u...
The cell-surface targeting of neo-synthesized G protein-coupled receptors (GPCRs) involves the recruitment of receptors into COPII vesicles budding at endoplasmic reticulum exit sites (ERESs). This process is regulated for some GPCRs by escort protei...
7 December 2024
Improving teachers’ knowledge and skills in dealing with adolescent suicidality may be important for prevention. We evaluated the feasibility and acceptability of a theatre-based gatekeeper teacher training for adolescent suicide prevention (SP...
Introduction: Although several treatments for faecal incontinence are available, gas incontinence (GI) and soiling are difficult to manage. The aim of this study is to evaluate Gatekeeper™ for this subtype of faecal incontinence. Methods: Prosp...
Dutch farmers are turning to YouTube for insights into the nitrogen crisis. While the platform provides access to diverse information, its algorithmic structure—driven largely by economic interests—personalizes content delivery. This stud...
20 April 2022
The gatekeeper training of parents is a promising approach for suicide prevention in young people, but little research has addressed the effectiveness of such training, especially using online delivery. This study aimed to evaluate the efficacy and a...
Based on the traditional Chinese cultural belief of “male breadwinner, female homemaker”, as well as the systemic and interactive characteristics of families, this study aims to explore the relationship between maternal gatekeeping behavi...
The literature on ethnic groups that were formed following migration reveals how symbolic and socioeconomic boundaries are manipulated by veteran groups to keep out the unwanted immigrants. It shows how these boundaries are to maintain and preserve t...
In the digital content industry, the emerging multi-channel networks (MCNs) have dramatically changed the ways of content production and distribution in sustainable social media. As a result, it also brings an unprecedented impact and challenge to th...
6 December 2024
As early as 1978, the World Health Organization set primary healthcare as the basis on which health systems should be built worldwide. However, the health systems of the different countries show considerable variations in terms of the implementation...
26 June 2020
After the Fukushima Daiichi Nuclear Power Plant accident in March 2011, residents perceived a radiation exposure risk. To address the concerns about radiation exposure and the subsequent effects on their health, we developed the gatekeeper training p...
Teachers play a key role as gatekeepers in adolescent suicide prevention, and knowledge about suicidality is a well-established predictor of teachers’ gatekeeper self-efficacy. However, little attention has been paid to other potential predicto...
This study investigates people’s attitudes towards news media’s role as gatekeepers during the coronavirus pandemic. Specifically, this concerns news media’s quality control and the selection of the most important news about the pan...
Artificial intelligence (AI) is transforming how news is produced, curated, and consumed, challenging traditional gatekeeping theories rooted in human editorial control. We develop a robust theoretical framework to reconceptualize gatekeeping in the...
Transgender and gender-expansive (TGE) communities face persistent health inequities that are reproduced through everyday administrative and clinical encounters across care systems. A feedback-focused lens can clarify how those inequities are generat...
26 November 2022
Background: Plasmodium knowlesi malaria is a zoonotic infection that affects rural communities in South East Asia. Although the epidemiology of the disease has been extensively researched, the voices of individuals within affected communities often g...
This article explores the efficiency in the administration of social grants for adult persons with disabilities (PWDs) in the Northern Cape province of South Africa. The focus, in particular, is on explaining why, despite a gatekeeping element, adult...
According to Murray Bowen’s family systems theory, the family is an emotional unit where members influence each other. Family strength, in that members care for, respect, and communicate with each other sincerely and freely and overcome difficu...
This essay maps out a constellation of early modern English feminine gatekeeper tropes that represent female sexual consent and imagine a gendered Cartesian dualism. This trope’s inherent mind–body divide grants the female subject’s...
After the discovery of zinc deficiency in the 1960s, it soon became clear that zinc is essential for the function of the immune system. Zinc ions are involved in regulating intracellular signaling pathways in innate and adaptive immune cells. Zinc ho...
This review starts off with the first germline homozygous variants of the Nucleoporin 98 gene (NUP98) in siblings whose clinical presentation recalls Rothmund–Thomson (RTS) and Werner (WS) syndromes. The progeroid phenotype caused by a gene ass...
Geospatial Artificial Intelligence (GeoAI) enables the automated generation of built environment map features, such as building outlines/footprints, on a global scale. However, the integration of these AI-generated datasets into Volunteered Geographi...
Pressure ulcers are a major clinical problem in patients with severe immobility; however, their pathophysiology extends beyond mechanical pressure and localized ischemia. Repetitive ischemia–reperfusion promotes sustained reactive oxygen specie...
Mitochondria serve as central hubs for regulating numerous cellular processes that include metabolism, apoptosis, cell cycle progression, proliferation, differentiation, epigenetics, immune signaling, and aging. The voltage-dependent anion channel 1...
Pneumococcal vaccine development is driven by the achievement of high activity in a single gatekeeper assay: the bacterial opsonophagocytic killing (OPK) assay. New evidence challenges the dogma that anti-capsular antibodies have only a single functi...
Voice interfaces to anthropomorphic robotic arms are typically evaluated without a formal safety layer, or with safety as a post hoc filter trusting the transcript, leaving transcript corruption unaddressed. This paper presents the DAS3 Neuro-Voice C...
This review provided a comprehensive examination of various theories that attempt to explain hypnosis, focusing on the interplay between conscious and unconscious processes. We conducted a thorough analysis of key theories, from historical origins to...
How do social-media platforms such as TikTok function as a neutralising factor in the gatekeeping process in times of COVID-19 restrictions? How does TikTok change the experience culture in arts, and how does this impact how artists frame their worki...
Switch/sucrose non-fermentable (SWI/SNF)-related matrix-associated actin-dependent regulator of chromatin (SMARC) subfamily B member 1 (SMARCB1) is a core subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, one of the adenosine triphosph...
The strategy for treating bladder cancer (BC) depends on whether there is muscle invasion or not, with the latter mostly treated with intravesical therapy, such as with bacillus Calmette–Guérin (BCG). However, BCG treatment is unsuccessf...
Youth suicide risks have been on the rise or persistently elevated for decades, and Native American communities are especially vulnerable. This study provides a promising framework for suicide prevention among underserved populations in the U.S., esp...
RARγ is expressed during embryogenesis by stem/primitive progenitor cells, indicating a role in controlling their development. Supporting this view is that a physiological level of 10 nM of the RARγ agonist AGN205327 blocked stem/progenit...
Dyslipidemia in adolescents represents an early and potentially modifiable stage in the lifelong trajectory of cardiovascular disease. However, optimal lipid screening strategies in this age group remain controversial, particularly regarding feasibil...
The extracellular signal-regulated protein kinase 5 (ERK5) is a non-redundant mitogen-activated protein kinase (MAPK) that exhibits a unique C-terminal extension which comprises distinct structural and functional properties. Here, we sought to elucid...
Peroxiredoxins (PRDXs) constitute a class of thiol-dependent oxidoreductive regulatory factors whose functions extend beyond peroxide detoxification to include the regulation of oxidoreductive signaling, organelle homeostasis, and cell fate determina...
Transcatheter aortic valve implantation (TAVI) has become the predominant treatment strategy for severe aortic stenosis across all surgical risk categories. The coexistence of coronary artery disease (CAD) in 40–75% of TAVI candidates has tradi...
29 February 2012
Suicide is a major public health issue. In Japan, local governments are responsible for suicide prevention, and local government officers are therefore expected to act as gatekeepers for suicide prevention. In this study, through a questionnaire surv...
The aim of the study is to present the online processes related to religious phenomena appearing on digital platforms, primarily the practice of content filtering (gatekeeping, echo chamber, filter bubble), and a critical review of the scientific lit...
Digital gatekeeping is increasingly performed by adaptive systems that rank, sequence, package, moderate, and sometimes generate news across repeated interactions. This conceptual analysis asks two questions: how should researchers analyze these syst...
21 June 2021
Chest pain is a symptom that can be found in life-threatening conditions such as acute coronary syndrome (ACS). Those patients requiring invasive coronary angiography treatment or surgery should be identified. Often the clinical setting and laborator...
This study explores how institutional- and ideological-level pressures affect both the gatekeeping role and mental well-being of journalists reporting on traumatic incidents, particularly war, conflict, and crime in Pakistan. Using a qualitative rese...
Various phytosanitary treatments are used globally to ensure biosecurity for borders, whilst maintaining public health and safety in the consumption of fruits and vegetables. However, public health literacy of phytosanitary treatments is still low. F...
Background/Objectives: The EGFR T790M mutation drives lung cancer resistance by sterically hindering inhibitors and restoring ATP affinity. As C797S mutations render covalent inhibitors obsolete, novel non-covalent strategies are critical. This study...
Human protein kinase CK2 is an emerging target for neoplastic diseases. Potent lead structures for human CK2 inhibitors are derived from dibenzofuranones. Two new derivatives, 7,9-dichloro-1,2-dihydro-8-hydroxy-4-[(4-methoxyphenylamino)-methylene]dib...
Oligosaccharyltransferase (OST) is a multi-span membrane protein complex that catalyzes the addition of glycans to selected Asn residues within nascent polypeptides in the lumen of the endoplasmic reticulum. This process, termed N-glycosylation, is a...
Integrating pesticides and mineral elements into a multi-functional stimuli-responsive nanocarrier can have a synergistic effect on protecting plants from pesticides and the supply of nutrients. Herein, a pH dual-responsive multifunctional nanosystem...
Women without a partner can become single mothers by choice through the use of fertility treatments. In Belgium, the decision to accept a candidate single mother by choice rests with the fertility clinic’s multidisciplinary team of fertility practiti...
9 September 2020
This paper discusses the way that trans women embody their transgender identity, focusing on identity questioning, gender dysphoria, clinical gatekeeping and medicalized narratives. Situated within the hermeneutics methodological approach, we adopted...
Discussions of therapeutic suppression of hedgehog (Hh) signaling almost exclusively focus on receptor antagonism; however, hedgehog’s biosynthesis represents a unique and potentially targetable aspect of this oncogenic signaling pathway. Here, we re...
Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and...
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