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Nutritional Strategies in the Prevention and Treatment of Metabolic Syndrome...
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Nutritional Strategies in the Prevention and Treatment of Metabolic Syndrome (2nd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 1930

Special Issue Editors

Dr. Weicai Zeng

E-Mail Website
Guest Editor
Department of Food Engineering, Sichuan University, Chengdu 610065, China
Interests: food nutrition and health
Special Issues, Collections and Topics in MDPI journals
Dr. Tao Tong

E-Mail Website
Guest Editor
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Interests: functional foods; phytochemicals; chronic disease; skeletal muscle atrophy; photoaging; gut health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Based on the success of the first volume, we are launching the second edition of the Special Issue "Nutritional Strategies in the Prevention and Treatment of Metabolic Syndrome".

Metabolic syndrome, which is a cluster of comorbid conditions including obesity, hypertension, and disordered carbohydrate and lipid metabolism, constitutes a significant health and social problem around the world. Metabolic syndrome can lead to several serious and chronic complications, including type 2 diabetes, cardiovascular diseases, stroke, kidney disease, and nonalcoholic fatty liver disease. The most important risk factors are diet (particularly sugar-sweetened beverage consumption), genetics, aging, low physical activity, and excessive alcohol use. The management of metabolic syndrome is a complex and multifaceted process including drug therapy and lifestyle interventions. Evidence from various preclinical and clinical studies has revealed that various dietary components (nutrients, phytochemicals, prebiotics/probiotics, etc.) play a significant role in the prevention and treatment of metabolic syndrome and emerge as potential therapeutic agents in a broad range of metabolic syndrome models.

This research topic aims to provide the current contemporary knowledge of the effects of dietary components (nutrients, phytochemicals, prebiotics/probiotics, etc.) on metabolic syndrome, with the aim of offering new insights into potential preventive or therapeutic approaches for the clinical management of metabolic syndrome.

We warmly welcome review (systematic reviews and meta-analyses), original research articles, and clinical studies for this Special Issue.

Dr. Weicai Zeng
Dr. Tao Tong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary intervention
  • phytochemical
  • plant polyphenols
  • tea polyphenols
  • nutraceutical
  • prebiotics/probiotics
  • metabolic syndrome
  • high-fat diet
  • obesity
  • type 2 diabetes
  • diabetic nephropathy
  • diabetic cardiomyopathy
  • nonalcoholic steatohepatitis
  • skeletal muscle atrophy
  • sarcopenia

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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17 pages, 4441 KiB  
Article
Streptococcus salivarius subsp. thermophilus ST-G30 Prevents Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes
by Mengjie Li, Seong-Gook Kang, Kunlun Huang and Tao Tong
Nutrients 2025, 17(7), 1141; https://doi.org/10.3390/nu17071141 - 26 Mar 2025
Viewed by 388
Abstract
Background/Objectives: Sarcopenia is characterized by loss of muscle mass and strength and is associated with aging. Recently, its links with the gut–muscle axis have been reported, suggesting that probiotics could influence muscle health. Methods: In the present study, we investigated the protective roles [...] Read more.
Background/Objectives: Sarcopenia is characterized by loss of muscle mass and strength and is associated with aging. Recently, its links with the gut–muscle axis have been reported, suggesting that probiotics could influence muscle health. Methods: In the present study, we investigated the protective roles of two lactic acid bacteria strains, Streptococcus salivarius subsp. thermophilus ST-G30 (ST-G30) and Lacticaseibacillus paracasei LPc-G110 (LPc-G110), on skeletal muscle atrophy induced by dexamethasone (DEX) in C2C12 myotubes. Results: Our results demonstrated that ST-G30 significantly alleviated DEX-induced myotube atrophy by increasing the myotubes’ diameter (25.95 ± 1.28 vs. 15.30 ± 0.30 μm, p < 0.01), improving the fusion index (48.35 ± 1.75 vs. 22.16 ± 2.36%, p < 0.0001), and increasing the protein content (1.78 ± 0.02 vs. 1.56 ± 0.01 mg/mL, p < 0.05) and myotube length (0.61 ± 0.05 vs. 0.33 ± 0.01, p < 0.05), whereas LPc-G110 showed no significant effect on these phenotypes (p > 0.05). Transcriptomic analysis reveals that ST-G30 modulates critical signaling pathways and biological processes related to skeletal muscle health. In the current study, KEGG enrichment analysis and WGCNA enabled identification of the PI3K-Akt signaling pathway as a key regulator of these processes, highlighting its essential role in mitigating DEX-induced muscle atrophy. Furthermore, the overlapping DEGs associated with the PI3K-Akt signaling pathway showed strong correlations with muscle atrophy-related indices. Conclusions: These findings underscore the potential of ST-G30 as a promising anti-muscle atrophy supplement and provide valuable insights for developing strategies to prevent and treat glucocorticoid-induced skeletal muscle atrophy. Full article
(This article belongs to the Special Issue Nutritional Strategies in the Prevention and Treatment of Metabolic Syndrome (2nd Edition))
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Review

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18 pages, 678 KiB  
Review
Red Meat Amino Acids for Beginners: A Narrative Review
by Benjamin Barr, Danielle E. Levitt and Lauren Gollahon
Nutrients 2025, 17(6), 939; https://doi.org/10.3390/nu17060939 - 7 Mar 2025
Viewed by 1547
Abstract
Meat is a major source of dietary protein and fat across the globe. Red and white meat are the major terms consumers use to refer to types of meat; however, these terms do not fully encompass the range of nutrients provided by meat [...] Read more.
Meat is a major source of dietary protein and fat across the globe. Red and white meat are the major terms consumers use to refer to types of meat; however, these terms do not fully encompass the range of nutrients provided by meat sources. Red meat refers to meat from mammalian skeletal muscle, while white meat refers to poultry. Red and white meat both provide a wide range of nutritional components in the context of fatty acids, amino acids and micronutrients. Importantly, it has been demonstrated that amino acid profiles differ between red meat and white meat as well as between different sources of red meat. Red meat is a complete source of dietary amino acids, meaning it contains all essential amino acids (EAAs), and in addition, it contains all the non-essential amino acids (NEAAs). Red meat is also the most abundant source of bioavailable heme-iron essential for muscle growth and cardiovascular health. Red meat has been indicated as a major contributor to the rising incidence of metabolic disorders and even colorectal cancer. However, it is important to note that while red meat consumption is linked to these conditions, it is typically the overconsumption of red meat that is associated with obesity and other metabolic symptoms. Similarly, the preparation of red meat is a key factor in its link to colorectal cancer as some methods of preparation produce carcinogens while others do not. Finally, red meat may also be situationally more beneficial to some groups than others, particularly in the cases of sex and aging. For pregnant women, increases in red meat consumption may be beneficial to increase the intake of semi-essential amino acids, while in the elderly, increases in red meat consumption may better preserve muscle mass compared with other dietary protein sources. Full article
(This article belongs to the Special Issue Nutritional Strategies in the Prevention and Treatment of Metabolic Syndrome (2nd Edition))
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