G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 15 July 2024 | Viewed by 6250
Special Issue Editor
Interests: GPCR signaling; receptor phosphorylation; adrenergic receptors; signal transduction; phosphorylation; protein kinase C; adrenergic agents
Special Issue Information
Dear Colleagues,
G-protein-coupled receptors (GPCRs) are sensors of the external (light, odors, and tastants) and internal (hormones, neurotransmitters, and local hormones) milieux, mediating physiological functions and participating in the pathophysiology of many diseases. Therefore, GPCRs are targets of a large percentage of prescribed and illegal drugs. Pharmacology and therapeutics are advancing, leading to the discovery of full, partial, inverse, and biased agonists, antagonists, allosteric modulators, inducers of internalization and degradation, and the identification of unexpected actions of substances already employed in current medical practice, all of which has led to the development of targeted therapies for different maladies. Similarly, molecular strategies have allowed, at least partially, for the elucidation of how GPCR structure is modulated by different ligands and by proteins that regulate them through interaction and post-translational modifications, thus evidencing the formation of receptor complexes and their roles in signaling at the plasma membrane and endosomes. The current Special Issue welcomes submissions on these areas.
Prof. Dr. J. Adolfo García-Sáinz
Guest Editor
Manuscript Submission Information
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Keywords
- GPCR
- cell signaling
- small molecule drugs
- biased signaling
- endosomal signaling
- post-translational modification
- GPCR internalization
- phosphorylation barcode