Special Issue "Epigenetic Alterations in Age-Associated Diseases and Cancers"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2020).
Interests: epigenetics; DNA methylation in aging and cancer; environmental epigenetics; nanomedicine
The alterations of DNA methylation during aging, a process known as “epigenetic drift”, are well-documented. However, the alterations of other epigenetic marks such as the posttranslational histone modifications or the non-coding RNAs (ncRNAs) are not as well studied. Although the alterations of DNA methylation marks during aging are specific to each cell type, the histone marks associated with them appear to follow similar patterns in different tissues. That said, the association of these epigenetic alterations with functional changes are not yet well established.
Aging is a risk factor for many human diseases, including but not limited to neurological, cardiovascular, metabolic, and autoimmune conditions, as well as disorders such as infertility and even certain types of cancer. It is challenging to conduct in-depth study of the epigenetic alterations (i.e., DNA methylation, histone modifications, ncRNAs) associated specifically with human age-related diseases, and how internal factors (e.g., genotype) as well as external and stochastic factors are mediating these processes.
This Special Issue “Epigenetic Alterations in Age-Associated Diseases and Cancer” calls for original research and review articles that address current knowledge and progress being made in our understanding of the epigenetic alterations associated with age-related diseases, the possible functional effects that these alterations may trigger, and the role of the internal, external, and/or stochastic factors that may underlie these changes.
Prof. Dr. Agustin F. Fernandez
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- age-related diseases
- DNA methylation
- histone modifications
- epigenetic drift
- epigenetic clock