Background: Continuous oral targeted therapies (OTT) represent a major economic burden on the Canadian healthcare system, due to their high cost and administration until disease progression/toxicity. The recent introduction of venetoclax-based fixed-...
First-line options for chronic lymphocytic leukemia (CLL) are evolving, recently returning to a fixed-duration (FD) approach incorporating regimens such as venetoclax + obinutuzumab, ibrutinib + venetoclax, and soon acalabrutinib + venetoclax ±...
Background: Bruton tyrosine kinase inhibitors (BTKis) represent an advancement in chronic lymphocytic leukemia; however, these agents are administered continuously until disease progression or unacceptable toxicity, raising concerns about their affor...
A fixed duration of venetoclax-rituximab (VenR) resulted in a significant benefit of both PFS and in the attainment of an undetectable minimal residual disease (uMRD) compared with bendamustine-rituximab in relapsed/refractory (R/R) chronic lymphocyt...
25 April 2017
The focus of this article is on sleep duration and sleep problems in infants and their association with body weight. A retrospective birth cohort of 519 infants was enrolled in a community-based study conducted in Changsha, China. Infant weight and o...
Background and Objectives: When a single missing tooth must be replaced, the best solution is the placement of an implant. In adults, most of the time the space for implant is totally or partially closed due to the shift in the adjacent teeth. The ob...
Multiple myeloma (MM) presents unique challenges in the elderly population due to increased frailty and comorbidities. Balancing treatment efficacy, safety, and quality of life is essential in managing elderly patients. While two-drug regimens were o...
Backgrounds: Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of formalin-fixed paraffin-...
We examine a simple duration-rotation strategy applied to six U.S. Treasury ETFs spanning the full maturity spectrum, using data from 2007 to 2025. At each semi-annual rebalancing date, ETFs are ranked by prior-period return and divided into three eq...
Duration is a rarely investigated marker of exercise prescription. The aim of this study was to test the feasibility of the methodological approach, assessing effects of different duration constant-load exercise (CLE) on physiological responses (inte...
Over the past century, antibiotic usage has skyrocketed in the treatment of critically ill patients. There have been increasing calls to establish guidelines for appropriate treatment and durations of antibiosis. Antibiotic treatment, even when appro...
Introduction: The optimal freeze duration in cryoballoon pulmonary vein isolation (PVI) is unknown. TTI-based titration of cryoenergy allows individualized freeze duration and has emerged as a favorable ablation strategy in PV cryoablation. In a rece...
Background/Objectives: Teclistamab is a bispecific antibody targeting BCMA and CD3, approved for relapsed/refractory multiple myeloma. It is administered continuously until progression or intolerance; however, prolonged use may increase infections an...
This paper presents an analytical framework for the probability of spectrum hole utilization (PSHU) of a cognitive radio system with soft cooperative spectrum sensing (CSS) under a practical consideration of fixed frame structure. In practical system...
Most existing network sensor location problem (NSLP) models are designed to identify the number of sensors with fixed costs and installation locations, and sensors are assumed to be installed permanently. However, sometimes sensors are carried by ind...
Background and Objectives: Orthodontic treatment, whether fixed or removable, offers several benefits, including improved aesthetics, enhanced oral function, and increased self-confidence. However, it may also cause discomfort and pain, particularly...
Given the harsh working conditions of underwater pan-tilt systems, their energy consumption management is particularly crucial. This study proposes an underwater pan-tilt operation method with an automatic wake-up mechanism, which activates only upon...
The pantograph–catenary arc of urban rail has the characteristic of high temperature, which directly acts on the surface of the pantograph–catenary system, will seriously ablate pantograph and contact line, and affect the flow of the pant...
Molecular diagnostics in healthcare relies increasingly on genomic and transcriptomic methodologies and requires appropriate tissue specimens from which nucleic acids (NA) of sufficiently high quality can be obtained. Besides the duration of ischemia...
This paper delves into a multi-player non-renewable resource extraction differential game model, where the duration of the game is a random variable with a composite distribution function. We first explore the conditions under which the cooperative s...
26 April 2022
Although rotating shifts have a negative health impact, their association with hospital nurses’ health risks remains controversial due to incomplete adjustment in lifestyle patterns and heterogeneity of work schedules. However, whether work sch...
20 October 2026
Elaborate short-video design may support product-link clicking by providing richer information and more varied presentation; yet, it may also impose greater processing demands during recommendation-driven browsing. This study examines whether two vid...
The ability to stand up from a sitting position is essential for older adults to live independently. Body-fixed inertial sensors may provide an approach for quantifying the sit-to-stand (STS) in clinical settings. The aim of this study was to determi...
Background: Percussive massage therapy (PMT) with handheld massage guns is widely used to support recovery and flexibility, but the short-term behavior of skeletal muscle contractile properties and the relative contribution of application duration ve...
Premature and simultaneous buckling of several steel braces in steel structures due to the prolonged duration of a seismic motion is one of the issues that must be addressed in the next version of Eurocode 8. In an effort to contribute towards the im...
We study a resource leveling problem with variable job duration. The considered problem includes both scheduling and resource management decisions. The planning horizon is fixed and separated into a set of time periods of equal length. There are seve...
In this article, a model of the operation of a wireless sensor network (WSN) node with an energy saving mechanism based on a threshold-controlled multiple vacation policy is considered. When the queue of packets directed to the node becomes empty, a...
The performance of various nonlinear frequency division multiplexed (NFDM) fiber-optic transmission systems has been observed to decrease with increasing signal duration. For a class of NFDM systems known as b-modulators, we show that the nonlinear b...
Background: Prefecture-level mean elevation, as an area-level proxy of residential altitude, has been associated with sleep disturbance and depressive symptoms, but it may also reflect broader regional differences in social conditions. The roles of s...
The results of this research provide fixed-time fractional-order control for Euler–Lagrange systems that are subject to external disturbances. The first step in the process of developing a new system involves the introduction of a method known...
Surrogate endpoints are increasingly used in chronic lymphocytic leukemia (CLL) to accelerate treatment evaluation, but their validity is context-dependent. This review examines key endpoints—progression-free survival (PFS), time to next treatm...
Understanding the effect of horseshoe–surface combinations on hoof kinematics at gallop is relevant for optimising performance and minimising injury in racehorse–jockey dyads. This intervention study assessed hoof breakover duration in Thoroughbred e...
The aim of this paper is to present a stochastic model to generate sub-hourly rainfall events at a given point. Historical events used as the input have been extracted by the sub-hourly rainfall series available for a defined rain gauge station based...
Life-cycle assessment (LCA) is widely used to evaluate the environmental performance of polymer processing and mechanical recycling systems, with its reliability fundamentally dependent on the quality and representativeness of the underlying life-cyc...
Delays are a global issue affecting both airports and airlines. Departure delays are particularly likely to propagate across airports, rendering the entire flight network susceptible to increased delay durations. The delay network and its duration fl...
Current research trends in significant hydraulic engineering projects focus on investigating the seismological properties of intensity and frequency content of pulse-type near-field earthquakes on the structural response. Conversely, the duration imp...
Temporary employment is associated with an elevated risk of cardiovascular diseases and mortality. This study explored the association between temporary employment and dietary quality in middle-aged workers. This cross-sectional study included a nati...
Among several usages of unmanned aerial vehicles (UAV), wireless relay systems for high altitudes using fixed-wing UAVs, or high-altitude platform stations (HAPS), are some of the most promising applications. To realize the systems by making the most...
For geostationary orbit transfers, a long duration is required using electric propulsion and a large propellant mass is needed with chemical propulsion. Hybrid transfers can achieve a balance between the fuel consumption and transfer time. In this pa...
(1) Background: Patients with respiratory conditions typically exhibit adventitious respiratory sounds (ARS), such as wheezes and crackles. ARS events have variable duration. In this work we studied the influence of event duration on automatic ARS cl...
In the field of urban traffic management, optimizing traffic signals at intersections is crucial for enhancing traffic flow efficiency. Despite advances in intelligent traffic signal control strategies through deep reinforcement learning (DRL), pract...
Real-time quaking-induced conversion (RT-QuIC) assays have become a common tool to detect chronic wasting disease (CWD) and are very sensitive provided the assay duration is sufficient. However, a prolonged assay duration may lead to non-specific sig...
Transonic buffet flow is a classical complex and unstable flow that has a negative effect on aircraft fly safety. Therefore, it is crucial to study the unsteady characteristics of buffet flow. The numerical analysis method is very useful in achieving...
In this paper, the window-opening behavior in a three-star green building with an operation mark in Ningbo was investigated. Four single offices facing south were selected, and the measurement lasted 20–40 days in the cooling season. An analysi...
The primary processing of high-resolution precipitation records (5 min and shorter) is crucial for constructing dimensionless design hyetographs and identifying design-critical precipitation scenarios for urban drainage systems. A key step in this pr...
Background: Little is known about the influence of the duration of the kidney back-table preparation period and kidney temperature on graft outcomes after transplantation. The aim of this study is to investigate the back-table duration and its relati...
Construction contract durations are fixed during procurement, yet delivery often changes after risks materialize and formal extensions of time are approved. Although delays, extension-of-time claims, change orders, and risk-based duration estimation...
The limited battery capacity currently restricts the flight duration of unmanned aerial vehicles (UAVs). Additionally, tethered rotorcraft UAVs suffer from low efficiency, and deploying tethered balloons presents significant challenges. Consequently,...
(1) Aims: The main objective of this retrospective study was to assess the long-term stability of difficult orthodontic treatments treated to an excellent result and to correlate stability to possible prognostic factors. Secondary objectives were to...
In this paper, we attempt to determine the optimal duration of an anti-epidemic control strategy which targets susceptible people, under the isoperimetric condition that we could not control all individuals of this category due to restricted health r...
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