Hypertension usually coexists with diabetes mellitus and significantly increases the risk of macrovascular complications. Blood pressure measured at home, especially nocturnal blood pressure, is particularly important because it is more strongly asso...
Chrysin is a dietary flavonoid with antioxidant and anti-inflammatory activity, but its clinical potential is limited by poor oral bioavailability. This randomized double-blind three period crossover trial evaluated the pharmacokinetics of a novel mi...
Background/Objectives: Routine replacement of peripheral intravenous catheters (PIVCs) every 72–96 h remains common practice despite growing guideline support for clinically indicated replacement. Evidence from Asian healthcare settings remains...
The Westernized diet has been associated with the pathogenesis of metabolic diseases, whereas a Korean diet has been reported to exert beneficial effects on health in several studies. However, the effects of Western and Korean diets on the gut microb...
Comparative evidence across repeated botulinum toxin treatment cycles for hemifacial spasm (HFS) remains limited. This 50-week double-blind randomized crossover trial compared Abobotulinumtoxin A 100 U (Abo-BoNT-A) with Neubotulinumtoxin A 33.33 U (N...
Pain is a major contributor to disability in cervical dystonia (CD) and may persist despite improvement in abnormal head posture after botulinum toxin treatment. Whether increasing the dose of Neubotulinum toxin type A (Neu-BoNT-A) provides additiona...
Effective dental plaque control requires both toothbrushing and interdental cleaning; however, the optimal sequence of these procedures remains unclear, particularly when powered toothbrushes are used. This randomized, examiner-blinded, two-period cr...
Background/Objectives: Botanical nootropics are increasingly sought as natural alternatives to synthetic stimulants. Mangifera indica leaf extract, standardized to the polyphenol mangiferin, has shown promise in regulating brain activity and enhancin...
Background: Primary dysmenorrhea is a common gynecologic condition that frequently requires pharmacologic treatment. Pelubiprofen, a 2-arylpropionic acid-derived prodrug with relatively selective cyclooxygenase-2 inhibitory activity, has demonstrated...
Food intake data collected using subjective tools are prone to inaccuracies and biases. An objective assessment of food intake, such as metabolomic profiling, may offer a more accurate method if unique metabolites can be identified. To explore this o...
Adherence is a critical factor to consider when interpreting study results from randomized clinical trials (RCTs) comparing one diet to another, but it is frequently not reported by researchers. The purpose of this secondary analysis of the Keto–Med...
Probiotic efficacy may depend on reliable intestinal exposure, yet clinical evidence linking delivery engineering to measurable microbiome responses in humans remains limited. We compared two active doses of microencapsulated Lacticaseibacillus rhamn...
Background/Objectives: Mindfulness-based interventions show promise for reducing stress in people living with dementia, but rigorous evidence against active control conditions remains limited, and little is known about how to adapt mindfulness for th...
Background/Objectives: This study aimed to assess the acute effects of two isoenergetic but micronutrient-diverse meals—a Mediterranean-like meal (MdM) and a fast food-like meal (FFM)—on the autonomic nervous system (ANS), lung function,...
Background: The introduction of modern sub-perception modalities has improved the efficacy of spinal cord stimulation (SCS) in refractory pain syndromes of the trunk and lower limbs. The objective of this study was to evaluate the effectiveness of lo...
Increased oxidative stress and platelet apoptotic in middle-aged and elderly adults are important risk factors for atherosclerotic cardiovascular disease (ASCVD). Therefore, it is of great significance to control the oxidative stress and platelet apo...
Background: The optimal 13C-urea breath test (UBT) dosage for diagnosing Helicobacter pylori remains debated. We compared the accuracy and agreement of a low-dose 45 mg tablet (without citric acid) versus the standard 75 mg granule (with citric acid)...
Background: Chokeberries (Aronia spp.) are known to exhibit both direct and indirect antioxidant properties and have been associated with beneficial effects on human health, including cardiovascular risk factors (inflammation, serum lipids, sugars, b...
A prior study showed that rhythmic, but not arrhythmic, 12 Hz stimulation of the median nerve (MNS) entrained the sensorimotor cortex EEG signal and found that 10 Hz MNS improved tics in Tourette syndrome (TS). However, no control condition was teste...
28 October 2019
Background: This study aimed to compare the acute effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on glycemic control in middle-aged and older patients with type 2 diabetes (T2D), using treadmil...
Background/Objectives: Creatine monohydrate (CR) and L-arginine (LA) are widely used ergogenic supplements, but whether acute co-ingestion provides additional performance or task-specific cognitive benefits beyond either supplement alone remains unce...
Stoma bag filter-related issues, such as ballooning (the bag filling with gas), remain highly prevalent among users. The full-circle filter was purposely designed to reduce ballooning through the inclusion of a unique, full-circle pre-filter. Two sim...
The meta-analysis of plant sterol supplement studies suggests an 8% lowering of low density lipoprotein (LDL) cholesterol for 2 to 2.5 g/day of plant sterols. Cereal foods have been rarely tested, and one study showed a lower LDL lowering of 5.4% wit...
Background and Objectives: Foot wedges are widely used to modulate ankle alignment in clinical and athletic settings, yet the effects of mediolateral wedge placement on multi-planar lower limb biomechanics during functional unilateral exercises remai...
The aims of this study were to: (1) determine whether replacement of cow’s milk protein with soy resolves Chronic Functional Constipation (CFC); and (2) investigate the effects of cow’s milk β casein A1 and cow’s milk β casein A2 on CFC. Children dia...
Multivitamin/mineral (MVM) supplements are one of the most popular dietary supplement categories. The purpose of this analysis was to determine if a novel liposomal delivery mechanism improves mineral absorption from an MVM product. In a randomized c...
Objective: This single-blind randomized controlled crossover pilot trial investigated whether hard or soft knee orthotics affect the back in action (BIA) test battery performance. Methods: Twenty-four healthy participants (13 males, 11 females) were...
Background: Several single-arm prospective studies have demonstrated the safety and effectiveness of upper airway stimulation (UAS) for obstructive sleep apnea. There is limited evidence from randomized, controlled trials of the therapy benefit in te...
This study aimed to investigate the acute effects of the Kinesio tape (KT) application on functional performance in healthy athletes. In this randomized, controlled crossover trial, a total of sixteen healthy soccer players (male = 14; age = 23.28 &p...
This protocol aims to profile the pharmacokinetics of metformin and Andrographis paniculata (AP) and continue with untargeted pharmacometabolomics analysis on pre-dose and post-dose samples to characterise the metabolomics profiling associated with t...
The acupuncture point mapped into the body meridian line has been the subject of extensive research; however, the scientific basis of the body meridian line remains unknown. In the present study, a pair of line-magnets was attached along the heart me...
Background/Objectives: Halitosis is a condition characterized by an unpleasant malodor. Intra-oral halitosis is caused by volatile sulfur compounds (VSCs) and can be associated with oral dryness. Trehalose is one of the materials used to relieve oral...
2 May 2018
Background: The hypothesis of the central effect of carbohydrate mouth rinse (CMR) on performance improvement in a fed state has not been established, and its psychophysiological responses have not yet been described. The aim of this study was to eva...
While dietary fiber plays an important role in the health benefits associated with whole grain consumption, other ingredients concentrated in the outer bran layer, including alkylresorcinols, lignans, phenolic acids, phytosterols, and tocols, may als...
Background/Objectives: The Q-Collar™, a device that mildly compresses the jugular veins to increase cranial fluid volume, has been investigated for potential protection against brain changes associated with concussive and subconcussive impacts...
Plasma volume (PV) undergoes constant and dynamic changes, leading to a large intra-day variability in healthy individuals. Hydration is known to induce PV changes; however, the response to the intake of osmotically different fluids is still not full...
Protein intake has been reported to secrete insulin and lower glucose levels, but the effect of carbohydrate and protein co-ingestion on amino acid absorption has not been well documented. A randomized, placebo-controlled, single-blinded, crossover t...
Background/Objectives: Fruit juice is commonly consumed with meals, yet its liquid matrix and rapidly absorbable carbohydrates may influence postprandial glycemic excursions. Whether altering the timing of fruit juice intake relative to a meal can at...
Background and Objectives: Gait disorders represent one of the most disabling aspects in multiple sclerosis (MS) that strongly influence patient quality of life. The improvement of walking ability is a primary goal for rehabilitation treatment. The a...
Prader–Willi syndrome (PWS) is a rare genetic disorder characterized by a wide range of clinical manifestations, including obesity, hyperphagia, and behavioral problems. Bifidobacterium animalis subsp. lactis strain BPL1 has been shown to impro...
Crossover trials are specifically designed to evaluate treatment effects within individual participants through within-subject comparisons. In a standard AB/BA crossover trial, participants are randomly allocated to one of two treatment sequences: ei...
16 January 2016
Background: Eight weeks of a high protein diet (>3 g/kg/day) coupled with a periodized heavy resistance training program has been shown to positively affect body composition with no deleterious effects on health. Using a randomized, crossover desi...
Background/Objectives: Higher energy and carbohydrate intakes have been hypothesized to enhance resistance training adaptations, yet empirical evidence remains mixed. The purpose of this study was to investigate whether supplemental carbohydrate&ndas...
12 September 2017
Background: When combined with exercise, dietary amino acid (AA) supplementation is an effective method for accelerating fat mobilization. However, the effects of single AAs combined with exercise on fat oxidation remains unclear. We hypothesized tha...
Recent studies point out that not only the daily intake of energy and nutrients but the time of day when they are ingested notably regulates lipid metabolism and cardiovascular risk (CVR). Therefore, the aim of the study was to assess if the type of...
Background/Objectives: Central neuropathic pain (CNP) is difficult to manage, and comparative evidence for non-invasive brain stimulation is limited. We explored the short-term efficacy and safety of repetitive transcranial magnetic stimulation (rTMS...
Background/Objectives: We aimed to evaluate the efficacy and safety of a short-term dietary intervention using trigonelline-rich Sakurajima radish on vascular endothelial function in patients with metabolic syndrome (MetS). Methods: In this multicent...
The impact of caffeine and glucose supplementation in a hypoxic environment on endurance exercise performance remains inconclusive. The current study examined the effect of pre-exercise carbohydrate and caffeine supplementation on endurance exercise...
Pseudoxanthoma elasticum (PXE) is characterized by low levels of inorganic pyrophosphate (PPi) and a high activity of tissue-nonspecific alkaline phosphatase (TNAP). Lansoprazole is a partial inhibitor of TNAP. The aim was to investigate whether lans...
Background/Objectives: The consumption of SunGold kiwifruit, a fruit rich in vitamin C, has been associated with improved mood in healthy individuals with low vitamin C levels. However, no studies have examined this relationship in individuals with e...
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