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Preventive Care in Healthcare—2nd Edition
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Preventive Care in Healthcare—2nd Edition

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Preventive Medicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 5544

Special Issue Editor

Dr. Teruhide Koyama

E-Mail Website
Guest Editor
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan
Interests: epidemiology; cardiovascular disease; vascular biology; human behavior; endocrinology; metabolism; cancer; metastasis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Globally, the increase in healthy life expectancy has not kept pace with the increase in general life expectancy. It is no exaggeration to say that healthcare is changing rapidly with cultural evolution and social change. Therefore, the promotion of public health requires that we shape the conditions of daily life for each period in a person’s life, when they are born, grow up, work, live, and age, especially for chronic diseases.

Against this backdrop, this Special Issue has been launched to bring together research and review articles on various types of preventive care for NCDs (non-communicable diseases).

In this Special Issue, original research articles and reviewers are welcome. Research areas may include (but are not limited to) the following:

  • Lifestyle, including nutrients, sleep, physical activity, and physical inactivity;
  • Education;
  • Income and social protection;
  • Working life conditions;
  • Anti-aging;
  • Methodology for maintaining a healthy lifestyle.

Dr. Teruhide Koyama
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • preventive care
  • NCDs (non-communicable diseases)
  • healthy lifestyle
  • nutrients
  • sleep
  • physical activity
  • physical inactivity
  • education
  • income and social protection
  • working life conditions

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Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (4 papers)

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Research

10 pages, 1374 KiB  
Article
Effects of Trehalose on Halitosis: A Randomized Cross-Over Clinical Trial
by Hisataka Miyai, Takaaki Tomofuji, Hirofumi Mizuno, Manabu Morita, Momoko Nakahara, Kota Kataoka, Ichiro Sumita, Yurika Uchida, Naoki Toyama, Aya Yokoi, Reiko Yamanaka-Kohno, Noriko Takeuchi, Takayuki Maruyama and Daisuke Ekuni
Healthcare 2025, 13(6), 619; https://doi.org/10.3390/healthcare13060619 - 13 Mar 2025
Viewed by 558
Abstract
Background/Objectives: Halitosis is a condition characterized by an unpleasant malodor. Intra-oral halitosis is caused by volatile sulfur compounds (VSCs) and can be associated with oral dryness. Trehalose is one of the materials used to relieve oral dryness. The aim of the present study [...] Read more.
Background/Objectives: Halitosis is a condition characterized by an unpleasant malodor. Intra-oral halitosis is caused by volatile sulfur compounds (VSCs) and can be associated with oral dryness. Trehalose is one of the materials used to relieve oral dryness. The aim of the present study was to investigate the effect of trehalose on halitosis. Methods: This prospective, double-blinded, placebo-controlled, cross-over study enrolled volunteers from Okayama University Hospital. The participants were randomly divided into two groups, with one group receiving trehalose (a 10% trehalose solution) and the other receiving a placebo (distilled water) in a 1:1 allocation. The primary study outcome was the subjective organoleptic test. The secondary outcomes were the concentrations of the VSCs, which were measured using a portable gas chromatography device, and the oral moisture status, which was measured using an oral moisture meter. The planned sample size was 10 participants based on the previous study. Results: The final intention-to-treat analysis was performed using the data from 9 participants. After applying 10% trehalose as an oral spray, the organoleptic score decreased in a time-dependent manner. However, no significant differences were seen between the trehalose and placebo groups. In terms of secondary outcomes, the oral moisture levels increased immediately after the trehalose spray application, and significant differences in the amount of change from the baseline were seen between the trehalose and placebo groups (p = 0.047). No significant differences were seen in any of the other variables (p > 0.05). Conclusions: We could not identify any positive effects on halitosis from a one-time 10% trehalose application as an oral spray in this prospective, double-blinded, placebo-controlled, cross-over study. However, the trehalose application immediately improved the oral moisture levels and was useful for treating oral dryness. Full article
(This article belongs to the Special Issue Preventive Care in Healthcare—2nd Edition)
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10 pages, 1890 KiB  
Article
Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial
by Takayuki Maruyama, Eiji Takayama, Shinichi Tokuno, Manabu Morita and Daisuke Ekuni
Healthcare 2025, 13(5), 577; https://doi.org/10.3390/healthcare13050577 - 6 Mar 2025
Viewed by 695
Abstract
Background/Objectives: Initiation and progression of periodontal disease include oxidative stress. Systemic application of antioxidants may provide clinical benefits against periodontal disease including gingivitis. Recently, a jelly containing a high concentration of hydrogen (40 ppm) was developed. We hypothesized that oral intake of [...] Read more.
Background/Objectives: Initiation and progression of periodontal disease include oxidative stress. Systemic application of antioxidants may provide clinical benefits against periodontal disease including gingivitis. Recently, a jelly containing a high concentration of hydrogen (40 ppm) was developed. We hypothesized that oral intake of this hydrogen-rich jelly may be safe and effective on gingivitis. This clinical trial was designed to investigate the safety and efficacy of oral intake of hydrogen-rich jelly against gingival inflammation. Methods: Participants with gingivitis were instructed to orally ingest 30 g of hydrogen-rich jelly (experimental group) or placebo jelly (control group) three times a day for 14 consecutive days. The primary outcome of this trial was the percentage of bleeding on probing (BOP) sites. Secondary outcomes were oral parameters, serum reactive oxygen metabolites, antioxidant capacity, oxidative index, concentrations of cytokine (interleukin [IL]-1β, IL-6, IL-10, IL-17, and tumor necrosis factor-alpha) in gingival crevicular fluid, and adverse events. For all parameters, Mann–Whitney U test was used for comparison between experimental and control groups. Analysis of covariance, controlling for baseline periodontal inflamed surface area, was performed to evaluate the association between the effect of the hydrogen-rich jelly and gingival inflammation. Results: In the experiment and control groups, the percentage of sites with BOP and PISA significantly decreased at the end of the experiment compared to the baseline. However, no significant differences were found between groups (p > 0.05). Conclusions: Administration of hydrogen-rich jelly for 14 days decreased gingival inflammation. However, no significant differences were identified compared to the control group. Full article
(This article belongs to the Special Issue Preventive Care in Healthcare—2nd Edition)
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9 pages, 701 KiB  
Article
Effect of Antimicrobial Photodynamic Therapy on the Tongue Dorsum on Reducing Halitosis and the Duration of the Effect: A Randomized Clinical Trial
by Takayuki Maruyama, Daisuke Ekuni, Aya Yokoi, Junichiro Nagasaki, Nanami Sawada and Manabu Morita
Healthcare 2024, 12(10), 980; https://doi.org/10.3390/healthcare12100980 - 9 May 2024
Cited by 1 | Viewed by 1583
Abstract
Antimicrobial photodynamic therapy (PDT) is a treatment that is gaining popularity in modern clinical medicine. However, little is known about the effect of PDT alone on reducing oral halitosis and the duration of the effect. This trial examined the effect of PDT on [...] Read more.
Antimicrobial photodynamic therapy (PDT) is a treatment that is gaining popularity in modern clinical medicine. However, little is known about the effect of PDT alone on reducing oral halitosis and the duration of the effect. This trial examined the effect of PDT on the tongue dorsum on reducing oral halitosis and the duration of the effect. This study was approved by the Ethics Committee of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, and Okayama University Hospital (CRB20-015), and it was registered in the Japan Registry of Clinical Trials (jRCTs061200060). Twenty-two participants were randomly assigned to two groups: an intervention group and control group. PDT was performed in the intervention group using red laser emission and methylene blue gel on the middle and posterior area of the tongue dorsum. The concentration of volatile sulfur compounds, bacterial count on the tongue dorsum, probing pocket depth, bleeding on probing, and simplified oral debris index score were determined before and 1 week after PDT. The Mann–Whitney U test was used to assess the significance of the differences in each parameter between the two groups. We found that the hydrogen sulfide concentration and bacterial count on the tongue dorsum were decreased in the intervention group, but there was no statistically significant difference between the two groups. These results indicated that performing only PDT on the tongue dorsum may not contribute to reducing halitosis. Full article
(This article belongs to the Special Issue Preventive Care in Healthcare—2nd Edition)
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10 pages, 455 KiB  
Article
One Cup of Coffee a Day Modulates the Relationship between Metabolic Syndrome and Eating Fast: A Cross-Sectional Study
by Reisa Hiramatsu, Etsuko Ozaki, Satomi Tomida and Teruhide Koyama
Healthcare 2024, 12(6), 603; https://doi.org/10.3390/healthcare12060603 - 7 Mar 2024
Viewed by 2079
Abstract
Background: Eating speed has been implicated as a leading cause of metabolic syndrome (MetS). However, it is difficult to break the habit of eating fast. Since coffee consumption is associated with a lower risk of MetS, we investigated the association between eating speed [...] Read more.
Background: Eating speed has been implicated as a leading cause of metabolic syndrome (MetS). However, it is difficult to break the habit of eating fast. Since coffee consumption is associated with a lower risk of MetS, we investigated the association between eating speed and the amount of coffee consumed with MetS. Methods: This study included data from 3881 participants (2498 females and 1383 males). We used a self-administered questionnaire to collect information on participants’ coffee consumption (<1 cup/day and ≥1 cup/day) and eating speed (slow, normal, or fast). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression analyses to investigate the relationship between the prevalence of MetS due to eating speed and the amount of coffee consumed. Results: The group that consumed ≥1 cup/day of coffee (filtered or instant) had a lower OR for MetS compared to the group that consumed <1 cup/day (OR: 0.695; 95% Cl: 0.570–0.847). The eating fast group, compared to the eating slow group, had a higher OR for MetS (OR: 1.689; 95% Cl: 1.227–2.324). When the data were stratified by coffee consumption and eating speed groups, the slow-eating group among those who consumed <1 cup/day of coffee (filtered or instant) had a lower OR for MetS (OR: 0.502; 95% CI: 0.296–0.851) compared to the fast-eating group. In contrast, the groups who consumed ≥1 cup/day of coffee were associated with lower OR for MetS, regardless of their eating speed. Conclusions: This suggests that drinking ≥1 cup/day of coffee may help prevent MetS induced by eating fast. Full article
(This article belongs to the Special Issue Preventive Care in Healthcare—2nd Edition)
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