Continuous mRNA drugs manufacturing is perceived to nurture flow processes featuring quality by design, controlled automation, real time validation, robustness, and reproducibility, pertaining to regulatory harmonization. However, the actual adaptati...
In the evolving landscape of pharmaceutical manufacturing, a comprehensive continuous production process is being crafted for the small-scale production of active pharmaceutical ingredients. This study focuses on continuous crystallization with separ...
Progress in continuous flow chemistry over the past two decades has facilitated significant developments in the flow synthesis of a wide variety of Active Pharmaceutical Ingredients (APIs), the foundation of Continuous Pharmaceutical Manufacturing (C...
Continuous manufacturing (CM) is defined as a process in which the input material(s) are continuously fed into and transformed, and the processed output materials are continuously removed from the system. CM can be considered as matching the FDA’s so...
Integrated continuous manufacturing processes of active pharmaceutical ingredients (API) provide key benefits concerning product quality control, scale-up capability, and a reduced time-to-market. Thereby, the crystallization step, which is used in a...
Continuous fiber-reinforced material extrusion is an emerging additive manufacturing process that builds components layer by layer by extruding a continuous fiber-reinforced thermoplastic strand. This novel manufacturing process combines the benefits...
There have been considerable efforts on improving the lentiviral vector (LV) system and their production. However, there remains the persisting challenge of producing a sufficient quantity of LVs at manufacturing scale to support treatments beyond ea...
Many products from the fine chemicals and pharmaceuticals industries are currently manufactured batch-wise in multi-product plants. However, this processing scheme suffers from severe drawbacks, such as a high specific energy demand, cleaning costs a...
Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents...
Continuous fiber-reinforced manufacturing has many advantages, but the fabrication cost is high and its process is difficult to control. This paper presents a method for printing fiber-reinforced composite on the common fused filament fabrication (FF...
Continuous carbon fibre-reinforced thermoplastic composites have convincing anisotropic properties, which can be used to strengthen structural components in a local, variable and efficient way. In this study, an additive manufacturing (AM) process is...
Electronic devices are sensitive to electromagnetic (EM) emissions, and require electromagnetic shielding protection to ensure good operation, and prevent noise, malfunctioning, or even burning. To ensure protection, it is important to develop suitab...
Continuous improvement (CI) is vital for Saudi manufacturing firms to remain competitive in the global market. However, cultural factors significantly influence CI adoption. This qualitative study, involving 28 interviews and focus groups with employ...
In the current process for additive manufacturing of continuous carbon fiber reinforced resin matrix composites, the fiber and resin matrix are fed into the molten chamber, and then impregnated and compounded in the original position, and finally ext...
The biopharmaceutical industry is undergoing a fundamental transformation from traditional batch manufacturing to continuous manufacturing (CM) for recombinant drugs and biosimilars, driven by regulatory support through the International Council for...
As the pharmaceutical industry seeks more efficient methods for the production of higher value therapeutics, the associated data analysis, data visualization, and predictive modeling require dependable data origination, management, transfer, and inte...
The administration of viral vectored vaccines remains one of the most effective ways to respond to the ongoing novel coronavirus disease 2019 (COVID-19) pandemic. However, pre-existing immunity to the viral vector hinders its potency, resulting in a...
Manufacturing processes for monofunctional and multifunctional materials vary depending on the design optimization. Multifunctional continuous carbon fiber composites provide great potential in achieving coupled structural and electrical properties f...
The process of the additive manufacturing (AM) of carbon-fiber-reinforced polymer (CFRP) parts based on the process of fused deposition modeling (FDM) has seen considerable research in recent years, which amplifies the importance of adapted slicing a...
Using cocrystals has emerged as a promising strategy to improve the physicochemical properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase from two or more components. Particle size and morphology control are key qu...
Currently, because of global competition, companies within the manufacturing industry must implement new organizational and production techniques to compete and stay active. The use of continuous improvement tools has become an opportunity and an eff...
In view of growing interest and investment in continuous manufacturing, the development and utilization of mathematical model(s) of the manufacturing line is of prime importance. These models are essential for understanding the complex interplay betw...
Energy and failure are separately managed in scheduling problems despite the commonalities between these optimization problems. In this paper, an energy- and failure-aware continuous production scheduling problem (EFACPS) at the unit process level is...
Therapeutic proteins treat many acute and chronic diseases that were until recently considered untreatable. However, their high development cost keeps them out of reach of most patients around the world. One plausible solution to lower-cost manufactu...
Continuous manufacturing opens up new operation windows with improved product quality in contrast to documented lot deviations in batch or fed-batch operations. A more sophisticated process control strategy is needed to adjust operation parameters an...
Residence-time-distribution (RTD)-based models are key to understanding the mixing dynamics of continuous manufacturing systems. Such models can allow for material traceability throughout the process and can provide the ability for removal of non-con...
3D printing is an emerging and disruptive technology, supporting the field of medicine over the past decades. In the recent years, the use of additive manufacturing (AM) has had a strong impact on everyday dental applications. Despite remarkable prev...
Objectives: Hot-melt extrusion (HME) offers a solvent-free, scalable approach for manufacturing pharmaceutical co-crystals (CCs), aligning with the industry’s shift to continuous manufacturing (CM). However, challenges like undefined yield opti...
Continuous manufacturing is becoming the new technological standard in the pharmaceutical industry. In this work, a twin-screw processor was employed for the continuous production of liquisolid tablets containing either simethicone or a combination o...
Additive manufacturing (AM) has arisen as a transformative technology for manufacturing complex geometries with enhanced mechanical properties, particularly in the realm of continuous fiber-reinforced polymer composites (CFRPCs). Among various AM tec...
Continuous fiber-reinforced polymer (CoFRP) parts offer significant potential for reducing future product consumption and CO2 emissions due to their high tensile properties and low density. Additive manufacturing enables the tool-free production of c...
This study proposes a reliable inline PAT concept for the simultaneous monitoring of different product components after chromatography. The feed for purification consisted of four main components, IgG monomer, dimer, and two lower molecular weight co...
5-Fluorouracil (5-FU), a BCS class III drug, has low oral bioavailability and is cytotoxic in nature causing severe systemic side effects when administered through the intravenous route. Topical drug delivery could potentially mitigate the systemic s...
Pharmaceutical secondary manufacturing has long stood in stark contrast to the drug discovery end of the business, as well as to other sectors, when it comes to innovation such as continuous manufacturing. [...]
Three-dimensional (3D) printing with continuous carbon-fiber-reinforced polymer (C-CFRP) composites is under increasing development, as it offers more versatility than traditional molding processes, such as the out-of-autoclave-vacuum bag only (OOA-V...
This study explores the flexural behavior of continuous fiber-reinforced composite sandwich structures built entirely using material extrusion additive manufacturing. The continuous fiber additive manufacturing system used in this study works sequent...
Topology Optimization (TO) recently gained importance due to the development of Additive Manufacturing (AM) processes that produce components with good mechanical properties. Among all additive manufacturing technologies, continuous fiber fused filam...
Additive manufacturing (AM) is a rapidly growing technology, referring to a 3D design process by which digital data builds a physical object in layers by depositing the printed material. The AM has evolved in the aviation, automotive, and medical ind...
In this study, an AM-based continuous processing reactor system was designed, manufactured, and assembled on a laboratory scale for the generation of pharmaceutical substances with an improved process control. The developed AM-based (additively manuf...
In this study, the influence of curvilinear fibre reinforcement on the load-carrying capacity of additively manufactured continuous carbon fibre reinforced necked double shear lugs was investigated. A curvilinear fibre placement is descriptive of lay...
This study investigates the machinability of Continuous Fiber-Reinforced Thermoplastic Composite (CFRTP) produced via Material Extrusion (MEX) additive manufacturing, focusing on drilling as a critical post-processing step in hybrid manufacturing. CF...
The objective of this study is to show the applicability of various 3D-printed composite curved beams using continuous fibers and their delamination strength when they are subjected to bending loading. Four-point bending tests are configured for comp...
Additively manufactured polymer structures often exhibit strong anisotropies due to their layered composition. Although existing methods in additive manufacturing (AM) for improving the mechanical properties are available, they usually do not elimina...
Continuous processing offers many advantages in pharmaceutical manufacturing. [...]
Silver nanowires (AgNWs) have garnered significant attention in nanotechnology due to their unique mechanical and electrical properties and versatile applications. This review explores the synthesis of AgNWs, with a specific focus on the utilization...
Large Area Additive Manufacturing (LAAM) enables the rapid production of thermoplastic polymer structures but suffers from significant anisotropy and 3D printability limitations. These limitations often require additional material and time in order t...
Additively manufactured continuous fibre-reinforced polymers (CFRPs) offer promising mechanical properties for engineering applications, including aerospace and automotive load-bearing structures. However, challenges such as weak interlayer bonding a...
Despite an emerging interest in soft and rigid pneumatic lightweight robots, the pneumatic rotary actuators available to date either are unsuitable for servo pneumatic applications or provide a limited angular range. This study describes the function...
Additive manufacturing (or 3D printing) of continuous carbon fiber-reinforced plastics with fused deposition modeling is a burgeoning manufacturing method because of its potential as a powerful approach to produce lightweight, high strength and compl...
The pharmaceutical industry has witnessed exponential growth in transforming operations towards continuous manufacturing to increase profitability, reduce waste and extend product ranges. Model predictive control (MPC) can be applied to enable this v...
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