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Pharmaceutics
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Dosage Forms in Drug Delivery: State of the Art and...
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Dosage Forms in Drug Delivery: State of the Art and Future Perspectives, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 2521

Special Issue Editor

Dr. Cristina Martín-Sabroso

E-Mail Website
Guest Editor
Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
Interests: nanomedicine; cancer; controlled release systems; prosthetic infection; microparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The design and optimization of dosage forms play a pivotal role in drug delivery. These dosage forms are very varied, including oral dosage forms (e.g., tablets or capsules), injectable dosage forms (e.g., microparticles, implants, nanoparticles, or liposomes), and topical dosage forms (e.g., patches). These formulations have a significant impact on absorption, distribution, and patient compliance. This Special Issue, entitled "Dosage Forms in Drug Delivery: State of the Art and Future Perspectives, 2nd Edition", aims to provide an in-depth examination of the latest advancements and emerging trends in dosage form design and their implications for drug delivery. It will cover a wide range of topics, including novel formulation approaches, biopharmaceutical considerations, and the use of advanced materials and technologies to enhance drug release, stability, and targeting. The purpose of this Special Issue is to present cutting-edge research and innovations in dosage form design and development, highlighting both current practices and future trends. By bringing together leading experts and emerging voices in the field, this Special Issue aims to foster advancements in formulation science and enhance the precision and effectiveness of drug delivery systems.

We look forward to receiving your contributions. 

Dr. Cristina Martín-Sabroso
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dosage forms
  • drug delivery
  • tablets
  • capsules
  • nanoparticles
  • liposomes
  • patches
  • microparticles
  • implants
  • therapeutic efficacy

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Related Special Issue

Published Papers (2 papers)

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Research

13 pages, 3526 KB  
Article
A Randomized, Open, Single-Administration, Cross-Over Study to Investigate the Acceptability, Swallowability, Palatability, and Preference of Different Oral Placebo Formulations in Patients with Multiple Sclerosis
by Hans Martin Bosse, Kotryna Karosaite, Carolin Kloft, Melanie Schütte, Marc Pawlitzki, Philipp Albrecht, Sharmishtha Chauhan, Isabelle Gallou, Sebastien Chabaud, Tushar Sawai, Haripriya Tumuluri, Manfred Wargenau, Lucas-Sebastian Spitzhorn and Viviane Klingmann
Pharmaceutics 2026, 18(3), 353; https://doi.org/10.3390/pharmaceutics18030353 - 12 Mar 2026
Viewed by 585
Abstract
Background: There is a paucity of systematic investigations of the acceptability and preference of alternative oral drug formulations in multiple sclerosis (MS) patients. The use of appropriate oral dosage forms has the potential to circumvent challenges associated with the ingestion of tablets. Objective: [...] Read more.
Background: There is a paucity of systematic investigations of the acceptability and preference of alternative oral drug formulations in multiple sclerosis (MS) patients. The use of appropriate oral dosage forms has the potential to circumvent challenges associated with the ingestion of tablets. Objective: This randomized, open, cross-over study aimed to investigate acceptability, swallowability, palatability, and preference of four oral placebo drug formulations of similar sizes/given volumes but different modes of ingestion (film-coated tablet, orodispersible tablet, orodispersible film, and gel) in MS patients. Methods: Acceptability was tested in two patient subgroups (32 participants each) of different MS disability levels (expanded disability status scale [EDSS] < 4 and ≥4). The primary endpoint was acceptability derived as a composite of swallowability (rated by investigator) and palatability (rated by participant). Results: The film-coated tablet showed the highest acceptability rates for EDSS < 4 and EDSS ≥ 4 (100.0%, 93.8%), followed by gel (81.3%, 68.8%). Acceptability rates for all formulations were consistently higher for EDSS < 4 compared to EDSS ≥ 4. Concerning the subjective assessment of palatability, the gel received the highest rate of positive ratings, but also was frequently judged as ‘Unpleasant’. Furthermore, the gel was ranked as the first or second choice as the most-preferred formulation, followed by the film-coated tablet. All formulations were considered safe in the study population. Conclusions: Film-coated tablets are well-suited for use in MS patients and gels may represent an interesting alternative for a certain subgroup of MS patients. Full article
(This article belongs to the Special Issue Dosage Forms in Drug Delivery: State of the Art and Future Perspectives, 2nd Edition)
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32 pages, 28958 KB  
Article
Laser-Based QR Code Marking on Double Film-Coated Tablets: Balancing Marking Efficiency and Tablet Integrity—A Step Toward Safer Medicines
by Hadi Shammout, Béla Hopp, Tamás Smausz, János Bohus, Orsolya Jójárt-Laczkovich, Martin Cseh, Judit Kopniczky, Balázs Tari, Ranim Saker, Katalin Kristó, Tamás Sovány and Krisztina Ludasi
Pharmaceutics 2026, 18(1), 73; https://doi.org/10.3390/pharmaceutics18010073 - 6 Jan 2026
Cited by 1 | Viewed by 1593
Abstract
Background/Objectives: Laser has a prominent place in pharmaceutical industry, especially in the marking of solid dosage forms (SDFs). To combat falsified medicines, this study evaluates QR code marking on the surface of tablets as a supplement to serialization on packaging, using an [...] Read more.
Background/Objectives: Laser has a prominent place in pharmaceutical industry, especially in the marking of solid dosage forms (SDFs). To combat falsified medicines, this study evaluates QR code marking on the surface of tablets as a supplement to serialization on packaging, using an ultrafast laser to achieve industrially relevant marking speeds while preserving the functional integrity of double film-coated ibuprofen tablets. Methods: Tablets were directly compressed and coated with a double film: the inner layer was a gastro-resistant coating (Acryl-EZE® MP), while the outer one was a coloured, TiO2-containing (TC) or TiO2-free (TF) immediate-release coating (Opadry®). QR codes were ablated on the tablet surface using various laser parameters (e.g., pulse energy and scanning speed), and the effects were physically, chemically, and microscopically examined to evaluate their properties after this processing. Results: No significant differences were observed between TC and TF coatings. In addition, the readability of QR code is strongly influenced by laser settings and coating types. Furthermore, the used laser has achieved the expected fast marking speed and high-precision coding, which may be economically feasible for pharmaceutical companies. According to the profilometry findings, the ablation depth could be compensated for with an appropriate coating thickness to enable the desired release properties. This was confirmed by the results of SEM, Raman analysis, and in vitro dissolution test. Conclusions: Ultrafast Ti:Sa laser-based QR code marking directly onto the dosage form offers increasing benefits in the healthcare field. However, it may undesirably affect the behavior of the dosage form. This requires careful consideration of formulation and laser processing conditions before application, especially in the case of delayed-release (DR) systems. Full article
(This article belongs to the Special Issue Dosage Forms in Drug Delivery: State of the Art and Future Perspectives, 2nd Edition)
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