A Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line
AbstractAs the pharmaceutical industry seeks more efficient methods for the production of higher value therapeutics, the associated data analysis, data visualization, and predictive modeling require dependable data origination, management, transfer, and integration. As a result, the management and integration of data in a consistent, organized, and reliable manner is a big challenge for the pharmaceutical industry. In this work, an ontological information infrastructure is developed to integrate data within manufacturing plants and analytical laboratories. The ANSI/ISA-88.01 batch control standard has been adapted in this study to deliver a well-defined data structure that will improve the data communication inside the system architecture for continuous processing. All the detailed information of the lab-based experiment and process manufacturing, including equipment, samples and parameters, are documented in the recipe. This recipe model is implemented into a process control system (PCS), data historian, as well as Electronic Laboratory Notebook (ELN) system. Data existing in the recipe can be eventually exported from this system to cloud storage, which could provide a reliable and consistent data source for data visualization, data analysis, or process modeling. View Full-Text
A printed edition of this Special Issue is available here.
Share & Cite This Article
Cao, H.; Mushnoori, S.; Higgins, B.; Kollipara, C.; Fermier, A.; Hausner, D.; Jha, S.; Singh, R.; Ierapetritou, M.; Ramachandran, R. A Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line. Processes 2018, 6, 53.
Cao H, Mushnoori S, Higgins B, Kollipara C, Fermier A, Hausner D, Jha S, Singh R, Ierapetritou M, Ramachandran R. A Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line. Processes. 2018; 6(5):53.Chicago/Turabian Style
Cao, Huiyi; Mushnoori, Srinivas; Higgins, Barry; Kollipara, Chandrasekhar; Fermier, Adam; Hausner, Douglas; Jha, Shantenu; Singh, Ravendra; Ierapetritou, Marianthi; Ramachandran, Rohit. 2018. "A Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line." Processes 6, no. 5: 53.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.