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Open AccessFeature PaperReview

Spray Freeze-Drying as a Solution to Continuous Manufacturing of Pharmaceutical Products in Bulk

Molecular Engineering Laboratory, Department of Applied Science and Technology, Politecnico di Torino, 24 Corso Duca degli Abruzzi, 10129 Torino, Italy
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Processes 2020, 8(6), 709; https://doi.org/10.3390/pr8060709
Received: 13 May 2020 / Revised: 11 June 2020 / Accepted: 15 June 2020 / Published: 19 June 2020
(This article belongs to the Special Issue Modern Freeze Drying Design for More Efficient Processes)
Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing and hence of lyophilization as a downstream operation. In this direction, the present review deals with the most recent technologies, based on spray freeze-drying, that can achieve this objective. It provides a comprehensive overview of the physics behind this process and of the most recent equipment design. View Full-Text
Keywords: spray freeze-drying; freezing; atomization; pharmaceuticals; continuous manufacturing spray freeze-drying; freezing; atomization; pharmaceuticals; continuous manufacturing
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MDPI and ACS Style

Adali, M.B.; Barresi, A.A.; Boccardo, G.; Pisano, R. Spray Freeze-Drying as a Solution to Continuous Manufacturing of Pharmaceutical Products in Bulk. Processes 2020, 8, 709.

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