Modern biotechnology has rapidly developed, and biotechnological drugs have become the center of global drug research and development as an important aspect of clinical treatment. These drugs have unique advantages, such as strong species specificity...
This work aims to analyze theoretically and with laboratory tests the sensitivity of high-frequency GPR (Ground-Penetrating Radar) to resin injections used in the building and ornamental stone industries to repair marble blocks before final slab cutt...
Control strategy and quality by design (QbD) are widely used to develop pharmaceutical products and improve drug quality; however, studies on fixed-dose combination (FDC) bilayer tablets are limited. In this study, the bilayer tablet consisted of hig...
Artificial intelligence is reshaping RNA research by enabling predictive, data-driven workflows across molecular design, therapeutic development, delivery optimization, and analytical quality control. RNA-based medicines, including messenger RNA vacc...
The demand for reliable, rapid, and low-cost tools for quality control analysis has driven the development and application of different instrumental approaches in the wine industry. Thus, this review aims to gather and discuss the most relevant analy...
Nutraceuticals are food-based products that provide health benefits beyond basic nutrition and play an increasingly important role in preventive healthcare. Ensuring their quality, safety, and efficacy is critical as the global market expands. A syst...
Collagen is a popular nutricosmetic ingredient in food supplements due to its anti-aging and other positive effects on the skin. Due to its widespread use and the lack of regulation in this area, appropriate quality control is required to ensure effi...
Flavonoids, a ubiquitous class of plant secondary metabolites, are increasingly pivotal as chemical markers for ensuring the quality, safety, and efficacy of herbal medicines (HMs). Their broad distribution, biological activities, and detectability m...
Cosmetics analysis represents a rapidly expanding field of analytical chemistry as new cosmetic formulations are increasingly in demand on the market and the ingredients required for their production are constantly evolving. Each country applies stri...
Food quality control is an important area to address, as it directly impacts the health of the whole population. To evaluate the food authenticity and quality, the organoleptic feature of the food aroma is very important, such that the composition of...
In recent years, food authentication has acquired significant importance due to the increase in the incidence of fraud and counterfeiting. Alcoholic beverages are among the food products most susceptible to these kinds of illicit practices due to the...
Quality control is central to the safety and consistency of traditional Chinese medicine (TCM), yet the chemical complexity of herbal materials complicates the interpretation of single-marker tests. Machine learning can extract patterns from high-dim...
Rheum tanguticum (Maxim. ex Regel) Balf. is one of three botanical sources of Dahuang and exhibits chemical and processing variability that complicates species attribution and quality assessment. This review aims to synthesize species-specific phytoc...
The increasing demand for multi-ingredient dietary supplements (MIDS), driven by diverse consumer health needs, has introduced analytical challenges in product testing and quality control. These challenges stem from complex ingredient interactions, f...
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that...
Antibody–drug conjugates (ADCs) are a pivotal technology for precision cancer therapy, harnessing the synergistic effects of antibody targeting and toxin delivery. However, traditional ADCs encounter limitations in efficacy that stem from tumor...
Timely centrifugation of blood for plasma preparation is a key step to ensure high plasma quality for analytics. Delays during preparation can significantly influence readouts of key clinical parameters. However, in a routine clinical environment, a...
Background: Internal quality control (IQC) data offers continuous insight into analytical performance under routine conditions. This study evaluated IQC practices and long-term analytical imprecision (CVa) across primary healthcare laboratories to de...
Lyophilization is a widely used preservation method for thermosensitive products. It consists of three process steps: freezing, primary and secondary drying. One of the major drawbacks is the long processing time. The main optimization effort was put...
Lyophilization is a widely used drying operation, but long processing times are a major drawback. Most lyophilization processes are conducted by a recipe that is not changed or optimized after implementation. With the regulatory demanded quality by d...
A novel gas chromatography method was developed using automatic injections to identify and quantify the amount of residual solvents or analytes in samples of fluorine-18 and carbon-11 radiopharmaceuticals. This approach evaluates seven analytes in le...
Ensuring high levels of quality and efficiency is essential for compliance with ISO standards in chemical manufacturing. Traditional methods, such as Statistical Process Control (SPC) and Six Sigma, often lack adaptability and fail to offer interpret...
Digital twins have emerged as a powerful concept for real-time monitoring and analysis, facilitating Quality by Design integration into biopharmaceutical manufacturing. Traditionally, lyophilization processes are developed through trial-and-error, in...
The transition from Industry 4.0 to Industry 5.0 gives more prominence to human-centered and sustainable manufacturing practices. This paper proposes a conceptual design framework based on Vision Transformers (ViTs) and digital twins, to meet the dem...
Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs of...
A simple analytical approach based on capillary zone electrophoresis with ultraviolet detection and repeated sample injection strategy (applied in a hydrodynamically closed separation system for the first time) was developed for the determination of...
The rapid expansion of RNA therapeutics requires analytical methods that resolve molecular integrity, heterogeneity, and process-related impurities. Capillary electrophoresis (CE) provides direct RNA separation with low sample consumption and can be...
Background and Objectives: Point of care test (POCT) is generally performed by non-laboratory staff who often lack an understanding on the quality control and quality assurance programs. The purpose of this study was to understand the current status...
Determining reducing sugars in honey is key to ensuring its quality and authenticity. Honey mainly contains fructose and glucose, which represent around 90–95% of the total sugar content, and is one of the most adulterated foodstuffs worldwide....
Synthetic amorphous silica (SAS), manufactured in pyrogenic or precipitated form, is a nanomaterial with a widespread use as food additive (E 551). Oral exposure to SAS results from its use in food and dietary supplements, pharmaceuticals and toothpa...
Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes. It has attracted more and more interest nowadays due to its high efficiency, robustness, and a...
The development and adoption of digital twins (DT) for Quality-by-Design (QbD)-based processes with flexible operating points within a proven acceptable range (PAR) and automation through Advanced Process Control (APC) with Process Analytical Technol...
In addition to the nutritional and therapeutic benefits, Argan oil is praised for its unique bio-ecological and botanic interest. It has been used for centuries to treat cardiovascular issues, diabetes, and skin infections, as well as for its anti-in...
6 March 2021
Background: An infectious disease can affect human beings at an alarming speed in modern society, where Coronavirus Disease 2019 (COVID-19) has led to a worldwide pandemic, posing grave threats to public security and the social economies. However, as...
Centella asiatica (C. asiatica) has attracted significant scientific interest due to its extensive medicinal properties and long-established use in traditional medicine. This review synthesizes recent advances in the technological exploitation of C. ...
Background/Objectives: Aucklandia costus (Mu Xiang) is a widely used herbal product whose vernacular name is also applied to Aristolochia species. Aristolochia contains nephrotoxic and carcinogenic aristolochic acids, and misidentification can t...
Quality-by-Design (QbD) is demanded by regulatory authorities in biopharmaceutical production. Within the QbD frame advanced process control (APC), facilitated through process analytical technology (PAT) and digital twins (DT), plays an increasingly...
Chromatographic fingerprint technology has become the standard of quality control for traditional herbal medicines (THMs). But several issues are associated with the wavelength selection of the representative fingerprint, such as contradictory evalua...
A key technological challenge for automotive manufacturers is producing multiple vehicle variants on a single production line. At the body-in-white shop of Magna’s complete vehicle plant in Graz, this is addressed through transportable position...
Background/Objectives: The N-NOSE test is a non-invasive, urine-based multi-cancer screening assay that uses Caenorhabditis elegans chemotaxis toward cancer-associated volatile organic compounds in human urine. Scaling the test from a manual research...
As the aging population increases, elderly drivers face challenges due to physical and cognitive decline, in addition to the growing complexity of in-car technology and interaction features. This study aims to optimize the in-car control interface fo...
A potentiometric electronic tongue (ET) for the analysis of well and ditch irrigation water samples is herein proposed. The sensors’ array is composed of six ion-selective electrodes based on plasticized polymeric membranes with low selectivity...
Plant-based dietary supplements are regulated as food and made from raw materials of variable composition, so their quality control requires reliable analytical processes. A procedure for the determination of calcium and iron by high-resolution conti...
Polyscias fruticosa (L.) Harms is consumed as food and used traditionally in Southeast Asia, but reproducible ingredient development requires the alignment of raw material identity, chemical specification, processing, exposure, safety, and claims. Th...
Background: The present work represents a feasibility study for the realization of an analytical method finalized to the detection of expired antibiotic tablets. The work focuses on a specific antibiotic drug and represents the preliminary study upst...
Recombinant adeno-associated viral vectors (rAAV) represent a gene therapy tool of ever-increasing importance. Their utilization as a delivery vehicle for gene replacement, silencing and editing, among other purposes, demonstrate considerable versati...
The rapidly evolving field of machine learning (ML), along with artificial intelligence in a broad sense, is revolutionising many areas of healthcare, including laboratory medicine. The amalgamation of the fields of ML and patient-based real-time qua...
Within this second piece of the two-part series of phage manufacturing considerations, we are examining the creation of a drug product from a drug substance in the form of formulation, through to fill-finish. Formulation of a drug product, in the cas...
Today, food safety and quality are some of the main concerns of consumer and health agencies around the world. Our current lifestyle and market globalization have led to an increase in the number of people affected by food poisoning. Foodborne illnes...
Over the past decade, the liquid chromatography–mass spectrometry (LC-MS)-based Multi-Attribute Method (MAM) has successfully transitioned from development laboratories into Quality Control (QC) environments. Driven by pharmaceutical Quality by...
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