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Diagnostics
Special Issues
Biochemical Testing Applications in Clinical Diagnosis—2nd Edition
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Biochemical Testing Applications in Clinical Diagnosis—2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 640

Special Issue Editor

Dr. Donatella Coradduzza

E-Mail Website
Guest Editor
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
Interests: biochemistry; molecular biology; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Diagnostics is dedicated to the applications of biochemical testing in clinical diagnosis. It focuses on the use of advanced biochemical techniques to improve the accuracy and timeliness of medical diagnoses. The articles cover a wide range of topics, including the identification of new biomarkers, the development of innovative analytical techniques, and the implementation of point-of-care tests. The main objective is to highlight how biochemical tests can revolutionize early diagnosis and disease management, improving clinical outcomes. Original contributions, reviews, and clinical studies are invited to provide a comprehensive overview of the latest discoveries and practical applications in this crucial field of medicine.

Topics of interest include, but are not limited to, the following:

  1. Development and validation of new biomarkers for early diagnosis.
  2. Innovations in biochemical analytical techniques to enhance diagnostic accuracy.
  3. Applications of point-of-care tests in clinical practice.
  4. Biochemical monitoring and evaluation of therapeutic response.
  5. Clinical studies and case reports on biochemical diagnosis.
  6. Integration of biochemical tests with other diagnostic modalities for a more comprehensive diagnosis.
  7. Studies on the overuse of biochemical tests.

We look forward to receiving your contribution.

Dr. Donatella Coradduzza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biochemical testing
  • clinical diagnosis
  • biomarkers
  • point-of-care tests
  • innovative analytical techniques

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

17 pages, 1018 KB  
Article
Assessment of CTX, PINP, and Vitamin D-Binding Protein in Gingival Crevicular Fluid and Saliva During Fixed Orthodontic Treatment
by Ali Batuhan Bayırlı, Ebru Yurdakurban, Mehmetcan Uytun, Fulden Cantaş Türkiş and Ercan Saruhan
Diagnostics 2026, 16(1), 30; https://doi.org/10.3390/diagnostics16010030 - 22 Dec 2025
Viewed by 368
Abstract
Background/Objectives: Orthodontic tooth movement is a biological process involving coordinated bone resorption and formation in response to mechanical stimulation. The aim of this study was to evaluate the temporal changes in C-terminal telopeptide of type I collagen (CTX), procollagen type I N-terminal [...] Read more.
Background/Objectives: Orthodontic tooth movement is a biological process involving coordinated bone resorption and formation in response to mechanical stimulation. The aim of this study was to evaluate the temporal changes in C-terminal telopeptide of type I collagen (CTX), procollagen type I N-terminal propeptide (PINP), and vitamin D-binding protein (VDBP) levels in gingival crevicular fluid (GCF) and saliva during fixed orthodontic treatment, as well as to assess the relationships among these biomarkers. Methods: The study included a total of 27 systemically and periodontally healthy individuals comprising 14 males and 13 females. Clinical periodontal parameters were assessed at three time points: before treatment (T0), at 24–48 h (T1), and on day 40 (T2). GCF and saliva samples were collected at the same time points. Levels of CTX, PINP and VDBP in GCF and saliva were quantified using enzyme-linked immunosorbent assay. The data were analyzed using both parametric and non-parametric statistical tests. Temporal changes across the three time points were evaluated using mixed-effects models, differences between GCF and saliva biomarker levels were assessed using paired tests, and correlations were examined using Spearman correlation analysis. Results: GCF and salivary CTX levels demonstrated a significant increase from T0 to T1, while PINP levels exhibited a substantial rise from T1 to T2 (p < 0.001). Levels of VDBP in both GCF and saliva did not demonstrate significant temporal changes (p > 0.05). Higher VDBP levels in both fluids were found to be negatively associated with increases in CTX and positively associated with increases in PINP (p < 0.05). Furthermore, salivary CTX and VDBP levels exhibited a consistent increase compared to those measured in GCF at all time points (p < 0.05). Conclusions: Fixed orthodontic forces elicit sequential resorptive and formative responses in both GCF and saliva. The potential of VDBP to function as a local modulator is indicated, with the capacity to influence the balance between osteoclastic and osteoblastic activity. The evaluation of these biomarkers in non-invasive biological samples may offer a valuable approach for monitoring bone metabolism throughout orthodontic treatment. Full article
(This article belongs to the Special Issue Biochemical Testing Applications in Clinical Diagnosis—2nd Edition)
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