Special Issue "Microfluidic Tools for High-Throughput Screening"
Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 16637
Interests: microfluidics; radiochemical synthesis; radiochemical analysis; automation; molecular imaging
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There has been tremendous progress over the last several years in the development and commercialization of microfluidic technologies for high-throughput screening (HTS) and library generation. Across a wide range of applications, microfluidic HTS has numerous advantages over conventional tools, including reduced sample and reagent volumes, improved measurement sensitivity, higher density of assays and reagent/sample storage, and implementation of multi-step assays in simple multifunctional microfluidic devices.
HTS has been implemented in diverse types of microfluidic devices including (1) analogs of microplates in which assays are performed in an array of tiny wells or chambers, (2) array-based systems in which samples/reagents are flowed over an array of immobilized or trapped reagents/samples to perform assays, or (3) droplet-in-oil based systems in which assays are performed in a series of isolated droplets separated by an oil stream. Depending on the assay, the devices may manipulate single cells, 2D or 3D cell cultures, tissues, spheroids, small organisms, or biomolecules (e.g., proteins, nucleic acids, peptides), etc. In order to identify “hits”, readout may rely on fluorescence, luminescence, nanoparticle binding, electrical impedance, radioactivity, microscopy (e.g., cell morphology, crystal formation), size, PCR amplification and a multitude of other outputs.
For this Special Issue, we invite original research or review papers that focus on the many current and emerging microfluidic platforms for high-throughput screening, as well as their diverse applications.
Prof. R. Michael van Dam
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- micro total analysis systems
- lab on a chip
- combinatorial synthesis
- high-throughput screening