Marine Natural Products with Anti-aging Activity

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 4469

Special Issue Editors


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Guest Editor
Advanced Technology Center for Aging Research, IRCCS INRCA, 60121 Ancona, Italy
Interests: anti-aging; marine biotoxins; mussels; immune responses; storage lipids

E-Mail Website
Guest Editor
Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, Ancona, Italy
Interests: biology of aging; biogerontology; experimenetal gerontology; geroscience; cellular senescence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Aging is a complex biological process underlined by the dysfunction of critical cellular pathways and metabolisms and characterized by an increased risk of developing diseases. Since the older population is rapidly growing, research on new strategies to promote healthy aging is becoming increasingly essential.

The marine environment represents a great source of natural products. The wide and unique chemical diversity of marine molecules results in a variety of mechanisms of action, many of which could target the aging pathways.

This Special Issue will be focused on the potential of marine natural products to address the aging process at different levels and in different models. Suitable topics may include interactions between marine molecules and the determinants of aging, effects of marine molecules in delaying the aging progression and extending healthspan/lifespan, as well as candidate drugs to treat age-related diseases. Studies describing molecules involved in the longevity of long-living marine species are also welcome.

Dr. Maria Elisa Giuliani
Dr. Marco Malavolta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • age-related diseases
  • longevity
  • healthspan
  • marine molecules
  • marine organisms
  • drug discovery

Published Papers (2 papers)

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Review

22 pages, 1255 KiB  
Review
Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes
by Maria Elisa Giuliani, Giorgia Bigossi, Giovanni Lai, Serena Marcozzi, Dario Brunetti and Marco Malavolta
Mar. Drugs 2024, 22(5), 210; https://doi.org/10.3390/md22050210 - 3 May 2024
Viewed by 2622
Abstract
Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population and often require prolonged use of multiple drugs due to their chronic nature and the high proportion [...] Read more.
Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population and often require prolonged use of multiple drugs due to their chronic nature and the high proportion of co-morbidities. Hence, research is constantly looking for novel, effective molecules to treat CVD and T2DM with minimal side effects. Marine active compounds, holding a great diversity of chemical structures and biological properties, represent interesting therapeutic candidates to treat these age-related diseases. This review summarizes the current state of research on marine compounds for the treatment of CVD and T2DM, from pre-clinical studies to clinical investigations and approved drugs, highlighting the potential of marine compounds in the development of new therapies, together with the limitations in translating pre-clinical results into human application. Full article
(This article belongs to the Special Issue Marine Natural Products with Anti-aging Activity)
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16 pages, 304 KiB  
Review
Marine Natural Products Rescuing the Eye: A Narrative Review
by Filippo Lixi, Livio Vitiello and Giuseppe Giannaccare
Mar. Drugs 2024, 22(4), 155; https://doi.org/10.3390/md22040155 - 28 Mar 2024
Viewed by 1439
Abstract
Different degrees of visual impairment lead to a decrease in patient wellbeing, which has an adverse effect on many facets of social and professional life. Eye disorders can affect several parts of the eye, most notably the retina and the cornea, and the [...] Read more.
Different degrees of visual impairment lead to a decrease in patient wellbeing, which has an adverse effect on many facets of social and professional life. Eye disorders can affect several parts of the eye, most notably the retina and the cornea, and the impacted areas might share a common form of cellular damage or dysfunction (such as inflammation, oxidative stress and neuronal degeneration). Considering that marine organisms inhabit a broad variety of marine habitats, they display a great degree of chemical diversity. As a result, molecules with a marine origin are receiving more and more attention in the hopes of developing novel therapeutic approaches. For instance, fucoxanthin has been demonstrated to be effective in protecting the retina against photo-induced damage, while largazole, astaxanthin and spirulina have all shown antioxidant, anti-inflammatory and antiapoptotic activities that can be useful for the management of several ocular diseases, such as age-related macular degeneration and ocular surface disorders. The aim of this review is to analyze the scientific literature relating to the therapeutic effects on the eye of the main natural marine products, focusing on their mechanism of action and potential clinical uses for the management of ocular diseases. Full article
(This article belongs to the Special Issue Marine Natural Products with Anti-aging Activity)
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