Quality Control and Standardization of Plant-Based Pharmaceuticals

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 25 October 2026 | Viewed by 378

Editors


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Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal
Interests: pharmacognosy; medicinal plants; ethnobotany; ethnopharmacology; ethnopharmacy; natural products; quality control; drug discovery; pharmacological validation; safety and toxicological assessment
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Guest Editor
Centre for Natural Products Discovery, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK
Interests: natural products chemistry; phytochemical analysis; pharmaceutical and cosmeceutical formulation; drug discovery from natural sources; phytotherapy and herbal medicines

Special Issue Information

Dear Colleagues,

Plant-based pharmaceuticals and herbal medicines are increasingly recognized as valuable sources of therapeutic agents and innovative drug leads. Natural products continue to contribute significantly to modern pharmacotherapy, with many clinically relevant drugs originating from plant secondary metabolites. The growing global demand for phytotherapeutic products reflects renewed scientific and industrial interest in plant-derived bioactive compounds. However, despite their widespread use, important challenges remain regarding quality control, reproducibility, safety, and regulatory acceptance of herbal medicines. Variability in phytochemical composition caused by geographical origin, cultivation practices, harvesting conditions, and processing methods often leads to inconsistencies in efficacy and safety profiles. Consequently, the establishment of standardized analytical approaches and scientifically validated quality assessment strategies has become a priority for both academic research and pharmaceutical development.

This Special Issue aims to present and disseminate the most recent advances related to quality control, standardization, and pharmaceutical development of plant-based products. We consider contributions addressing phytochemical characterization, authentication methods, analytical quality assessment, pharmacological validation, safety evaluation, and innovative formulation strategies for herbal medicines and natural products. Original research articles, reviews, and methodological studies that strengthen scientific evidence and promote reproducibility in phytomedicine and natural product drug discovery are particularly encouraged.

Topics of interest for publication include, but are not limited to, the following:

  • Quality control strategies for herbal medicines and plant-based pharmaceuticals;
  • Phytochemical analysis and characterization of secondary metabolites;
  • Natural products chemistry and metabolomic approaches;
  • Authentication and standardization of medicinal plants;
  • Relationship between phytochemical composition and pharmacological properties;
  • Safety assessment and toxicological evaluation of herbal products;
  • Pharmaceutical and cosmeceutical formulation of plant-derived compounds;
  • Drug discovery from natural sources;
  • Advances in phytotherapy and evidence-based herbal medicines;
  • Regulatory perspectives and quality assurance of plant-based therapeutics.

Dr. Maryam Malmir
Dr. Emran Habibi
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • quality control and standardization of plant-based products
  • authentication of medicinal plants
  • phytochemical characterization
  • secondary marker metabolites
  • pharmacological validation
  • safety and toxicological assessment
  • pharmaceutical formulation
  • evidence-based herbal medicine
  • ethnopharmacology
  • regulatory aspects of herbal medicines
  • reproducibility in natural products research

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Published Papers (1 paper)

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Research

15 pages, 5289 KB  
Article
Portable, Rapid, and Cost-Effective Smartphone-Based Colorimetric Quantification of Total Lactones in Andrographis paniculata
by Sutasinee Apichai, Suphakorn Katib, Teerapat Ouirungroj, Thanawat Pattananandecha, Kanokwan Kiwfo, Fumihiko Ogata, Naohito Kawasaki, Kate Grudpan and Chalermpong Saenjum
Pharmaceuticals 2026, 19(7), 1110; https://doi.org/10.3390/ph19071110 (registering DOI) - 18 Jul 2026
Abstract
Background/Objectives: Andrographis paniculata is listed in the Thai National List of Essential Medicines. The Thai Herbal Pharmacopoeia specifies the required contents of total lactones and andrographolide for the quality control of the aerial parts of A. paniculata. Effective pre-harvest quality control [...] Read more.
Background/Objectives: Andrographis paniculata is listed in the Thai National List of Essential Medicines. The Thai Herbal Pharmacopoeia specifies the required contents of total lactones and andrographolide for the quality control of the aerial parts of A. paniculata. Effective pre-harvest quality control throughout the cultivation period is essential to ensure compliance with these quality standards. In this study, we aimed to develop a portable smartphone-based colorimetric method for the determination of total lactone content, thereby facilitating in-field quality control of A. paniculata raw materials. Methods: Methanol was used as the extraction solvent, and the analytes were extracted using a simple procedure derived from the United States Pharmacopeia concept. The colorimetric reaction was based on a charge-transfer reaction between the α,β-unsaturated γ-lactone moiety and 3,5-dinitrobenzoic acid, producing a red-purple product in a microwell plate. The delta-green intensity of the reaction product was captured as an andrographolide equivalent using a smartphone camera and quantified through digital image processing with a custom-developed mobile application. Results: A linear working range of 15–100 µg/mL was exhibited with limits of detection and quantification of 4.9 and 15.0 µg/mL, respectively. The practical applicability of the developed method was evaluated using A. paniculata samples and compared with the conventional spectrophotometric method. The results showed excellent agreement between the two methods, with a correlation coefficient of 0.9986. Conclusions: The results of this study suggest that this portable and rapid method is feasible for in-field/on-site analysis to facilitate pre-harvest quality control throughout the cultivation period, ensuring that harvested A. paniculata materials comply with established quality standards for plant-derived natural active pharmaceutical ingredients (NAPIs). The proposed method has the potential to promote sustainable production and responsible resource utilization by improving the quality of herbal raw materials intended for the manufacture of herbal medicines and dietary supplements, in line with UN-SDG #12 and #3. Full article
(This article belongs to the Special Issue Quality Control and Standardization of Plant-Based Pharmaceuticals)
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