TBC1D4 (AS160) and TBC1D1 are Rab GTPase-activating proteins that play a key role in the regulation of glucose and possibly the transport of long chain fatty acids (LCFAs) into muscle and fat cells. Knockdown (KD) of TBC1D4 increased CD36/SR-B2 and F...
This manuscript is the corrected version of a previously published paper. Glucose uptake by mammalian cells is a key mechanism to maintain cell and tissue homeostasis and relies mostly on plasma membrane-localized glucose transporter proteins (GLUTs)...
Background: Mitochondria–lysosome coupling and mitophagy are fundamental to mitochondrial homeostasis, yet the determinants governing this process remain incompletely defined. This study distinguished the regulatory modes of TBC1D15 and establi...
Few papers have focused on small guanosine triphosphate (GTP)-binding proteins and their regulation during spermatogenesis. TBC1D21 genes (also known as male germ cell RAB GTPase-activating protein MGCRABGAP) are related to sterility, as determined t...
APSL (active peptide from shark liver) is a hepatic stimulator cytokine from the liver of Chiloscyllium. It can effectively protect islet cells and improve complications in mice with alloxan-induced diabetes. Here, we demonstrate that the APSL sequen...
Human pathogenic variants of TBC1D24 are associated with clinically heterogeneous phenotypes, including recessive nonsyndromic deafness DFNB86, dominant nonsyndromic deafness DFNA65, seizure accompanied by deafness, a variety of isolated seizure phen...
Ramon syndrome (MIM 266270) is an extremely rare genetic syndrome, characterized by gingival fibromatosis, cherubism-like lesions, epilepsy, intellectual disability, hypertrichosis, short stature, juvenile rheumatoid arthritis, and ocular abnormaliti...
Triple-negative breast cancer (TNBC) is a major concern among the different subtypes of breast cancer (BC) due to the lack of effective treatment. In a previous study by our group aimed at understanding the difference between TNBC and non-TNBC tumors...
Exercise, contraction, and pharmacological activation of AMP-activated protein kinase (AMPK) by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) have all been shown to increase muscle insulin sensitivity for glucose uptake. Intriguingly, improve...
Chronic alcohol consumption retards lipophagy, which contributes to the pathogenesis of liver steatosis. Lipophagy-related Rab7 has been presumed as a crucial regulator in the progression of alcohol liver disease despite elusive mechanisms. More impo...
The small GTPase, Rab7a, and the regulators of its GDP/GTP-binding status were shown to have roles in both endocytic membrane traffic and autophagy. Classically known to regulate endosomal retrograde transport and late endosome-lysosome fusion, earli...
Various intrinsic and extrinsic factors can interfere with the process of protein folding, resulting in protein aggregates. Usually, cells prevent the formation of aggregates or degrade them to prevent the cytotoxic effects they may cause. However, d...
Fat taste is emerging as a sixth primary taste modality, with CD36 identified as a key receptor for oral detection of long-chain fatty acids. Tastants bind to receptors on taste bud cells (TBCs), triggering intracellular calcium mobilization, neurotr...
Thermal barrier coatings (TBCs) have been developed to protect superalloys against high-temperature heat fluxes, which are required for the development of high-performance gas turbines. TBCs have porous structures, which are densified by sintering. T...
Beneficial properties achieved by nanostructuring effects in materials have generated tremendous interests in applications in surface engineering, especially in thermal barrier coatings (TBC). Limitations in conventional TBC processing for gas turbin...
This paper presents an experimental study on simultaneously measuring the elastic modulus and residual stress of a thermal barrier coating (TBC) after different isothermal heat treatments. The elastic modulus and residual stress of TBCs were theoreti...
Motivated by a recently predicted structure of diamond-like BC2 with a high claimed hardness of 56 GPa (J. Phys. Chem. C 2010, 114, 22688–22690), we focus on whether this tetragonal BC2 (t-BC2) is superhard or not in spite of such an ultrahigh theore...
This work presents a numerical investigation of the combined effects of thermal barrier coating (TBC) with mainstream turbulence intensity (Tu) on a modified vane of the real film-cooled nozzle guide vane (NGV) reported by Timko (NASA CR-168289). Usi...
Either to obtain desirable microstructures by adjusting processing parameters or to predict the properties of a thermal barrier coating (TBC) according to its microstructure, fast and reliable quantitation of the microstructure is imperative. In this...
Denervation rapidly induces insulin resistance (i.e., impairments in insulin-stimulated glucose uptake and signaling proteins) in skeletal muscle. Surprisingly, whether this metabolic derangement is long-lasting is presently not clear. The main goal...
Insulin signaling plays a key role in glucose uptake, glycogen synthesis, and protein and lipid synthesis. In insulin-resistant states like obesity and type 2 diabetes mellitus, these processes are dysregulated. Regular physical exercise is a potenti...
Thick thermal barrier coatings (TBCs) are the main choice in the aviation industry due to their ability to handle elevated temperature exposure in turbines. However, the efficacy of thick TBCs has not been adequate. This study presents a highly durab...
To address how skeletal muscle contributes to postprandial hyperglycemia, we performed skeletal muscle transcriptome analysis of diabetic Goto-Kakizaki (GK) and control Wistar rats by RNA sequencing (RNA-Seq). We obtained 600 and 1785 differentially...
p-tBu-calix[4]arene (H4TBC[4]) has proven to be an incredibly versatile ligand for the synthesis of 3d- and 3d/4f- clusters, in particular those containing mixed-valent Mn ions. These are of interest to the magnetochemist for the diversity of magneti...
In this study, an extended layerwise/solid-element (XLW/SE) method is developed for the thermo–chemo–mechanical (TCM) coupling problem of an aero-engine turbine blade with thermal barrier coatings (TBCs). The method consists of two parts,...
We computationally investigate the conformational behavior, “bridging” chain, between different the phase-separated domains vs “looping” chain on the same domain, for two chain architectures of ABA triblock copolymers, one wit...
In this article, a theoretical 1-D heat transfer model and conjugate heat transfer numerical simulation was carried out to evaluate the thermal insulation of TBCs under different factors. The relationship of temperature-drop between the inner or oute...
Awareness of the importance of the microbial contamination of air and surfaces has increased significantly during the COVID-19 pandemic. The aim of this study was to evaluate the presence of bacteria and fungi in the air and on surfaces within some c...
β-Ga2O3 suffers from extremely poor thermal conductivity, resulting in a severe self-heating effect. Integrating β-Ga2O3 with high-thermal-conductivity foreign substrates is one of the promising solutions to improve the thermal performance...
Due to their complex genotypes, low in vitro regeneration rates, and difficulty in obtaining transgenic plants, studies concerning basic biological research and molecular breeding in Tartary buckwheat (TB) are greatly limited. In this study, the hypo...
The modeling of the turbine blades in aero-parts presents difficulties in conventional domain solution techniques, especially when internal cooling air passages and a thermal barrier coating (TBC) are applied. This paper presents a very efficient 3D...
Hexi cattle are a local cattle population endemic to the Hexi Corridor in Gansu Province, China, and exhibit strong adaptability to the region’s arid continental environment. However, comprehensive genomic investigations of this population are...
Impaired skeletal muscle glucose uptake is a key feature in the development of insulin resistance and type 2 diabetes. Skeletal muscle glucose uptake can be enhanced by a variety of different stimuli, including insulin and contraction as the most pro...
Accurately characterizing the internal porosity rate of thermal barrier coatings (TBCs) was essential for prolonging their service life. This work concentrated on atmospheric plasma spray (APS)-prepared TBCs and proposed the utilization of terahertz...
This paper presents two new step-up DC–DC converters that have high voltage gains and low voltage stresses across their main switches with respect to their output voltages. These high voltage gains are achieved with the help of voltage multipli...
The adipokine Neuregulin 4 (Nrg4) protects against obesity-induced insulin resistance. Here, we analyze how the downregulation of Nrg4 influences insulin action and the underlying mechanisms in adipocytes. Validated shRNA lentiviral vectors were used...
Achieving a supply chain that is resilient to potential unforeseen disruptions (e.g., strikes, floods, tsunamis, etc.) remains one of the vital concerns of decision makers (DMs). To build up a reactive supply chain plan towards resilience, the purcha...
A healthy, latently infected, diseased (HLD) plant model for botanical epidemics was defined for tomato bacterial canker (TBC) caused by the pathogenic plant bacteria, Clavibacter michiganensis subsp. michiganensis (Cmm). To estimate the infection pr...
To understand the oxidation behaviors of the NiCrAlY bond coats in the thermal barrier coatings (TBCs) under external loads, uniaxial tensile and compressive experiments of the TBCs in air at 900 °C for 100 h were investigated. Then, the experime...
Alaska pollack roe (APR) is a protein source that is usually salted and fermented, containing a high salt content. Using a combination of superheated steam roasting and smoking, we developed a new low-salt ready-to-eat APR variant, whose quality char...
This study aimed to investigate if a thermal barrier coating (TBC) affected the energy efficiency of 3D printers. In accordance with this purpose, the used TBC technique is clearly explained and adapted to a nozzle in a simulation environment. Brass,...
Raf kinase inhibitor protein (RKIP) plays a critical role in many signaling pathways as a multi-functional adapter protein. In particular, the loss of RKIP’s function in certain types of cancer cells results in epithelial to mesenchymal transit...
Oxidative stress (OS) plays a key role in autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by deficits in social communication, restricted interests, and repetitive behaviors. Recent evidence suggests that the TLDc [Tre2/Bu...
In 2022, the Nobel Prize in Chemistry was awarded to Bertozzi, Meldal, and Sharpless “for the development of click chemistry and biorthogonal chemistry”. Since 2001, when the concept of click chemistry was advanced by Sharpless laboratory...
Residual particles embedded at the bond coat/substrate (BC/SUB) interface after grit blasting can affect the failure behavior of thermal barrier coatings (TBCs) under thermal cycling. This study employed a 2D finite element model combining the cohesi...
The genetic and environmental determinants of serum propionylcarnitine concentrations (PC) remain largely unexplored. This study investigated the impact of genetic and environmental factors on serum propionylcarnitine levels in middle-aged and elderl...
In the last decade, there has been a boost in autophagy reports due to its role in cancer progression and its association with tumor resistance to treatment. Despite this, many questions remain to be elucidated and explored among the different tumors...
This study aimed to develop a model using Epstein–Barr virus (EBV)-associated hub genes in order to predict the prognosis of nasopharyngeal carcinoma (NPC). Differential expression analysis, univariate regression analysis, and machine learning...
Although the 3D structures of active and inactive cannabinoid receptors type 2 (CB2) are available, neither the X-ray crystal nor the cryo-EM structure of CB2-orthosteric ligand-modulator has been resolved, prohibiting the drug discovery and developm...
The health benefits of probiotics have been known for decades, but there has only been limited use of probiotics in the treatment of obesity. In this study, we describe, for the first time, the role of cell-free metabolites (CM) from Bacillus ginseng...
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