Special Issue "Small GTPases"
Deadline for manuscript submissions: closed (15 November 2018).
Interests: cell biology; animal cells; intracellular signal transduction; small GTPases; type II diabetes; insulin signaling; glucose transporter; skeletal muscle; adipocytes
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Special Issue in International Journal of Molecular Sciences: Small GTPases 2020
The family of signal transducing small GTPases serves as a molecular switch of intracellular signal transduction in eukaryotic cells. It has been implicated in a diverse array of cell functions, such as gene expression, cytoskeletal rearrangements, intracellular transport of vesicles, and macromolecular transport across the nuclear envelope. In humans, defects in small GTPase-mediated signaling are intimately involved in various diseases, including cancer. In contrast to heterotrimeric G proteins, another family of signal transducing GTPases, small GTPases act as a monomer (single polypeptide) attached to cell and intracellular membranes through post-translational lipid modifications. Virtually all small GTPases exist in either GDP-bound or GTP-bound conformation, interacting with specific regulatory and target proteins in a manner dependent on the bound GDP or GTP. In many cases, upstream signals, such as receptor-mediated signals, stimulate the formation of the GTP-bound conformation, which in turn activates downstream targets.
This Special Issue “Small GTPases” aims to provide new insights into physiological functions and regulatory mechanisms of any kinds of signal transducing small GTPases in the cell. Authors are invited to submit original research and review articles related to these subjects.Prof. Dr. Takaya Satoh
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- animal cell
- cell growth
- cell motility
- guanine nucleotide exchange
- human disease
- protein-protein interaction
- signal transduction
- vesicular transport