Rab escort protein 1 (REP1), a component of the Rab geranyl-geranyltransferase 2 complex, plays a role in Rab protein recruitment in proper vesicles during vesicle trafficking. In addition to having well-known tissue degenerative phenotypes in the RE...
Transcriptional gene silencing (TGS) in plants is a defense mechanism against DNA virus infection. The genomes of viruses in the Geminiviridae family encode several TGS suppressors. In this study, we induced de novo TGS against the transgenic GFP gen...
The Geminiviruses genome is a small, single strand DNA that replicates in the plant cell nucleus. Analogous to animal DNA viruses, Geminiviruses depend on the host replication machinery to amplify their genomes and only supply the factors required to...
The automatic classification of aluminum profile surface defects is of great significance in improving the surface quality of aluminum profiles in practical production. This classification is influenced by the small and unbalanced number of samples a...
The production of clinical-grade recombinant adeno-associated viral (AAV) vectors for gene therapy trials remains a major hurdle in the further advancement of the gene therapy field. During the past decades, AAV research has been predominantly focuse...
Porcine circovirus type 2 (PCV2) is one of the major threats to pig farms worldwide. Although PCV2 has been identified to promote IL-10 production, the detailed regulatory roles of PCV2 Rep for IL-10 production remain unclear. Herein, we first found...
Most object detection methods use rectangular bounding boxes to represent the object, while the representative points network (RepPoints) employs a point set to describe the object. The RepPoints can provide more fine-grained localization and facilit...
With the rapid development of Internet technology, the number of global Internet users is rapidly increasing, and the scale of the Internet is also expanding. The huge Internet system has accelerated the spread of bad information, including bad image...
Our previous study identified that the RepA protein encoded by the oat dwarf virus (ODV) was responsible for inducing a strong hypersensitive response (HR) during the virus infection in non-host tobacco plants. However, little was known about the mol...
To further improve the detection of smoke and small target smoke in complex backgrounds, a novel smoke detection model called RepVGG-YOLOv7 is proposed in this paper. Firstly, the ECA attention mechanism and SIoU loss function are applied to the YOLO...
Porcine circovirus-like virus (PCLV) is a member of circovirus that contains a single-strand DNA genome, which may be one of the pathogens that causes diarrheal symptoms in pigs. The Rep protein encoded by the genome of PCLV may be responsible for vi...
Beet curly top Iran virus (BCTIV) is a yield-limiting geminivirus belonging to the becurtovirus genus. The genome organization of BCTIV is unique such that the complementary strand of BCTIV resembles Mastrevirus, whereas the virion strand organizatio...
Pyrrolizidine alkaloids (PAs) present distinct toxicity potencies depending on their metabolites and in vivo toxicokinetics. To represent the potency differences of various PAs, the interim relative potency (REP) factors have been derived. However, l...
The major route for Toxoplasma gondii (T. gondii) infection is through the ingestion of foods contaminated with oocyst from cat faeces. The microscopic detection of T. gondii oocysts in cat faeces is challenging, which contributes to the failure of d...
With the worldwide carbon neutralization boom, low-speed heavy load bearings have been widely used in the field of wind power. Bearing failure generates impulses when the rolling element passes the cracked surface of the bearing. Over the past decade...
The therapeutic benefit provided by anti-vascular endothelial growth factor (VEGF) for patients with vision-threatening conditions such as diabetic retinopathy (DR) demonstrates the important role of VEGF in this affliction. Cytokines, which can be e...
The attitude sensor of the aircraft can give feedback on the perceived flight attitude information to the input of the flight controller to realize the closed-loop control of the flight attitude. Therefore, the fault diagnosis of attitude sensors is...
Isolation and characterization of circular replicase-encoding single-stranded (ss) DNA from animal, plant and environmental samples are rapidly evolving in virology. We detected 21 circular DNA elements, including one genomoviral sequence, in individ...
With the advancement of deep neural networks, several methods leveraging convolution neural networks (CNNs) have gained prominence in the field of remote sensing object detection. Acquiring accurate feature representations from feature maps is a crit...
The RA3 plasmid, the archetype of IncU incompatibility group, represents a mosaic-modular genome of 45.9 kb. The replication module encompasses repA and repB (initiator) surrounded by two long repetitive sequences DR1 and DR2 of unknown function. Her...
Copiotrophic marine bacteria of the Roseobacter group (Rhodobacterales, Alphaproteobacteria) are characterized by a multipartite genome organization. We sequenced the genomes of Sulfitobacter indolifex DSM 14862T and four related plasmid-rich isolate...
Recent clinical research describes a subset of glioblastoma patients that exhibit REP prior to the start of radiation therapy. Current literature has thus far described this population using clinicopathologic features. To our knowledge, this study is...
The massive development of virtualized infrastructures, Internet of Things (IoT), and Wireless Sensor Network (WSN) in recent years has led to an increase in quality requirements for the management and reliability of underlay communication networks....
Several challenges limit effective pulp wound healing during vital pulp therapies (VPTs) and pulp regeneration in necrotic teeth. Recent advances in regenerative therapies using dental mesenchymal stem cells (MSCs) have shown promise for improving ti...
Systematic quantification and monitoring of forest biophysical and biochemical variables is required to assess the response of ecosystems to climate change and gain a deeper understanding of the carbon cycle. Red-Edge Position (REP) is a hyperspectra...
The rapid electrokinetic patterning (REP) technique has been demonstrated to enable dynamic particle manipulation in biomedical applications. Previous studies on REP have generally considered particles with a size less than 5 μm. In this study, a...
Due to their role in methane production, methanoarchaea are of high ecological relevance and genetic systems have been ever more established in the last two decades. The system for protein expression in Methanosarcina using a comprehensive shuttle ve...
23 December 2022
Resource and environmental carrying capacity (RECC) is an important basis for achieving sustainable urban development, and analysis of the relationship between regional resources and human activities is of great significance for sustainable regional...
Choroideremia is an X-linked recessive condition presenting in males, with progressive degeneration of retinal and choroidal tissues leading to progressive visual loss. Its pathological mechanism is due to alterations in the CHM gene that encodes for...
Today’s IP networks are experiencing a high increase in used and connected Internet of Things (IoT) devices and related deployed critical services. This puts increased demands on the reliability of underlayer transport networks. Therefore, mode...
Carrier-free ultra-wideband sensors have high penetrability anti-jamming solid ability, which is not easily affected by the external environment, such as weather. Also, it has good performance in the complex jungle environment. In this paper, we prop...
With the increasing demand for road defect detection, existing deep learning methods have made significant progress in terms of accuracy and speed. However, challenges remain, such as insufficient detection precision for detection precision for road...
This paper presents a workflow for B-rep solid model generation of organic objects using T-splines constructed with quad-meshes. The aim is the creation of geometrically and topologically consistent B-rep solid models of heritage objects featuring or...
Instance segmentation in agricultural robotics requires a balance between real-time performance and accuracy. This study proposes a lightweight pomelo image segmentation method based on the YOLOv8n-seg model integrated with the RepGhost module. A pom...
Choroideremia (CHM) is a X-linked recessive chorioretinal dystrophy due to deficiency of the CHM gene product, i.e., Rab escort protein isoform 1 (REP1). To date, gene therapy for CHM has shown variable effectiveness, likely because the underlying pa...
The ability of uncrewed aerial vehicles (UAVs) to hover, recognize, and localize ground targets is crucial for efficient and accurate intelligent low-altitude operations, such as material delivery, emergency rescue, and firefighting. This paper prese...
The analysis of the relationship between regional resources and environment and human activities plays an important role in sustainable regional development. This study proposes the pressure–capacity–governance (PCG) model, an analytic fr...
We characterized the composition, diversity, and potential bacterial aerosol sources in Athens’ urban air by DNA barcoding (analysis of 16S rRNA genes) during three seasons in 2019. Air samples were collected using the recently developed Rutger...
Residential demand response (DR) programs are generally administered through an electricity distribution utility, or an electric grid operator. These programs typically reduce electricity consumption by inducing behavioral changes in the occupants of...
Exercise is a prevailing topic in modern society as more people are pursuing a healthy lifestyle. Physical activities provide significant benefits to human well-being from the inside out. Human pose estimation, action recognition and repetitive count...
A key prerequisite for the establishment of digitalized sheep farms and precision animal husbandry is the accurate identification of each sheep’s identity. Due to the uncertainty in recognizing sheep faces, the differences in sheep posture and...
Oil storage tank detection and classification in synthetic aperture radar (SAR) images play a vital role in monitoring energy distribution and consumption. Due to the SAR side-looking imaging geometry and multibouncing scattering mechanism, dense oil...
In this paper we present a method that automatically yields Boundary Representation Models (B-rep) for indoors after processing dense point clouds collected by laser scanners from key locations through an existing facility. Our objective is particula...
We characterized the cryptic plasmid pM27181 (15,416 bp) isolated from the Stutzerimonas stutzeri strain DIA-8. Sequencing and bioinformatic analysis allowed identification of 20 open reading frames, including genes involved in replication (rep), mob...
Accurate identification of weed species is a fundamental task for promoting efficient farmland management. Existing recognition approaches are typically based on either conventional Convolutional Neural Networks (CNNs) or the more recent Vision Trans...
Rolling circle replication (RCR) is ubiquitously used by cellular and viral systems for genome and plasmid replication. While the molecular mechanism of RCR has been described, the structural mechanism is desperately lacking. Circular-rep encoded sin...
Cycloviruses are circular Rep-encoding single-stranded DNA (CRESS-DNA) viruses detected in a wide range of biological and environmental samples, although the natural hosts and biological significance of many members of the genus remain poorly underst...
This study examines the market reaction to the approval of the Nature Restoration Law, a key component of the EU Biodiversity Strategy, and its implications for biodiversity-related financial risks. Using an event study methodology, we analyze the eq...
Recombinant adeno-associated virus (AAV) vectors have broad application prospects in the field of gene therapy. The establishment of low-cost and large-scale manufacturing is now the general agenda for industry. The baculovirus-insect cell/larva expr...
Open-source 3D printers mean objects can be quickly and efficiently produced. However, design and fabrication parameters need to be optimized to set up the correct printing procedure; a procedure in which the characteristics of the printing materials...
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