Water resource management in the Sahelian-Sudanian transition zone faces growing uncertainty under climate change, yet hydrological projections remain scarce for the Oti-Pendjari basin (West Africa). This study develops an integrated modelling chain...
Background/Objectives: Melanoma-associated antigen A3 (MAGEA3) is a cancer–testis antigen with potential biological and prognostic relevance in pancreatic ductal adenocarcinoma (PDAC). This study evaluated the association between OTI1H1-defined...
Biodiversity conservation planning is highly important in the current context of global change. Biodiversity conservation can be achieved by understanding changes in land use at the landscape scale. Such understanding is needed to reverse the unprece...
Flood damage in West Africa has increased appreciably during the last two decades. Poor communities are more at risk due to the vulnerability of their livelihoods, especially in rural areas where access to services and infrastructures is limited. The...
Colorectal cancer (CRC) is one of the most prevalent and deadly forms of cancer. It is universally treated with a combination of the DNA damaging chemotherapy drugs irinotecan, 5-Fluorouracil (5-FU), and oxaliplatin. CHD1L is a novel oncogene that pl...
The Chromodomain helicase DNA-binding protein 1-like (CHD1L) is a nucleosome remodeling enzyme, which plays a key role in chromatin relaxation during the DNA damage response. Genome editing has shown that deletion of CHD1L sensitizes cells to PARPi,...
The second and third most frequently diagnosed cancers worldwide are breast (2.3 million new cases) and colorectal (1.9 million new cases), respectively. Although advances in cancer therapies and early detection have improved the overall survival of...
Topoisomerases are essential enzymes that recognize and modify the topology of DNA to allow DNA replication and transcription to take place. Topoisomerases are divided into type I topoisomerases, that cleave one DNA strand to modify DNA topology, and...
It is with profound sadness and a deep sense of loss that we mourn the passing of Professor Andrew Otis Jackson on 6 July 2025 [...]
Water shortages across the globe have increased due to climate change among other factors with negative impacts expected at the river basin level. Anticipating these impacts will help experts act in a timely manner to avoid a future water crisis. As...
Small streams in urbanized rural areas receive loads of P from various, often episodic, sources. This paper addresses, through a tracer test with
The city of Acapulco was impacted by two near-consecutive hurricanes. On 25 October 2023, Hurricane Otis made landfall, reaching the highest Category 5 storm on the Saffir–Simpson scale, causing extensive coastal destruction due to extreme wind...
All available satellite altimetry, coastal and marine data have been used to develop a new assimilative barotropic tidal model over the Great Barrier Reef (GBR) and Coral Sea using the Oregon State University Tidal Inverse Software (OTIS) with the sp...
Employee retention is a strategic priority for organizations operating in increasingly competitive labor markets, yet predicting long-term employee departure remains a critical challenge. This study examines the longitudinal validity of the Ordinal T...
This paper provides the test results of the fatigue crack growth in notched specimens under tension. The tests were performed on plane specimens with external blunt two-sided notches at room temperature. The tested material was O–Ti2AlNb titani...
Immunosenescence is the adverse change in the human immune function during aging, leaving older people more prone to an increased risk of infections and morbidity. Acute upper respiratory tract infections (URTIs) are very common among older people, o...
In Finland, all fatal on-road and off-road motor vehicle crashes are subject to an in-depth investigation coordinated by the Finnish Crash Data Institute (OTI). This study presents an exploratory and two-step cluster analysis of fatal pedestrian cras...
The ecosystem-based adaptation (EbA) strategy is considered an effective approach to address the impact of climate change while ensuring the continued provision of ecosystem services on which farming depends. However, understanding the EbA’s ef...
Cancer therapy is often associated with severe side effects such as drug induced weight loss, also known as chemotherapy-induced cachexia. The aim of this study was to investigate the effects of a multispecies probiotic (OMNi-BiOTiC® 10 AAD) in a...
Lake Seyfe, designated a first-degree natural site (1989), a Nature Conservation Area (1990), and a Ramsar Site (1994), is a shallow saline wetland internationally important for flamingos and supports Great Bustard (Otis tarda) habitats documented in...
Background Coronavirus disease 2019 (COVID-19) can be complicated by interstitial pneumonia, possibly leading to severe acute respiratory failure and death. Because of variable evolution ranging from asymptomatic cases to the need for invasive ventil...
24 November 2023
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer and the fifth cause of cancer-related deaths worldwide with a poor 5-year survival. SOX family genes play a role in the processes involved in cancer development such as epithel...
Factors regulating the genesis and expansion of basal progenitor cell sub-populations, including intermediate progenitor cells, are critical determinants of cortical neurogenesis and brain growth. Epigenetic (chromatin) marks have emerged as notable...
SiC is one of the most important ceramics at present due to its excellent properties and wide range of applications. The industrial production method, known as the Acheson method, has not changed in 125 years. Because the synthesis method in the labo...
Advanced age or preexisting comorbidities have been characterized as risk factors for severe coronavirus disease 2019 (COVID-19) cases requiring hospitalization and intensive care. In recent years, clonal hematopoiesis (CH) of indeterminate potential...
The current study investigated the development of a sustainable thermo-chemical approach to effectively optimize MgO-waste activated GGBS formulations, using four types of magnesium oxide (MgO) waste materials with ground granulated blast-furnace sla...
Translational research often requires the testing of experimental therapies in primates, but research in non-human primates is now stringently controlled by law around the world. Tissues fixed in formaldehyde without glutaraldehyde have been thought...
Treated bentonite-rich soils used as liner materials in landfills may provide an effective solution to the problems of increased void ratios upon swelling at reduced suction as well as desiccation cracking when suction is increased during desaturatio...
The spinal ejaculation generator (SEG) is located in the central gray (lamina X) of the rat lumbar spinal cord and plays a pivotal role in the ejaculatory reflex. We recently reported that SEG neurons express the oxytocin receptor and are activated b...
Nursing home residents (NHR) have been targeted as a vaccination priority due to their higher risk of worse outcome after COVID-19 infection. The mRNA-based vaccine BTN2b2 was first approved in Europe for NHRs. The assessment of the specific vaccine...
Aim: Results from meta-analyses point to an association between vitamin D deficiency and the onset of diabetic retinopathy (DR). The objectives of the present study were to evaluate the association of vitamin D for the development of DR and to determ...
Male sexual function in mammals is controlled by the brain neural circuits and the spinal cord centers located in the lamina X of the lumbar spinal cord (L3–L4). Recently, we reported that hypothalamic oxytocin neurons project to the lumbar spinal co...
Evaluation of the effect of embodied carbon reduction using an optimized design section for a ground beam, use of supplementary cementitious materials, and replacement of normal aggregate with light weight aggregate on the mechanical properties of lo...
The role of gypsum level on the long-term strength and expansion of soil stabilised with different lime contents is not well understood. This research, therefore, studied the effect of varying gypsum concentrations of 0, 3, 6, and 9 wt% (equivalent t...
Clays encountered during road construction are mostly weak and result in major pavement failures due to their low California bearing ratio (CBR) and high swelling potential. In this study, sustainable and eco-friendly waste materials including brick...
Urban green spaces are linked to good human health and well-being, sustainable cities and communities, climate action, life on land and under water, as well as offering a platform for quality nature-based education. Their efficient management will no...
The past decade has seen most antimalarial drugs lose their clinical potency stemming from parasite resistance. Despite immense efforts by researchers to mitigate this global scourge, a breakthrough is yet to be achieved, as most current malaria chem...
Road pavement thickness and their depth of construction take a chunk of the overall cost of road construction. This has called for a need for reduced road pavement thickness by improving the engineering properties of subgrade such as the California b...
Sulfate-induced expansion resulting from the formation of ettringite in sulfate-bearing soil stabilised with calcium-based stabilisers is a problematic issue with technical and economic implications. Thus, this research examines the viability of the...
Commercial sodium hydroxide (NaOH) and sodium silicate (SS) have remained two of the leading alkaline activators widely used in producing geopolymer concrete, despite some identified negatives regarding their availability and additional CO2 emissions...
The main thrust of this research was to establish any benefits of mellowing, and the optimal moisture content (OMC) for compacting mellowed sulphate-bearing clay soil undergoing the stabilization process. Two three-day mellowing regimes were carried...
Lime stabilisation is one of the traditional methods of improving the engineering properties of lateritic soils for use as subgrade and foundation materials for the construction of road pavements and highway embankments. Understanding the mechanical...
Expansion of soils has been found to produce significant negative economic and environmental impact on various civil engineering infrastructure. This impact is more deleterious in soils containing sulphates, when treated with calcium-based stabilizer...
This study covers an in-depth investigation into the properties and practicality of the utilization of up to 40% Alumina Waste Filler (AWF) as a partial Portland Cement (PC) replacement material. AWF is a by-product from the recycling of aluminium, p...
Clayey soils endure adverse changes in strength and volume due to seasonal changes in moisture content and temperature. It has been well recognised that high cement content has been successfully employed in improving the mechanical properties of clay...
Glaucoma is considered a leading cause of blindness with the human eye being one of the body’s most delicate organs. Ocular diseases encompass diverse diseases affecting the anterior and posterior ocular sections, respectively. The human eye&rs...
Awareness of environmental sustainability is driving the shift from conventional Portland cement, a major contributor to carbon dioxide emissions, to more sustainable alternatives. This study focuses on developing a geopolymer concrete by optimizing...
The global demand for cement-based materials continues to rise, particularly in emerging economies where infrastructure and housing development are accelerating [...]
Sulfate soil stabilisation, while offering technical benefits for infrastructure, is a challenging process, complicated by the nucleation of ettringite, an expansive mineral that can cause soil deterioration. This study was undertaken to elucidate th...
The utilisation of magnesium oxide-based binders (M) as an alternative to hydrated calcium silicate materials is a promising avenue for binding methodologies. However, the efficacy of using silica fume (S) as a co-binder with magnesium oxide in sulph...
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