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Sci

Sci is an international, peer-reviewed, open access journal on all research fields published monthly online by MDPI.

All Articles (463)

Intense training loads alter the skin microbiome and defence mechanisms in athletes, yet adaptation profiles remain insufficiently characterised. This study evaluated the relationships between skin bacterial microbiome structure, antimicrobial activity, dermcidin levels, and acne severity in male professional hockey players compared with amateur athletes and non-athletes. One hundred men (18–57 years) were examined and allocated to six subgroups by exercise intensity and acne status. Microbiota composition was assessed by culture-based methods and MALDI-TOF identification, antimicrobial activity measured spectrophotometrically, dermcidin quantified by ELISA, and sweat proteome characterised by HPLC-MS. Staphylococcus epidermidis and Micrococcus luteus predominated in all groups. Exercise intensity, rather than acne, was the main determinant of total bacterial colonisation, which increased approximately tenfold from non-athletes to professional hockey players. In non-athletes, higher antimicrobial activity correlated with greater acne severity, whereas in professionals this relationship was absent and dermcidin levels showed an inverse association with acne severity. Proteomic analysis identified 17 polypeptides; dermcidin and prolactin-inducible protein were dominant in all groups, and calprotectin (S100-A8/A9) was detected exclusively in healthy professionals.

19 December 2025

Bacterial skin colonisation levels across participant groups stratified by exercise intensity and acne status. Box plots show median, interquartile range (IQR), and data distribution for professional hockey players (PRFH, PRFA), amateur athletes (AMATH, AMATA), and non-athletes (NATHH, NATHA). Total bacterial colonisation demonstrated a strong positive correlation with exercise intensity (p = 1.72 × 10−15, rs = 0.698) and increased approximately ten-fold from non-athletes (median: 56–61 CFU/cm2) to professionals (median: 711–740 CFU/cm2). No significant differences were observed between healthy and acne-affected individuals within any exercise level (all p > 0.05). Whiskers represent 1.5 × IQR; outliers are shown as individual points. Healthy professionals = PRFH; Professional with acne = PRFA; Healthy amateurs = AMATH; Amateurs with acne = AMATA; Healthy non-athletes = NATHH; Non-athletes with acne = NATHA.

Integrative Medicine has reached an important stage in its scientific evolution [...]

24 December 2025

This study examines the adoption of a low-cost model to support digital transformation in small- and medium-sized industrial enterprises (SMEs) within the context of Industry 4.0. In light of the need to increase operational efficiency while simultaneously reducing expenditure, it becomes a priority to employ innovative and cost-effective solutions. To evaluate this impact, the research applies the PICO (Population, Intervention, Comparison, Outcome) methodology, systematically assessing how the proposed model influences digital transformation and operational efficiency. Drawing on a case study, the findings demonstrate that implementing the low-cost model leads to significant cost reductions, gains in operational efficiency, and an acceleration of digital transformation in industrial organizations. The results indicate that the approach not only optimizes internal processes but also contributes to lowering the organization’s overall costs. The conclusions confirm the hypotheses, showing that the model achieves a balance between technological advancement and economic efficiency. The study provides relevant insights into the potential of technologies to simultaneously drive operational efficiency and digital transformation within the framework of Industry 4.0, offering an innovative pathway for companies seeking to digitalize while controlling costs. This research strengthens the existing body of knowledge on the synergy between digital transformation, cost efficiency, and operational performance in industrial settings.

18 December 2025

Plants have been used in medicine for centuries to treat various diseases, with alcohol and ethanol being known as universal solvents for the extraction of medicinal plant substances. This article sheds light on Artemisia absinthium (wormwood) and absinthe usage in the history of medicine. The invention of absinthe in Switzerland in 1797 made it an integral part of everyday life and the harmful effects of the massive consumption of this product were labelled absinthism. The medicinal properties of wormwood and absinthe are explored from the earliest records of the use of wormwood from the Ebers Papyrus (copies of which date back to 1550 BC) to the military consumption of absinthe during the French invasion of Algiers in 1830. As widely accepted, A. absinthium has both anthelmintic and antiprotozoal properties. In addition, modern medicine has demonstrated antibacterial, antifungal and antibiofilm properties of the plant extracts. In order to fully utilise the therapeutic potential of A. absinthium, advances in pharmaceutical technology are essential. One promising solution could lie in nanotechnological delivery systems. In our opinion absinthe is another impressive example of how tonics containing various herbal substances were used in the history of medicine to manage infections before their efficacy was later proven in vitro and in vivo.

15 December 2025

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Advanced Oxidation Process: Applications and Prospects
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Advanced Oxidation Process: Applications and Prospects

Editors: Gassan Hodaifa, Antonio Zuorro, Joaquín R. Dominguez, Juan García Rodríguez, José A. Peres, Zacharias Frontistis, Mha Albqmi

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Sci - ISSN 2413-4155