The Impact of COVID-19 Infection in Cancer

Dear Colleagues,

Highly pathogenic coronavirus SARS-CoV2 infection is spreading worldwide causing the COVID-19 disease. During such infection that predominantly interests the lungs, a massive release of inflammatory cytokines may contribute to the destruction of infected alveolar cells and induce fibrosis and endothelial cell damage, promoting the activation of the coagulation pathway, which worsens the local clinical picture of the disease and may also have systemic impact. Besides intense inflammation, these cytokines impair the function of the immune system. Both effects predispose to cancer onset, especially of those types associated with oncogenic herpesviruses reactivation, and may worsen the course of established cancers. In this Topical Collection, we would like to bring together articles covering different aspects of the possible impact of COVID-19 on cancer. In fact, people with cancer are among those at higher risk of complications if infected by SARS-CoV2, because their immune systems are already weakened by cancer and related treatment.

Dr. Gabriella D’Orazi
Dr. Mara Cirone
Collection Editors

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