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Article

Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19

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UMR 9020–UMR-S 1277–Canther–Cancer Heterogeneity, Plasticity and Resistance to Therapies, Institut de Recherche contre le Cancer de Lille, University Lille, CNRS, Inserm, CHU Lille, F-59000 Lille, France
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Department of Hematology, CHU Lille, F-59000 Lille, France
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Department of Intensive Care, CHU Lille, F-59000 Lille, France
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Department of Anesthesia and Critical Care, CHU Lille, F-59000 Lille, France
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Department of Emergency, CHU Lille, F-59000 Lille, France
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Department of Virology, CHU Lille, F-59000 Lille, France
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Department of Immunology, CHU Lille, F-59000 Lille, France
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Department of Biochemistry, CHU Lille, F-59000 Lille, France
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UMR1011-EGID, Pasteur Institute of Lille, University Lille, Inserm, CHU Lille, F-59000 Lille, France
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Department of Hemostasis, CHU Lille, F-59000 Lille, France
*
Author to whom correspondence should be addressed.
These authors equally contributed to this work.
Cancers 2020, 12(7), 1992; https://doi.org/10.3390/cancers12071992
Received: 30 June 2020 / Revised: 13 July 2020 / Accepted: 20 July 2020 / Published: 21 July 2020
(This article belongs to the Collection The Impact of COVID-19 Infection in Cancer)
Advanced age or preexisting comorbidities have been characterized as risk factors for severe coronavirus disease 2019 (COVID-19) cases requiring hospitalization and intensive care. In recent years, clonal hematopoiesis (CH) of indeterminate potential (CHIP) has emerged as a risk factor for chronic inflammatory background and subsequent aging-associated diseases. The purpose of this study was to identify biological factors (particularly leukocyte subtypes and inflammatory markers) associated with a risk of clinical deterioration (i.e., orotracheal intubation (OTI)) and to determine whether CH was likely to influence clinical and biological behavior in patients with severe COVID-19 requiring hospitalization. Here, we describe clinical and biological features, including the screening of CHIP mutants in a well-annotated cohort of 122 hospitalized patients with a laboratory-confirmed diagnosis of COVID-19 (55% requiring OTI). We showed that elevated white blood cell counts, especially neutrophils and high C-reactive protein (CRP) levels at admission, were associated with an increased requirement of OTI. We noticed a high prevalence of CH (25%, 38%, 56%, and 82% of patients aged <60 years, 60–70 years, 70–80 years, and >80 years) compared to a retrospective cohort of patients free of hematological malignancy explored with the same pipelines (10%, 21%, 37%, and 44%). However, the existence of CH did not significantly impact clinical outcome, including OTI or death, and did not correlate with other laboratory findings. View Full-Text
Keywords: SARS-CoV-2; COVID-19; clonal hematopoiesis; CHIP; sequencing; DNMT3A; TET2 SARS-CoV-2; COVID-19; clonal hematopoiesis; CHIP; sequencing; DNMT3A; TET2
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MDPI and ACS Style

Duployez, N.; Demonchy, J.; Berthon, C.; Goutay, J.; Caplan, M.; Moreau, A.-S.; Bignon, A.; Marceau-Renaut, A.; Garrigue, D.; Raczkiewicz, I.; Geffroy, S.; Bucci, M.; Alidjinou, K.; Demaret, J.; Labalette, M.; Brousseau, T.; Dupont, A.; Rauch, A.; Poissy, J.; Susen, S.; Preudhomme, C.; Quesnel, B., on behalf of the Lille Covid Research Network (LICORNE). Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19. Cancers 2020, 12, 1992. https://doi.org/10.3390/cancers12071992

AMA Style

Duployez N, Demonchy J, Berthon C, Goutay J, Caplan M, Moreau A-S, Bignon A, Marceau-Renaut A, Garrigue D, Raczkiewicz I, Geffroy S, Bucci M, Alidjinou K, Demaret J, Labalette M, Brousseau T, Dupont A, Rauch A, Poissy J, Susen S, Preudhomme C, Quesnel B on behalf of the Lille Covid Research Network (LICORNE). Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19. Cancers. 2020; 12(7):1992. https://doi.org/10.3390/cancers12071992

Chicago/Turabian Style

Duployez, Nicolas, Jordane Demonchy, Céline Berthon, Julien Goutay, Morgan Caplan, Anne-Sophie Moreau, Anne Bignon, Alice Marceau-Renaut, Delphine Garrigue, Imelda Raczkiewicz, Sandrine Geffroy, Maxime Bucci, Kazali Alidjinou, Julie Demaret, Myriam Labalette, Thierry Brousseau, Annabelle Dupont, Antoine Rauch, Julien Poissy, Sophie Susen, Claude Preudhomme, and Bruno Quesnel on behalf of the Lille Covid Research Network (LICORNE). 2020. "Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19" Cancers 12, no. 7: 1992. https://doi.org/10.3390/cancers12071992

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