The Hippo tumour suppressor pathway has emerged as a critical regulator of tissue growth through controlling cellular processes such as cell proliferation, death, differentiation and stemness. Traditionally, the core cassette of the Hippo pathway inc...
Due to the high manufacturing cost of memristors, an equivalent emulator has been employed as one of the mainstream approaches of memristor research. A threshold-type memristor emulator based on negative differential resistance (NDR) characteristics...
Noise (un-important) alerts are generally considered a major challenge in intrusion detection systems/sensors because they require more analysts to review and may cause disruption to systems that are shut down to avoid the consequences of a compromis...
Diabetic retinopathy (DR), a major complication of diabetes, is driven by chronic inflammation in which retinal microglial cells play a central role. The Hippo pathway kinases NDR1/2 regulate macrophage function, but their role in microglia and DR re...
Negative differential resistance (NDR) is inherent in many electronic devices, in which, over a specific voltage range, the current decreases with increasing voltage. Semiconductor structures with NDR have several unique properties that stimulate the...
This paper focuses on the Negative Differential Resistance (NDR) we observed on organic light-emitting diodes (OLEDs) using [Pt(II)(tetra-tert-butylSalophen)] as host, since this Pt(II) complex displays a deep-red emission (λmax = 660 nm). Ele...
The MOR (Morphogenesis-related NDR kinase) signaling network, initially identified in yeast, exhibits evolutionary conservation across eukaryotes and plays indispensable roles in the normal growth and development of these organisms. However, the func...
Although Orthogonal Frequency Division Multiplexing (OFDM) technology is still the key transmission waveform technology in 5G, traditional channel estimation algorithms are no longer sufficient for the high-speed multipath time-varying channels faced...
In the future, climate change will induce even more severe hurricanes. Not only should these be better understood, but there is also a necessity to improve the assessment of their impacts. Flooding is one of the most common powerful impacts of these...
The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular...
The transport properties of molecular devices based on carbon chains are systematically investigated using a combination of non-equilibrium Green’s function (NEGF) and density functional theory (DFT) first-principle methods. In single-carbon-ch...
This study develops a low-energy, high-precision nanoporous silicon process technology combining electrochemical etching with multi-wavelength laser irradiation and ultrasonic vibration to precisely control the size, porosity, and distribution of the...
Resistive switching memories are among the emerging next-generation technologies that are possible candidates for in-memory and neuromorphic computing. In this report, resistive memory-switching behavior in solution-processed trans, trans-1,4-bis-(2-...
The tomato Sw-5b gene confers resistance to tomato spotted wilt virus (TSWV) and encodes a nucleotide-binding leucine-rich repeat (NLR) protein with an N-terminal Solanaceae-specific domain (SD). Although our understanding of how Sw-5b recognizes the...
Nucleosome sequence composition is closely associated with gene expression. The nucleosome-depleted region (NDR) within the transcriptional regulatory region of S. cerevisiae genes plays a crucial role in the regulation of gene expression. To investi...
Neurodevelopmental regression (NDR) is an enigmatic event associated with autism spectrum disorder (ASD) during which a child loses previously acquired skills and develops ASD symptoms. In some, a trigger which precedes the NDR event, such as a fever...
15 April 2021
The national dose registry (NDR) contains essential information to help protect radiation workers from radiation-related health risks and to facilitate epidemiological studies. However, direct validation of the reported doses has not been considered....
The utilization of Effective Microorganisms (EMs) for lake restoration represents a sustainable approach to enhancing water quality and rebalancing the ecology of aquatic ecosystems. The primary objective of this study was to evaluate the effects of...
VO2 is the prototype material for insulator–metal transition (IMT). Its transition at TIMT = 340 K is fast and consists of a large resistance jump (up to approximately five orders of magnitude), a large change in its optical properties in the visible...
As we increasingly use advanced technology nodes to design integrated circuits (ICs), physical designers and electronic design automation (EDA) providers are facing multiple challenges, firstly, to honor all physical constraints coming with cutting-e...
25 February 2024
Kinases play crucial roles in the pathophysiology of retinal degenerative diseases. These diseases, such as diabetic retinopathy, age-related macular degeneration, glaucoma, and retinitis pigmentosa, are characterized by progressive degeneration of r...
In this study, the negative differential resistance (NDR) phenomenon in two-terminal devices composed of pyrogallol-formaldehyde/ZrO2 composite materials is investigated. It is demonstrated that the NDR is caused by electrothermal effects, which can...
9 July 2022
This study aimed to estimate the level of underestimation of National Dose Registry (NDR) doses based on the workers’ dosimeter wearing compliance. In 2021, a nationwide survey of Korean medical radiation workers was conducted. A total of 989 m...
Electronic devices and circuits with negative differential resistance (NDR) are widely used in oscillators, memory devices, frequency multipliers, mixers, etc. Such devices and circuits usually have an N-, S-, or Λ-type current-voltage charact...
A resonant tunneling electronic circuit (RTEC) with high and multiple peak-to-valley current density ratios (PVCDRs) exhibited in the negative differential resistance (NDR) curve has been proposed in this research. The PVCDR values in simulating rese...
Almost half of patients show no primary or secondary response to monoclonal anti-tumor necrosis factor α (anti-TNF) antibody treatment for inflammatory bowel disease (IBD). Thus, the exact mechanisms of a non-durable response (NDR) remain inade...
Land Use and Land Cover Change (LULCCs) shapes catchment dynamics and is a key driver of hydrological risks, affecting hydrological responses as vegetated land is replaced with urban developments and cultivated land. The resultant hydrological risks...
The aim of the study was to compare telomere lengths and circulating proteasome concentrations in patients with different stages of diabetic retinopathy and type 1 diabetes in Latvia and Lithuania. Methods. Patients with no diabetic retinopathy and w...
We report on photo-detectors consisting of an optical waveguide that incorporates a resonant tunneling diode (RTD). Operating at wavelengths around 1.55 μm in the optical communications C band we achieve maximum sensitivities of around 0.29 A/W which...
The lack of transparency in many AI systems continues to hinder their adoption in critical domains such as healthcare, finance, and autonomous systems. While recent explainable AI (XAI) methods—particularly those leveraging large language model...
We explored differences in the DNA methylation statuses of PSMA6, PSMB5, HIF1A, and KEAP1 gene promoter regions in patients with type 1 diabetes and different diabetic retinopathy (DR) stages. Study subjects included individuals with no DR (NDR, n =...
Advanced glycation end products (AGEs) and carotenoids, the major prooxidants and antioxidants in vivo, respectively, are thought to be associated with diabetes mellitus (DM). To estimate AGEs and carotenoid levels simultaneously in patients with DM,...
This article investigates the snow albedo changes in Colombian tropical glaciers, namely, Sierra Nevada de Santa Marta (SNSM), Sierra Nevada del Cocuy (NSC), Nevado del Ruíz (NDR), Nevado Santa Isabel (NDS), Nevado del Tolima (NDT), and Nevado...
We investigated whether the response to anti-tumor necrosis factor (anti-TNF) treatment varied according to inflammatory tissue characteristics in Crohn’s disease (CD). Bulk RNA sequencing (RNA-seq) data were obtained from inflamed and non-infl...
Despite the high prevalence of epilepsy in individuals with autism spectrum disorder (ASD), there is little information regarding whether seizure characteristics and treatment effectiveness change across age. Using an online survey, seizure character...
Based on two-dimensional green phosphorene, we designed two molecular electronic devices with zigzag (Type 1) and whisker-like (Type 2) configurations. By combining density functional theory (DFT) and non-equilibrium Green’s function (NEGF), we...
I would like to thank Fluegge and Fluegge for their comments on our study which identified air pollution and maximum temperature as potential environmental factors associated with neurodevelopmental regression (NDR) in children with autism spectrum d...
Memristive systems can provide a novel strategy to conquer the von Neumann bottleneck by evaluating information where data are located in situ. To meet the rising of artificial neural network (ANN) demand, the implementation of memristor arrays capab...
In this paper, we present circuit solutions based on a switch element with the S-type I–V characteristic implemented using the classic FitzHugh–Nagumo and FitzHugh–Rinzel models. Using the proposed simplified electrical circuits all...
While the first part of this study took a detailed look at the properties, defects and classification of brown diamonds with deformation-related (DR) brown color and compared them to pink to purple to red diamonds, this second part covers diamonds wi...
Two-dimensional (2D) materials promise advances in electronic devices beyond Moore’s scaling law through extended functionality, such as non-monotonic dependence of device parameters on input parameters. However, the robustness and performance...
The growing mismatch between ecosystem service (ES) supply and demand underscores the importance of thoroughly understanding their spatiotemporal patterns and key drivers to promote ecological civilization and sustainable development at the regional...
Background and Objectives: The purpose of the study was to investigate the role of adrenaline (ADR), noradrenaline (NDR), and cortisol in the pathogenesis of the analgesic potency, duration, and epilepsy-like toxic effect of meperidine. Materials and...
Autism Spectrum Disorder (ASD) is associated with many variations in metabolism, but the ex-act correlates of these metabolic disturbances with behavior and development and their links to other core metabolic disruptions are understudied. In this stu...
Cellular DNA is packaged into chromatin, which is composed of regularly-spaced nucleosomes with occasional gaps corresponding to active regulatory elements, such as promoters and enhancers, called nucleosome-depleted regions (NDRs). This chromatin or...
The pathogenesis of diabetic retinopathy is still challenging, with recent evidence proving the key role of inflammation in the damage of the retinal neurovascular unit. This study aims to investigate the predictive value of the neutrophil-to-lymphoc...
This paper has studied the electronic properties of multi-diluted magnetic semiconductor (DMS) layers Ga(1 − x)MnxAs interposed between nonmagnetic GaAs layers. The asymmetry of confining potential on the transmission coefficient by tuning the...
The Niger Delta Region is the largest river delta in Africa and features the fifth largest mangrove forest on Earth. It provides numerous ecosystem services to the local populations and holds a wealth of biodiversity. However, due to the oil and gas...
The aim of this study was to analyze the possible nephroprotective effect of 3’,4’-dihydroxyphenylglycol (DHPG), a polyphenolic compound of extra virgin olive oil (EVOO), on renal lesions in an experimental model of type 1 diabetes. Rats...
Modeling ecosystem services (ESs) intrinsically involves the use of spatial and temporal data. Correct estimates of ecosystem services are inherently dependent upon the scale (resolution and extent) of the input spatial data. Sensitivity of modeling...
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