Next Article in Journal
An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress
Next Article in Special Issue
Regulation of TEAD Transcription Factors in Cancer Biology
Previous Article in Journal
Spatiotemporal Regulation of Rho GTPases in Neuronal Migration
Previous Article in Special Issue
The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling
Open AccessFeature PaperReview

MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer

1
Vocational School of Health Services, Bingol University, 12000 Bingol, Turkey
2
UCL Cancer Institute, University College London, WC1E 6BT, London, United Kingdom
*
Author to whom correspondence should be addressed.
Cells 2019, 8(6), 569; https://doi.org/10.3390/cells8060569
Received: 1 May 2019 / Revised: 3 June 2019 / Accepted: 4 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue Disease and the Hippo Pathway: Cellular and Molecular Mechanisms)
The family of MOBs (monopolar spindle-one-binder proteins) is highly conserved in the eukaryotic kingdom. MOBs represent globular scaffold proteins without any known enzymatic activities. They can act as signal transducers in essential intracellular pathways. MOBs have diverse cancer-associated cellular functions through regulatory interactions with members of the NDR/LATS kinase family. By forming additional complexes with serine/threonine protein kinases of the germinal centre kinase families, other enzymes and scaffolding factors, MOBs appear to be linked to an even broader disease spectrum. Here, we review our current understanding of this emerging protein family, with emphases on post-translational modifications, protein-protein interactions, and cellular processes that are possibly linked to cancer and other diseases. In particular, we summarise the roles of MOBs as core components of the Hippo tissue growth and regeneration pathway. View Full-Text
Keywords: Mps one binder; Hippo pathway; protein kinase; signal transduction; phosphorylation; protein-protein interactions; structure biology; STK38; NDR; LATS; MST; STRIPAK Mps one binder; Hippo pathway; protein kinase; signal transduction; phosphorylation; protein-protein interactions; structure biology; STK38; NDR; LATS; MST; STRIPAK
Show Figures

Figure 1

MDPI and ACS Style

Gundogdu, R.; Hergovich, A. MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer. Cells 2019, 8, 569.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop