Underwater vehicles must operate efficiently within the limits of their onboard resources, and travel time is a primary operational objective for extending submerged endurance and range. Ocean currents significantly affect vehicle motion and travel t...
Tracking cell death in vivo can enable a better understanding of the biological mechanisms underlying tissue homeostasis and disease. Unfortunately, existing cell death labeling methods lack compatibility with in vivo applications or suffer from low...
The dysfunction of α and β cells in pancreatic islets can lead to diabetes. Many questions remain on the subcellular organization of islet cells during the progression of disease. Existing three-dimensional cellular mapping approaches face...
Cumulative reports of psychiatric and neurological outcomes due to synthetic cathinones continue to raise public concern. However, the understanding of the neurotoxic mechanism of action is still poorly understood, particularly for the under-explored...
Background: The histopathological assessment is critical in the comprehensive treatment process for patients diagnosed with oral squamous cell carcinoma (OSCC). A detailed and precise specimen characterization is essential to facilitate effective sur...
3D city models are being extensively used in applications such as evacuation scenarios and energy consumption estimation. The main standard for 3D city models is the CityGML data model which can be encoded through the CityJSON data format. CityGML an...
We construct a new volume preserving map from the unit ball
In a situation where cities are increasingly being developed vertically and complexly, a novel approach for analyzing vertical urban functional patterns is proposed. For this purpose, a multi-dimensional GDC (Geo Data Cube) consisting of spatial and...
Actinomycin D (ActD) is an FDA-approved NCI oncology drug that specifically targets and downregulates stem cell transcription factors, which leads to a depletion of stem cells within the tumor bulk. Recently, our research group demonstrated the impor...
Most platforms used for the molecular reconstruction of the tumor–immune microenvironment (TIME) of a solid tumor fail to explore the spatial context of the three-dimensional (3D) space of the tumor at a single-cell resolution, and thus lack in...
Raman mapping is becoming a very useful tool in investigating cells and cellular components, as well as bioactive molecules intracellularly. In this study, we have encapsulated beta-carotene using a layer-by-layer technique, as a way to enhance its s...
In this work, a 2-D gridded air pollution map with a high resolution of 50 × 50 m2 was proposed to help the exposure assessment studies focusing on the association between air pollutants and their health effects. To establish a reliable air pol...
The locations of transcription and translation of mRNA in eukaryotic cells are spatially separated by the nuclear envelope (NE). Plenty of nuclear pore complexes (NPCs) embedded in the NE function as the major gateway for the export of transcribed mR...
Automated three-dimensional (3D) mapping with a survey-grade terrestrial laser scanner (TLS) is the canonical instance of robotic stop-and-scan light detection and ranging (LiDAR) mapping: the mobile platform must remain stationary for minutes per sc...
Background: Mycobacterium avium subsp. paratuberculosis (MAP) is the causal agent of paratuberculosis. This pathogen is able to survive adverse environmental conditions, including the pasteurization process. Copper, a well-studied metal, is considere...
This paper introduces a novel protocol for managing low altitude 3D aeronautical chart data to address the unique navigational challenges and collision risks associated with populated urban environments. Based on the Open Geospatial Consortium (OGC)...
Background: Vitamin D plays a vital role in modulating both innate and adaptive immune systems. Therefore, vitamin D deficiency has been associated with higher levels of autoimmune response and increased susceptibility to infections. CYP27B1 encodes...
The present studies were conducted to evaluate key serum proteins and other components that mediate anchorage-independent growth (3-D growth) of LNCaP prostate cancer cells as spheroids. The cells were cultured on ultra-low attachment plates in the a...
Indoor mobile robots equipped with low-cost and sparse sensors often suffer from limited vertical perception and dynamic residual artifacts in the final map. This paper presents a lightweight 2.5D simultaneous localization and mapping (SLAM) framewor...
Type 2 diabetes (T2D) is a complex disorder that is caused by a combination of genetic, epigenetic, and environmental factors. High-throughput approaches have opened a new avenue toward a better understanding of the molecular bases of T2D. A genome-w...
Fast and accurate obstacle detection is essential for accurate perception of mobile vehicles’ environment. Because point clouds sensed by light detection and ranging (LiDAR) sensors are sparse and unstructured, traditional obstacle clustering o...
Reaction-diffusion models have been proposed for decades to capture the growth of gliomas. Nevertheless, these models require an initial condition: the tumor cell density distribution over the whole brain at diagnosis time. Several works have propose...
Background/Objectives: Pancreatic cancer (PC) is the seventh leading cause of cancer-related deaths worldwide, with its incidence rising each year. Despite its relatively low incidence, the aggressiveness of pancreatic cancer results in high mortalit...
Given the challenging environmental issues in the energy sector, the importance of strategic research and development (R&D) planning has been emphasized to manage a turbulent business situation. This study aims to propose a methodology for explor...
Altered biophysical properties of cancer cells and of their microenvironment contribute to cancer progression. While the relationship between microenvironmental stiffness and cancer cell mechanical properties and responses has been previously studied...
Our objective was to describe the electrophysiological properties of the extracellular action potential (AP) picked up through microelectrode recordings (MERs). Five patients were operated under general anesthesia for centromedian deep brain stimulat...
Three-dimensional (3D) point analysis and visualization is one of the most effective methods of point cluster detection and segmentation in geospatial datasets. However, serious scattering and clotting characteristics interfere with the visual detect...
Although autologous nerve grafting remains the gold standard treatment for peripheral nerve injuries, alternative methods such as development of nerve guidance conduits have since emerged and evolved to counter the many disadvantages of nerve graftin...
Polysaccharides (CDP-D2-N1) were extracted from Cistanche deserticola and used as an immunomodulatory substance to control inflammation and cytokines. This article chose LPS-induced inflammation model in RAW264.7 as the study subject and discloses th...
The contribution of genetics to the development of gut-related autoimmune diseases such as celiac disease (CeD) and inflammatory bowel diseases (IBDs) is well-established, especially in immune cells, but pinpointing the significance of genetic varian...
GNSS-based InBSAR can be used for 3D deformation monitoring due to its remote sensing capability, simultaneous use of multiple transmitters of opportunity, and high-accuracy potential. Mature GB-SAR and D-GNSS measurements can be used for comprehensi...
In this paper, an Efficient Method for PHotovoltaic Arrays Study through Infrared Scanning (EMPHASIS) is presented; it is a fast, simple, and trustworthy cell-level diagnosis method for commercial photovoltaic (PV) panels. EMPHASIS processes temperat...
Peptide-based hydrogels were shown to serve as good matrices for 3D cell culture and to be applied in the field of regenerative medicine. The study of the cell-matrix interaction is important for the understanding of cell attachment, proliferation, a...
The phosphoinositide 3-kinase catalytic subunit p110δ (PI3Kδ) gene maps to a human inflammatory bowel diseases (IBD) susceptibility locus, and genetic deletion of PI3Kδ signaling causes spontaneous colitis in mice. However, little i...
We describe an approach to non-invasively map spatiotemporal biochemical and physiological changes in 3D cell culture using Forster Resonance Energy Transfer (FRET) biosensors expressed in tumour spheroids. In particular, we present an improved Adeno...
Glioblastoma multiforme (grade IV glioma) is characterized by a high invasive potential, making surgical intervention extremely challenging and patient survival very limited. Current pharmacological approaches show, at best, slight improvements in th...
Organ-on-chips and scaffolds for tissue engineering are vital assay tools for pre-clinical testing and prediction of human response to drugs and toxins, while providing an ethical sound replacement for animal testing. A success criterion for these mo...
Bok choy (Brassica rapa var. chinensis) experiences rapid postharvest quality decline, primarily due to water loss. This study aims to evaluate the effect of H2-modified atmosphere packaging (MAP; containing 0.01%, 0.1%, and 1% H2) on extending the s...
Visual Simultaneous Localization and Mapping (SLAM) approaches have achieved a major breakthrough in recent years. This paper presents a new monocular visual odometry algorithm able to localize in 3D a robot or a camera inside an unknown environment...
Vitamin D has been shown to improve immunity as well as vascular function. We investigated the effect of cholecalciferol on T-cell phenotype in cultured peripheral blood mononuclear cells (PBMCs) from twenty vitamin D-deficient, non-diabetic chronic...
With both computational complexity and storage space bounded by a small constant, greedy routing is recognized as an appealing approach to support scalable routing in wireless sensor networks. However, significant challenges have been encountered in...
Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity. Herein, we have depicted the profile of CD8+ and CD4+ T ce...
Conventional two-dimensional (2D) cell cultures are grown on rigid plastic substrates with unrealistic concentration gradients of O2, nutrients, and treatment agents. More importantly, 2D cultures lack cell–cell and cell–extracellular mat...
Superior fiber quality is one of the most important objectives in cotton breeding. To detect the genetic basis underlying fiber quality, an F2 population containing 413 plants was constructed by crossing Jifeng 914 and Jifeng 173, both of which have...
Various types of 2D organic–inorganic perovskite solar cells have been developed and investigated due to better electron transport behavior and environmental stability. Controlling the formation of phases in the 2D perovskite films has been con...
Polo-like kinase 1, an important enzyme with diverse biological actions in cell mitosis, is a promising target for developing novel anticancer drugs. A combined molecular docking, structure-based pharmacophore modeling and three-dimensional quantitat...
A series of mono-pyrrolo[2,3-d]pyrimidines 4a–4k, unsymmetrical bis-purine isosteres 5a–5e and symmetrical bis-pyrrolo[2,3-d]pyrimidines 6a and 6b connected via di(1,2,3-triazolyl)phenyl linker were synthesized by click chemistry. Whereas mono- 4g an...
In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium and phosphorus absorption, as well as bone mineralization of vitamin D, the population-based association between low vitamin D status and increased cancer...
Electrical impedance spectroscopy (EIS) is widely recognized as a powerful tool in biomedical research. For example, it allows detection and monitoring of diseases, measuring of cell density in bioreactors, and characterizing the permeability of tigh...
There is emerging evidence of an association between epigenetic modifications, glycemic control and atherosclerosis risk. In this study, we mapped genome-wide epigenetic changes in patients with type 2 diabetes (T2D) and advanced atherosclerotic dise...
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