Special Issue "Vitamin D and Human Health"
Deadline for manuscript submissions: closed (15 June 2018).
A printed edition of this Special Issue is available here.
Over the past few decades, researchers have gathered data demonstrating that vitamin D and its metabolites possess activities far beyond classic regulation of calcium–phosphate homeostasis. It has been demonstrated that vitamin D is essential for proper function of musculoskeletal, cardiovascular, nervous, and immune systems. Furthermore, vitamin D and its analogs were shown to regulate proliferation and differentiation of keratinocyte, immune cells and numerous cancer-derived cells, both in vivo and in vitro. On the other hand population base studies have provided evidence that global vitamin D deficiency is correlated to the occurrence and aggravation of symptoms of skeletal, cardiovascular autoimmune and skin disease; infections; metabolic and cognitive disorders; multiple types of cancers, as well as overall mortality. Most importantly, proper vitamin D supplementation is known to have beneficial effects on our health and is essential for prevention, as well as regression of multiple diseases of civilization. Having in mind extra-skeletal effects of vitamin D, recent guidelines have suggested an increase in a target 25(OH)D concentration from 20 ng/mL (50 nmol/L) to 30 ng/mL (75 nmol/L), what requires higher daily vitamin D supplementation (up to 2000 IU for healthy adults). Finally, therapeutic use of high doses of vitamin D, as well as its low calcemic analogs is currently under intensive investigation. However, in order to fully understand the intracellular mechanisms activated by vitamin D, as well pleiotropic effects of vitamin D on human health and disease, further studies are still required.
This Special Issue gives insight in the evolving field of vitamin D regarding its mechanisms of action, deficiency, supplementation, health benefits, and clinical applications.
Prof. Michal Zmijewski
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- vitamin D
- analogs of vitamin D
- vitamin D deficiency
- vitamin D activity and metabolism
- extra-skeletal effects
- therapy and prevention