Castrate-resistant prostate cancer (CRPC) is challenging to treat with the androgen receptor (AR), the main target and key focus of resistance. Understanding the mechanisms of AR interaction with co-regulators will identify new therapeutic targets to...
Transcription factors of the APETALA 2/Ethylene Response Factor (AP2/ERF)-family have been implicated in diverse processes during development, stress acclimation and retrograde signaling. Fifty-three leaf-expressed AP2/ERFs were screened for their t...
The selection of an adequate response reduction factor (R) in the seismic design of a reinforced concrete building is critical to the building’s seismic response. To construct a robust structure, the R factor should be chosen based on the build...
A multi-step phosphorelay system is the main conduit of cytokinin signal transduction. However, several groups of additional factors that also play a role in this signaling pathway have been found—among them the Cytokinin Response Factors (CRFs...
The wind-induced responses of tall buildings are stochastic processes, and the peak factor is an important parameter to evaluate the extreme value of the wind-induced response in wind-resistant design. The existing research on the peak factor mainly...
Auxin response factor (ARF) is a plant-specific transcription factor that responds to changes in auxin levels, regulating various biological processes in plants such as flower development, senescence, lateral root formation, stress response, and seco...
The response modification factor R is a fundamental parameter in seismic design, linking the elastic demand expected under strong ground motion to the reduced forces used in practice. It reflects the capacity of well-detailed structures to dissipate...
The NAC (NAM-ATAF1/2-CUC) transcription factor family is one of the largest plant-specific transcription factor families, playing an important role in plant growth and development and abiotic stress response. As a short-rotation woody plant, Salix in...
During tumor growth, angiogenesis is required to ensure oxygen and nutrient transport to the tumor. Vascular endothelial growth factor (VEGF) is the major inducer of angiogenesis and appears to be a key modulator of the anti-tumor immune response. In...
Auxin response factors (ARFs) are important plant transcription factors that are differentially expressed in response to auxin and various abiotic stresses. ARFs play important roles in mediating plant growth and stress responses; however, these fact...
Crypto wallets store and protect the private keys needed to sign transactions for crypto currencies; they are secured by multi-factor authentication schemes. However, the loss of a wallet, or a dysfunctional factor of authentication, can be catastrop...
Auxin response factors (ARFs) are a pivotal class of transcription factors that mediate auxin signaling, playing critical roles in plant growth, development, and stress adaptation. Watermelon (Citrullus lanatus) is an economically important cucurbit...
6 October 2022
The Dark Factor of Personality (D) describes the common core of dark traits and is a stable indicator for socially aversive behaviors. This study investigated the psychometric properties of the Chinese version of the Dark Factor of Personality Scale...
The lack of effective anti-fibrotic agents remains a significant unmet need in the treatment of intestinal fibrosis, a condition largely driven by transforming growth factor-β1 (TGF-β1)-mediated myofibroblast activation. Phosphodiesterase 4...
Background and aim: Mental stress represents a pivotal factor in cardiovascular diseases. The mechanism by which stress produces its deleterious ischemic effects is still under study but some of the most explored pathways are inflammation, endothelia...
This study examined the role of Geographic Information Systems (GIS) in municipal responses to the COVID-19 pandemic in Israel. A structured survey of officials from 130 municipalities was conducted, with a focus on the 87 municipalities that utilize...
This paper presents a study of the frequency response and the scale-factor of a tuning fork micro-gyroscope operating at atmospheric pressure in the presence of an interference sense mode by utilizing the approximate transfer function. The optimal de...
The fastest growing demographic in the U.S. at the present time is those aged 65 years and older. Accompanying advancing age are a myriad of physiological changes in which reserve capacity is diminished and homeostatic control attenuates. One facet o...
Auxin response factors (ARFs) are a transcription factor family that regulates the expression of auxin phase-responsive genes. Here, we performed a genome-wide investigation of the tetraploid blueberry (Vaccinium corymbosum cv. ‘Draper’) genome seque...
Nitrite toxicity poses a significant threat to aquatic organisms, including largemouth bass (LMB) and Micropterus salmoides. This study aimed to elucidate the role of bZIP transcription factors in mediating the molecular responses to nitrite stress i...
We propose a methodology to estimate the yield response factor (i.e., the slope of the water-yield function) under local conditions for a given crop, weather, sowing date, and management at each growth stage using AquaCrop-OS. The methodology was app...
Nitraria sibirica is a shrub that can survive in extreme drought environments. The auxin-response factors (ARFs) are a class of transcription factors that are widely involved in plant growth and development, as well as in the regulation of stress res...
Zinc finger-homeodomain (ZF-HD) transcription factors are a unique class that only exist in plants and are essential for plant growth and development, various stress responses, and quality formation and regulation. In recent years, an increasing numb...
The heat flow meter method (HFM) is one of the most-used methods for the in situ measurement of wall thermal resistance. However, the standard HFM method has some issues: it is challenging to balance simplicity and accuracy in data analysis and the m...
Background: Alternative splicing is an important mechanism of transcriptomic and proteomic diversity and is progressively involved in cardiovascular disease (CVD) pathogenesis. Serum response factor (SRF), a critical transcription factor in cardiac d...
Auxin participates in various physiological and molecular response-related developmental processes and is a pivotal hormone that regulates phenotypic formation in plants. Auxin response factors (ARFs) are vital transcription factors that mediate down...
Astronauts are exposed to considerable doses of space radiation during long-term space missions. As complete shielding of the highly energetic particles is impracticable, the cellular response to space-relevant radiation qualities has to be understoo...
Caucasian clover (Trifolium ambiguum M. Bieb.) is an excellent perennial plant in the legume family Fabaceae, with a well-developed rhizome and strong clonal growth. Auxin is one of the most important phytohormones in plants and plays an important ro...
To demonstrate the value of hypoxia-inducible factor-1α (HIF-1α) in predicting response in patients with breast cancer receiving standard neoadjuvant chemotherapy (NAC). Methods: Ninety-five women enrolled in two prospective studies under...
WRKY transcription factors (TFs) have been reported to respond to biotic and abiotic stresses and regulate plant growth and development. However, the molecular mechanisms of WRKY TFs involved in drought stress and regulating plant height in rice rema...
OsARF1 is the first full-length member of auxin response factor (ARF) gene family to be cloned from monocot plant. Using quantitative RT-PCR this study found that, the transcript abundance of OsARF1 was significantly higher in embryonic tissues than...
Auxin response factors (ARFs) are critical components of the auxin signaling pathway, and are involved in diverse plant biological processes. However, ARF genes have not been investigated in flax (Linum usitatissimum L.), an important oilseed and fib...
As the key transcription factors regulating auxin responsive genes expression, auxin response factors (ARFs) play critical roles in diverse aspects of plant growth and development. Betula pendula is a valuable ornamental tree, and the information on...
Mitochondria are important organelles in eukaryotes and are involved in various metabolic processes. Mitochondrial proteotoxic stress triggers the mitochondrial unfolded protein response (UPRmt) to restore mitochondrial protein homeostasis and mainta...
Nuclear Factor-Y (NF-Y) transcription factors play vital roles in plant abiotic stress response. Here, the NF-Y family in Brassica napus, which is hyper-sensitive to nitrogen (N) deprivation, was comprehensively identified and systematically characte...
The low-carbon transition of the power sector is fundamental to achieving “Dual Carbon” goals, where demand-side management plays an increasingly vital role in transforming flexible loads into renewable energy accommodation and active emi...
Auxin is a key regulator that virtually controls almost every aspect of plant growth and development throughout its life cycle. As the major components of auxin signaling, auxin response factors (ARFs) play crucial roles in various processes of plant...
Soil salinization is one of the major abiotic stresses that influences agricultural production and the environment. Auxin response factors (ARFs) are key components of the auxin signal transduction pathway, while their role in wheat salt stress respo...
Serum response factor (SRF) controls the expression of muscle contraction and motility genes in mural cells (MCs) of the vasculature. In the retina, MC-SRF is important for correct angiogenesis during development and the continuing maintenance of the...
Aux/IAA and auxin response transcription factor (ARF) genes are key regulators of auxin responses in plants. A total of 25 MtIAA and 40 MtARF genes were identified based on the latest updated Medicago truncatula reference genome sequence. They were c...
Auxin response factors (ARFs) are essential transcription factors in plants that play an irreplaceable role in controlling the expression of auxin response genes and participating in plant growth and stress. The ARF gene family has been found in Arab...
The bHLH (basic helix–loop–helix) transcription factors function as crucial regulators in numerous biological processes including abiotic stress responses and plant development. According to our RNA-seq analysis of tomato seedlings under...
Phytochrome-interacting factor (PIF) is a subfamily of the basic helix–loop–helix (bHLH) transcription factors (TFs) and plays key roles in plant responses to diverse biotic and abiotic stresses. In this work, a PIF gene named CaPIF7a was...
Within the canonical auxin signaling pathway, Auxin Response Factors (ARFs) are transcriptionally repressed by AUX/IAA proteins under low auxin conditions, and this repression is alleviated as auxin concentrations increase. By contrast, ARF3 function...
Background: Auxin, a plant hormone, plays diverse roles in the modulation of plant growth and development. The transport and signal transduction of auxin are regulated by various factors involved in shaping plant morphology and responding to external...
The accurate quantification of crop water use or evapotranspiration (ET) under water and salt stress is needed for efficient water management and precision irrigation in water scarce regions. However, few studies were examined on alfalfa water use an...
Fungal secondary metabolites play important roles not only in fungal ecology but also in humans living as beneficial medicine or harmful toxins. In filamentous fungi, bZIP-type transcription factors (TFs) are associated with the proteins involved in...
Trihelix transcription factors play a role in plant growth, development and various stress responses. Here, we identified 41 trihelix family genes in the rice genome. These OsMSLs (Myb/SANT-LIKE) were located on twelve chromosomes. Synteny analysis i...
The most prominent treatment for the serious cases of Crohn’s disease (CD) are biological tumour necrosis factor (TNF) inhibitors. Unfortunately, therapy nonresponse is still a serious issue in ~1/3 of CD patients. Accurate prediction of respon...
The design innovation of high-strength steel frames paired with D-eccentric bracing exhibits remarkable resistance to plastic deformation during seismic events. This method strategically combines regular steel connections (with yield strengths below...
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