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8,082 Results Found

  • Article
  • Open Access
1,208 Views
11 Pages

28 June 2024

This paper investigates robust constrained cooperative control for multiple trains, taking into account disturbances, velocity and control input constraints, and nonlinear operation resistances. A robust constrained cooperative control algorithm is e...

  • Article
  • Open Access
1 Citations
2,550 Views
19 Pages

21 April 2022

This paper studies the distributed adaptive cooperative control of multiple urban rail trains with position output constraints and uncertain parameters. Based on an ordered set of trains running on the route, a dynamic multiple trains movement model...

  • Article
  • Open Access
2 Citations
2,166 Views
16 Pages

5 September 2022

This paper studies the consensus control problem of multiple high-speed trains with nonlinear running resistance based on a distributed event-triggered control protocol. Firstly, the multiple high-speed trains are established as a multi-agent model w...

  • Article
  • Open Access
2 Citations
1,787 Views
16 Pages

9 April 2023

Parameter uncertainty is one of the key factors that affect the performance of train systems. In order to obtain good tracking and cooperation performances and to improve line utilization, this paper proposes a sliding mode surface-based cooperation...

  • Article
  • Open Access
1,246 Views
20 Pages

17 October 2024

In this paper, a novel multiple-model second-level adaptive failure compensation scheme is proposed for high-speed trains with unknown failures to achieve the desired system performance. High-speed train dynamics with unknown system parameters actuat...

  • Article
  • Open Access
2 Citations
2,167 Views
19 Pages

30 October 2023

In light of reducing train operation energy consumption while maintaining the passenger service level for creating sustainable urban rail transit systems, we address a non-parallel train timetabling problem considering regenerative braking energy uti...

  • Article
  • Open Access
762 Views
17 Pages

4 May 2025

This paper investigates the problem of ensuring the stable operation of multiple high-speed train systems under the threat of False Data Injection (FDI) attacks. Due to the wireless communication characteristics of railway networks, high-speed train...

  • Article
  • Open Access
7 Citations
3,101 Views
26 Pages

12 April 2022

The optimization of train plans is highly dependent on the space–time distribution of passenger demand in high-speed railway systems. A train plan usually needs to be implemented on multiple operation days, and obviously the amount and space&nd...

  • Review
  • Open Access
1 Citations
1,827 Views
14 Pages

Cues of Trained Immunity in Multiple Sclerosis Macrophages

  • Elisa Popa,
  • Hélène Cheval and
  • Violetta Zujovic

10 July 2025

Multiple sclerosis (MS) is a complex autoimmune disease with both genetic and environmental influences, yet its underlying mechanisms remain only partially understood. In this review, we compile evidence suggesting that trained immunity—a form...

  • Article
  • Open Access
49 Citations
12,693 Views
20 Pages

Electrical Modelling of a DC Railway System with Multiple Trains

  • Hammad Alnuman,
  • Daniel Gladwin and
  • Martin Foster

19 November 2018

Electrical modelling of rail tracks with multiple running trains is complex due to the difficulties in solving the power flow. The train positions, speed and acceleration are constantly varying resulting in a nonlinear system. In this work, a method...

  • Article
  • Open Access
299 Views
12 Pages

Can Exercise Training Improve the Quality of Life and Physical Function in Multiple Myeloma Patients?: Discussing the Progression of the Training Stimulus

  • Polyxeni Spiliopoulou,
  • Evangelos Eleutherakis-Papaiakovou,
  • Magdalini Migkou,
  • Nikolaos Kanellias,
  • Ioannis Ntanasis-Stathopoulos,
  • Panagiotis Malandrakis,
  • Foteini Theodorakakou,
  • Despina Fotiou,
  • Pantelis Rousakis and
  • Gerasimos Terzis
  • + 6 authors

4 February 2026

Background: Previous studies have reported no improvements in quality of life or physical function following exercise training in patients with multiple myeloma, without a clear explanation. The purpose of the present study was to examine the effects...

  • Article
  • Open Access
69 Citations
9,712 Views
11 Pages

Internet-Supported Physical Exercise Training for Persons with Multiple Sclerosis—A Randomised, Controlled Study

  • Alexander Tallner,
  • René Streber,
  • Christian Hentschke,
  • Marc Morgott,
  • Wolfgang Geidl,
  • Mathias Mäurer and
  • Klaus Pfeifer

30 September 2016

Physical exercise is effective in improving functional outcomes in persons with multiple sclerosis (pwMS). We evaluated the feasibility and effectiveness of internet-based exercise training (e-training) for pwMS on health-related quality of life (HrQ...

  • Systematic Review
  • Open Access
12 Citations
11,108 Views
16 Pages

Is Resistance Training an Option to Improve Functionality and Muscle Strength in Middle-Aged People with Multiple Sclerosis? A Systematic Review and Meta-Analysis

  • Javier Cano-Sánchez,
  • Agustín Aibar-Almazán,
  • Fidel Hita-Contreras,
  • Diego Fernando Afanador-Restrepo,
  • Antonio Martínez-Amat,
  • Alexander Achalandabaso-Ochoa and
  • María del Carmen Carcelén-Fraile

28 February 2024

Background: Currently, it is essential to adopt physical therapy strategies, such as resistance training, to enhance muscle strength and gait in middle-aged individuals (ages 45–65) suffering from Multiple Sclerosis. This is crucial in combatin...

  • Article
  • Open Access
6 Citations
3,800 Views
14 Pages

16 July 2020

While there are many data-driven diagnosis algorithms for fault isolation of complex systems, a new challenge arises in the case of multiple operating regimes. In this case, the diagnosis is usually carried out for each regime for better accuracy. Ho...

  • Article
  • Open Access
21 Citations
5,387 Views
19 Pages

17 December 2017

Energy consumption for multiple trains on the urban subway line is predominantly affected by the operation strategy. This paper proposed an energy-saving operation strategy for multiple trains, which is suitable for various line conditions and comple...

  • Systematic Review
  • Open Access
2 Citations
3,689 Views
18 Pages

Impact of Core Exercise Training on Gait and Exercise Capacity in People with Multiple Sclerosis: A Systematic Review

  • Juan Domingo Rodríguez-Martínez,
  • Paula Regalado-Cabello,
  • María Rodríguez-Montes,
  • Irene Cabrera-Martos,
  • Javier Martín-Nuñez and
  • Marie Carmen Valenza

1 May 2025

Multiple sclerosis is a prevalent neurodegenerative disease that significantly affects gait and exercise capacity. The core system is involved in providing sufficient spinal stability for dealing with stability demands. People with multiple sclerosis...

  • Article
  • Open Access
30 Citations
7,990 Views
13 Pages

Robot-Assisted Gait Training in Patients with Multiple Sclerosis: A Randomized Controlled Crossover Trial

  • Cristiano Sconza,
  • Francesco Negrini,
  • Berardo Di Matteo,
  • Alberto Borboni,
  • Gennaro Boccia,
  • Ignas Petrikonis,
  • Edgaras Stankevičius and
  • Roberto Casale

14 July 2021

Background and Objectives: Gait disorders represent one of the most disabling aspects in multiple sclerosis (MS) that strongly influence patient quality of life. The improvement of walking ability is a primary goal for rehabilitation treatment. The a...

  • Article
  • Open Access
14 Citations
5,241 Views
14 Pages

The ability to process goal-related visual information while ignoring goal-irrelevant information is essential for the human attention system. The study aimed to investigate how perceptual–cognitive performance was affected during high-intensity inte...

  • Article
  • Open Access
275 Views
16 Pages

Background/Objectives: Cognitive impairment and sleep disturbances are highly prevalent in individuals with multiple sclerosis (MS), particularly during middle age, and negatively affect functional independence and quality of life. Although physical...

  • Article
  • Open Access
2,655 Views
23 Pages

Four-Week Exoskeleton Gait Training on Balance and Mobility in Minimally Impaired Individuals with Multiple Sclerosis: A Pilot Study

  • Micaela Schmid,
  • Stefania Sozzi,
  • Bruna Maria Vittoria Guerra,
  • Caterina Cavallo,
  • Matteo Vandoni,
  • Alessandro Marco De Nunzio and
  • Stefano Ramat

Multiple Sclerosis (MS) is a chronic neurological disorder affecting the central nervous system that significantly impairs postural control and functional abilities. Robotic-assisted gait training mitigates this functional deterioration. This prelimi...

  • Article
  • Open Access
9 Citations
4,214 Views
14 Pages

19 August 2018

Electric multiple unit (EMU) trains’ high-level maintenance planning is a discrete problem in mathematics. The high-level maintenance process of the EMU trains consumes plenty of time. When the process is undertaken during peak periods of the p...

  • Article
  • Open Access
39 Citations
11,597 Views
8 Pages

22 February 2008

Range and velocity estimation of moving targets using conventional steppedfrequencypulse radar may suffer from the range-Doppler coupling and the phasewrapping. To overcome these problems, this paper presents a new radar waveform namedmultiple steppe...

  • Article
  • Open Access
18 Citations
4,512 Views
15 Pages

Rehabilitation Improves Mitochondrial Energetics in Progressive Multiple Sclerosis: The Significant Role of Robot-Assisted Gait Training and of the Personalized Intensity

  • Fabio Manfredini,
  • Sofia Straudi,
  • Nicola Lamberti,
  • Simone Patergnani,
  • Veronica Tisato,
  • Paola Secchiero,
  • Francesco Bernardi,
  • Nicole Ziliotto,
  • Giovanna Marchetti and
  • Paolo Pinton
  • + 2 authors

17 October 2020

Abnormal levels of pyruvate and lactate were reported in multiple sclerosis (MS). We studied the response of markers of mitochondrial function to rehabilitation in relation to type, intensity and endurance performance in severely disabled MS patients...

  • Systematic Review
  • Open Access
1 Citations
4,794 Views
20 Pages

7 November 2024

Background: Multiple sclerosis (MS) is an immune-mediated inflammatory disease that primarily targets the myelin of axons. Extremities are frequently affected, resulting in a negative impact on both activities of daily living (ADL) and quality of lif...

  • Article
  • Open Access
5 Citations
3,324 Views
14 Pages

Can Robotic Gait Training with End Effectors Improve Lower-Limb Functions in Patients Affected by Multiple Sclerosis? Results from a Retrospective Case–Control Study

  • Mirjam Bonanno,
  • Maria Grazia Maggio,
  • Laura Ciatto,
  • Rosaria De Luca,
  • Angelo Quartarone,
  • Angela Alibrandi and
  • Rocco Salvatore Calabrò

7 March 2024

Background: Multiple sclerosis (MS) is characterized as a neurodegenerative condition possibly triggered by autoimmune mechanisms, impacting the entire central nervous system. In this context, neurorehabilitation plays a crucial role in every phase o...

  • Article
  • Open Access
6 Citations
9,413 Views
10 Pages

Supervised Pelvic Floor Muscle Training Improves Sexual Function and Diminishes Sexual Distress in Women with Relapsing–Remitting Multiple Sclerosis: A Randomised Controlled Study

  • Athanasios Zachariou,
  • Athanasios Zikopoulos,
  • Vaia Sapouna,
  • Chara Skentou,
  • Aris Kaltsas,
  • Ioannis Giannakis,
  • Dimitrios Zachariou,
  • Fotios Dimitriadis,
  • Charalampos Mamoulakis and
  • Nikolaos Sofikitis
  • + 3 authors

12 January 2024

This study investigates the impact of pelvic floor muscle training (PFMT) on sexual function and distress in women with multiple sclerosis (MS), a prevalent chronic nervous system disorder associated with sexual dysfunction. This study’s primar...

  • Article
  • Open Access
27 Citations
7,344 Views
29 Pages

17 September 2021

This paper presents a simulation-based analysis of hybrid and plug-in hybrid propulsion system concepts for diesel-electric multiple unit regional railway vehicles. These alternative concepts primarily aim to remove emissions in terminal stops with l...

  • Article
  • Open Access
299 Views
23 Pages

Feasibility and Pre–Post Changes Associated with a 12-Week Treadmill Walking Training Programme on Walking Performance, Physical Function, Fatigue, and Quality of Life in People with Multiple Sclerosis: A Single-Arm Pilot Study

  • Gema Santamaría,
  • Natalia Román Nieto,
  • Raúl Cobreros Mielgo,
  • Ana M. Celorrio San Miguel,
  • Luis M. Cacharro,
  • Juan F. Mielgo-Ayuso and
  • Diego Fernández-Lázaro

23 February 2026

Background/Objectives: Walking impairment and fatigue are common in multiple sclerosis (MS) and contribute to reduced physical function and quality of life (QoL). This study evaluated the feasibility, safety, and pre–post changes associated wit...

  • Article
  • Open Access
14 Citations
7,335 Views
18 Pages

Characteristics of Preliminary Breakdown Pulses in Positive Ground Flashes during Summer Thunderstorms in Sweden

  • Dalina Johari,
  • Vernon Cooray,
  • Mahbubur Rahman,
  • Pasan Hettiarachchi and
  • Mohd Muzafar Ismail

10 March 2016

This paper presents the characteristics of the preliminary breakdown pulses (PBP) in 51 positive ground flashes recorded during 2014 summer thunderstorms in Sweden. Electric field measurements were conducted remotely using a broadband antenna system...

  • Article
  • Open Access
4 Citations
2,193 Views
20 Pages

Distributed Cooperative Cruise Control for High-Speed Trains with Energy-Saving Optimization

  • Feng Zhou,
  • Kewu Tao,
  • Bin Chen,
  • Shuo Li,
  • Zhengfa Zhu and
  • Yingze Yang

17 May 2023

With the aim of improving the energy utilization during the cooperative operation of multiple trains, this paper proposes an optimal distributed cooperative cruise control strategy to ensure safe and efficient tracking. A performance index function w...

  • Review
  • Open Access
43 Citations
7,228 Views
21 Pages

12 November 2021

Background: Evidence indicates that exercise holds the potential to counteract neurodegeneration experienced by persons with multiple sclerosis (pwMS), which is in part believed to be mediated through increases in neurotrophic factors. There is a nee...

  • Article
  • Open Access
2 Citations
1,858 Views
17 Pages

Which Variables Are Associated with the Magnitude of the Physical Fitness Response in Older Adults? An Analysis of Their Development and Influence

  • Andressa Crystine da Silva Sobrinho,
  • Larissa Chacon Finzeto,
  • Mariana Luciano de Almeida,
  • Guilherme da Silva Rodrigues,
  • João Gabriel Ribeiro de Lima,
  • Karine Pereira Rodrigues,
  • Átila Alexandre Trapé,
  • Lais Prado and
  • Carlos Roberto Bueno Júnior

Regular physical exercise has proven to be an effective strategy for enhancing the health and well-being of older adults. However, there are still gaps in our understanding of the impacts of exercise on older adults with different health conditions,...

  • Proceeding Paper
  • Open Access
3 Citations
2,287 Views
4 Pages

Depression is one of the most prevalent mental health diseases. Although there are effective treatments, the main problem relies on providing early and effective risk detection. Medical experts use self-reporting questionnaires to elaborate their dia...

  • Article
  • Open Access
1,304 Views
17 Pages

Numerical Study on Smoke Characteristics in Ultra-Long Tunnels with Multi-Train Fire Scenarios

  • Jiaming Zhao,
  • Cheng Zhang,
  • Saiya Feng,
  • Shiyi Chen,
  • Guanhong He,
  • Yanlong Li,
  • Zhisheng Xu and
  • Wenbin Wei

3 July 2025

Metropolitan city express line tunnels are fully enclosed and often span long distances between stations, allowing multiple trains within a single interval. Traditional segmented ventilation ensures only one train per section, but ultra-long tunnels...

  • Article
  • Open Access
408 Views
20 Pages

A Real-Time Dynamic Warning Method for MODS in Trauma Sepsis Patients Based on a Pre-Trained Transfer Learning Algorithm

  • Jiahe Wen,
  • Guanjun Liu,
  • Panpan Chang,
  • Pan Hu,
  • Bin Liu,
  • Chunliang Jiang,
  • Xiaoyun Xu,
  • Jun Ma and
  • Guang Zhang

Objectives: Multiple organ dysfunction syndrome (MODS) is a serious, prognostically poor complication in trauma sepsis. We developed an interpretable, multicenter-validated prediction model to enable early, individualized risk assessment and guide ti...

  • Brief Report
  • Open Access
7 Citations
2,398 Views
6 Pages

Enhancing the Quality of Life of Patients with Multiple Sclerosis: Promising Results on the Role of Cognitive Tele-Rehabilitation Plus Virtual Reality

  • Maria Grazia Maggio,
  • Antonino Cannavò,
  • Angelo Quartarone,
  • Alfredo Manuli,
  • Paolo Tonin and
  • Rocco Salvatore Calabrò

25 November 2023

(1) Background: Patients with multiple sclerosis often face obstacles accessing traditional rehabilitation programs, primarily due to mobility limitations. Tele-rehabilitation (TR) is seen as a promising solution to overcome these barriers, though it...

  • Article
  • Open Access
1 Citations
3,122 Views
17 Pages

Objectives: Single-case experimental designs (SCEDs) provide a robust way to observe adaptations to training in highly specific populations. Furthermore, they provide unique insights into inter-participant variance in responses to interventions, whic...

  • Article
  • Open Access
2,433 Views
14 Pages

The Role of VibraPlus on Fatigue in Multiple Sclerosis Patients: A Randomized Controlled Trial

  • Caterina Formica,
  • Desirée Latella,
  • Lilla Bonanno,
  • Antonino Lombardo Facciale,
  • Giuseppe Paladina,
  • Antonino Leo,
  • Luca Pergolizzi,
  • Bartolo Fonti,
  • Angelo Quartarone and
  • Rocco Salvatore Calabrò
  • + 1 author

5 June 2025

Background and Objective: Fatigue represents a hallmark symptom in Multiple Sclerosis (MS), but its diagnosis and clinical evaluation is difficult because it is described as a subjective feeling of exhausted physical and mental sensation. Studies hav...

  • Article
  • Open Access
11 Citations
6,243 Views
11 Pages

Twelve Weeks of Medium-Intensity Exercise Therapy Affects the Lipoprotein Profile of Multiple Sclerosis Patients

  • Winde Jorissen,
  • Tim Vanmierlo,
  • Inez Wens,
  • Veerle Somers,
  • Bart Van Wijmeersch,
  • Jeroen F. Bogie,
  • Alan T. Remaley,
  • Bert O. Eijnde and
  • Jerome J. A. Hendriks

Multiple sclerosis (MS) is an inflammatory auto-immune disease of the central nervous system (CNS). Serum glucose alterations and impaired glucose tolerance (IGT) are reported in MS patients, and are commonly associated with the development of cardio...

  • Review
  • Open Access
3 Citations
5,554 Views
14 Pages

3 April 2022

Cognitive impairment is a common and detrimental consequence of multiple sclerosis (MS) and current rehabilitation methods are insufficient. Cognitive rehabilitation (CR) and exercise training (ET) are the most promising behavioral approaches to miti...

  • Article
  • Open Access
13 Citations
3,004 Views
11 Pages

2 February 2023

This study aimed to compare and associate the magnitude of the load–velocity relationship variables between the multiple-point and two-point methods and between the concentric-only and eccentric–concentric prone bench pull (PBP) variants....

  • Article
  • Open Access
35 Citations
6,095 Views
19 Pages

28 September 2022

To solve the problems of autonomous decision making and the cooperative operation of multiple unmanned combat aerial vehicles (UCAVs) in beyond-visual-range air combat, this paper proposes an air combat decision-making method that is based on a multi...

  • Article
  • Open Access
7 Citations
3,342 Views
19 Pages

6 August 2020

Reservoir heterogeneity is a key geological problem that restricts oil and gas exploration and development of clastic rocks from the early to late stages. Existing reservoir heterogeneity modeling methods such as multiple-point geostatistics (MPS) ca...

  • Article
  • Open Access
3 Citations
2,633 Views
19 Pages

3 November 2022

The driver scheduling problem at Chinese electric multiple-unit train depots becomes more and more difficult in practice and is studied in very little research. This paper focuses on defining, modeling, and solving the depot driver scheduling problem...

  • Article
  • Open Access
7 Citations
3,761 Views
14 Pages

This study aimed to determine cortical activation responses to two different rehabilitative programs, as measured through functional near-infrared spectroscopy (fNIRS). As a secondary analysis of the RAGTIME trial, we studied 24 patients with progres...

  • Article
  • Open Access
7 Citations
4,873 Views
16 Pages

31 January 2023

Weather variation in the distribution of image data can cause a decline in the performance of existing visual algorithms during evaluation. Adding additional samples of target domain to training data or using pre-trained image restoration methods suc...

  • Article
  • Open Access
9 Citations
3,642 Views
13 Pages

Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)?

  • Arianna Di Stadio,
  • Evanthia Bernitsas,
  • Ignazio La Mantia,
  • Michael J. Brenner,
  • Massimo Ralli,
  • Luigi Angelo Vaira,
  • Andrea Colizza,
  • Carlo Cavaliere,
  • Matteo Laudani and
  • Marta Altieri
  • + 3 authors

13 January 2023

Chronic olfactory dysfunction after SARS-CoV-2 infection occurs in approximately 10% of patients with COVID-19-induced anosmia, and it is a growing public health concern. A regimen of olfactory training and anti-neuroinflammatory therapy with co-ultr...

  • Study Protocol
  • Open Access
1 Citations
1,664 Views
15 Pages

HIITing Anxiety and Depression in Parkinson’s Disease and Multiple Sclerosis—A Study Protocol of a Transdiagnostic Randomized Controlled Trial (HersenFIT)

  • Arianne S. Gravesteijn,
  • Marc B. Rietberg,
  • Vincent de Groot,
  • Mark A. Hirsch,
  • Tim Vanbellingen,
  • Richard T. Jaspers,
  • Chris Vriend,
  • Wilma D. J. van de Berg,
  • Odile A. van den Heuvel and
  • on behalf of the HersenFIT Consortium
  • + 1 author

29 August 2025

Background/Objectives: Parkinson’s disease (PD) and multiple sclerosis (MS) are neurological conditions that result in debilitating non-motor symptoms, such as anxiety and depression, which significantly reduce quality of life and often persist...

  • Article
  • Open Access
2 Citations
2,409 Views
15 Pages

Perceptions of Therapeutic Climbing for Patients with Multiple Sclerosis in Neurorehabilitation: A Qualitative Study

  • Tobias Schiffler,
  • Eva Reiter,
  • Ali Kapan,
  • Gottfried Kranz,
  • Stefan Thomas Kotzian and
  • Sandra Haider

Background: Therapeutic climbing (TC) has emerged as a prospective rehabilitation approach for individuals with multiple sclerosis (MS). The existing literature primarily focuses on the physical and psychological benefits of TC across diverse populat...

  • Article
  • Open Access
1 Citations
6,039 Views
17 Pages

26 December 2016

Hybrid propulsion systems allow for a reduction of fuel consumption and pollutant emissions of future off-highway applications. A challenging aspect of a hybridization is the larger number of system components that further increases both the complexi...

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