Analytical biosimilarity assessment relies on two implicit conditions. First, the analytical method must meet a set of requirements known as fit for intended use related to trueness and precision. Second, the manufacture of the reference drug product...
In addition to the analytical challenges related to the size and complexity of biopharmaceutical drugs, the inherent variability that arises due to their manufacturing process requires monitoring throughout the production process to ensure the safety...
Silicon-based vertical double-diffused MOSFET (VDMOS) devices are important components of the power system of spacecraft. However, VDMOS is sensitive to the total ionizing dose (TID) effect and may have TID response variability. The within-batch TID...
Background: The manufacture of biologics is a complex, controlled, and reproducible process that results in a product that meets specifications. This should be based on data from batches used to demonstrate manufacturing consistency. Ten batches of o...
The preparation of water-bearing regolith analogues supports laboratory investigations relevant to lunar polar exploration. This study investigates a flow-field overlap method in which mechanically agitated regolith particles are exposed to water vap...
The physical and mechanical performance of mortars incorporating waste marble powder (WMP) depends on powder characteristics and mixture design, whereas conditioning energy influences environmental impact. This study examined 0, 5, 10, and 15% cement...
The increase in prolificacy at weaning is less than that at farrowing due to increased loss of piglets. As a result, farmers focus more on solutions that can prevent difficult parturition or a decrease in milk production. The body condition of the so...
Acceptance sampling plans are divided into attributes and variables, which are used to evaluate the mechanism for determining lot quality. Traditional attribute sampling plans usually choose the Acceptable Quality Level (AQL) for each stage based on...
The consumer rejection threshold (RjT) method was applied to determine the total microbial numbers (TMNs) where consumers find that the quality of whole fresh chilled pasteurised milk (WFCPM) and skim milk (Trim) stored at 4.5 ± 0.5 °C is...
Interpretable machine learning for ordinal quality grading faces a fundamental tension between model transparency and predictive performance, particularly under small-data conditions where end-to-end deep learning is unreliable and domain knowledge m...
Sperm quality influences bovine in vitro embryo production (IVEP). Linear regression is a statistical tool that models the relationship between a dependent variable and one or more independent variables. It can be used to predict outcomes, analyze tr...
Task allocation is a critical issue of spatial crowdsourcing. Although the batching strategy performs better than the real-time matching mode, it still has the following two drawbacks: (1) Because the granularity of the batch size set obtained by bat...
As industrial informatization progresses, virtual simulation technologies are increasingly demonstrating their potential in industrial applications. These systems utilize various sensors to capture real-time factory data, which are then transmitted t...
This article addresses an integrated problem of one batching and two scheduling decisions between a manufacturing plant and multi-delivery sites. In this problem, two scheduling problems and one batching problem must be simultaneously determined. In...
Saccharomyces cerevisiae var. boulardii is a probiotic yeast widely recognized for its ability to enhance gut health and modulate a host’s microbiome. However, there are limited data on its large-scale cultivation in stirred tank bioreactors an...
This study examined relevant variables for predicting the prevalence of pigs with a tail lesion in rearing (REA) and fattening (FAT). Tail lesions were recorded at two scoring days a week in six pens in both REA (10 batches, 840 scoring days) and FAT...
Background: Exome (ES) and genome sequencing (GS) are powerful tools for diagnosing neurodevelopmental disorders (NDDs), yet sequencing coverage failures can leave clinically relevant variants undetected. Analyzing the distribution of coverage gaps a...
“Torta del Casar” is a traditional Spanish cheese made from raw ewe’s milk under Protected Designation of Origin (PDO) regulations. Its unique characteristics result from the use of vegetable rennet and an abundant indigenous microb...
Background/Objectives: Only a few studies performed at industrial scale in non-simulated conditions have investigated the effect of input variability from the product’s lifecycle on product quality. The purpose of this work was to identify the...
Brassica rapa, commonly known as the rapeseed plant, is globally recognized for its nutrient-rich composition and oil-packed seeds, earning its distinction as a substantial oil-seed crop. The seed quality, particularly the germination rate, is instru...
The impregnation of elements made of wood is one of the most important stages of their maintenance and the modification of their parameters. Incorrectly prepared material is sensitive to moisture, fungi, algae or weather conditions. In the case of la...
Silver nanoparticles (AgNPs) are extensively employed for their antimicrobial and biomedical properties, yet concerns persist regarding their potential toxicity. While AgNPs can induce oxidative stress, membrane disruption, and DNA damage, in vivo da...
The long test cycle and high cost of generating composite design allowables constrain the development of low-altitude aircraft. This study investigates a calculation method for single-batch, small-sample B-basis values of multidirectional laminates....
We characterized 202 Japanese apricot (Prunus mume) accessions using 480 accession-year records collected from 2024 to 2026. We calculated a Gower distance in which each of the 15 variables recorded annually was weighted by its between-year reproduci...
The current study evaluated the effects of different levels of inclusion of ensiled pomegranate by-product (PS: 0, 5, 10, and 15% DM) into the diet of lactating dairy goats on production performance and metabolic status. Seventy-two Murciano-Granadin...
IMUNOR is an oral biotherapeutic drug that had been developed, registered, and approved in 1997 in the Czech Republic and Slovakia. IMUNOR is a dialyzable leukocyte extract (DLE) prepared from swine leukocytes. It is characterized as a mixture of sma...
Black soldier fly (Hermetia illucens) larvae are increasingly used as sustainable feed resources, and recent studies have expanded knowledge of their lipid fraction. This study characterized a single batch of mechanically extracted unrefined black so...
Advancements in intelligent manufacturing require solutions to the conventional flexible job-shop scheduling problem (FJSP) to accommodate increasingly intricate constraints, particularly in the semiconductor and electronic component sectors, where b...
Planning and managing the production process are key challenges faced by every manufacturing organization. The main contribution of this article lies in the analysis and design of a planning algorithm that takes into consideration the specifics of th...
The sweet protein thaumatin is emerging as a promising sugar replacer in the market today, especially in the food and beverage sector. Rising demand for its production necessitates the large-scale extraction of this protein from its natural plant sou...
Road traffic injuries remain a central challenge for sustainable transport, public health, and mobility governance. The task of monitoring these injuries requires indicators that jointly capture harm severity, road and environmental context, and patt...
Bovine brucellosis is an endemic zoonotic disease in South Africa with significant consequences for livestock productivity and public health. Although routine laboratory surveillance data from the Rose Bengal Test (RBT) are widely collected, they are...
Automating the pushing of bulk materials deposited through the hatch of a transport and packaging container (TPC) requires the development of a specialized robot equipped with an end effector capable of displacing material within a spatially constrai...
Tyre mass contributes to unsprung mass, rotating inertia, and broader vehicle-related characteristics, yet manufacturing mass variability among nominally identical passenger-car tyres remains comparatively insufficiently documented experimentally. Th...
Calcium carbonate (CaCO3) is one of the most abundant substances on earth and has a large array of industrial applications. Considerable research has been conducted in an effort to synthesize calcium carbonate microparticles with controllable and spe...
Currently, companies are called to meet variable market demand whilst having to comply with tighter delivery times, also due to the growing spread of e-commerce systems in the last decade. As never before, it is therefore mandatory to increase the ef...
The bacterial communities that are established during natural meat fermentation depend on the processing conditions and the type of meat substrate used. Six pork samples of variable quality (reflected in pH values) and six less conventional meats (be...
Contactless palmprint verification must generalize to unseen identities while remaining robust to variations in hand pose, scale, illumination, camera distance, and background. This study presents a cosine-consistent deep metric-learning framework co...
Being a biopharmaceutics classification system class II drug, the absorption of sertraline from the gut is mainly limited by its poor aqueous solubility. The objective of this investigation was to improve the solubility of sertraline utilizing self-n...
3D organoid model technologies have led to the development of innovative tools for cancer precision medicine. Yet, the gold standard culture system (Matrigel®) lacks the ability for extensive biophysical manipulation needed to model various cance...
High cell density (HCD) fed-batch cultures are widely perceived as a requisite for high-productivity polyhydroxyalkanoate (PHA) cultivation processes. In this work, a reactive pulse feed strategy (based on real-time CO2 or dissolved oxygen (DO) measu...
This study explains about a serial smart production system where a single-type of product is produced. This system uses an unequally sized batch policy in subsequent stages. The setup cost is not always deterministic, it can be controllable and reduc...
Insect farming is gaining momentum for its potential to strengthen food security and the sustainability of food systems. However, how rearing conditions shape the overall quality of edible insects remains poorly understood. Optimization strategies ar...
Investigation and quality assessment of veterinary orthopaedic implants are seldom undertaken, despite their critical role in clinical outcomes. Dimensional accuracy is particularly important for screw–bone interface stability. This study aimed...
Antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) have transformed human immunodeficiency virus (HIV) treatment and prevention, but both depend on sustained adherence and accurate drug-exposure monitoring. Liquid chromatography-tandem...
The kidney is an essential organ that has a crucial role in preserving homeostasis within the human body. Kidney cancer is considered a major clinical challenge owing to its resistance to traditional treatments such as chemotherapy, radiotherapy, and...
Cow milk adulteration in plant-based milk alternatives (PBMAs) raises authenticity and safety concerns, particularly for consumers with dairy allergies or lactose intolerance. This study evaluated the laboratory-scale feasibility of excitation–...
This work addresses the problems of uniquely specifying and robustly achieving user-specified product quality in a complex industrial batch process, which has been demonstrated using a lab-scale uni-axial rotational molding process. In particular, a...
Aflatoxins (AFs) remain the main concern for the agricultural and dairy industries due to their effects on the performances and quality of livestock production. Aflatoxins are always unavoidable and should be monitored. The objective of this paper is...
The significant microbiota variability represents a key feature that makes the full comprehension of the functional interaction between microbiota and the host an ongoing challenge. To overcome this limitation, in this study, fish intestinal microbio...
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