Chromatographic and Electrophoretic Methods in Current Biomedical Analysis

Dear Colleagues,

Chromatographic techniques, such as liquid and gas chromatography (LC and GC, respectively), are the most frequently used analytical techniques implemented in a wide range of different practical areas due to their universality concerning analyzed compounds, ability to be hyphenated with various universal as well as selective detection techniques, and outstanding separation ability. Undoubtedly, the great progress in chromatography instrumentation and methodology is related to its high degree of commercialization. On the other hand, capillary electrophoretic (CE) techniques represent a flexible, simple, and economic tool in current analysis, alternative to chromatography. CE techniques are naturally suited for ionic or ionizable compounds and are therefore the first choice when considering acidic or basic low molecular compounds, as well as peptide-, protein- or oligo/polynucleotide-based poly-ionic compounds. Advances in the development of both chromatographic and electrophoretic techniques (e.g., UHPLC, SFC, CEC, EKC, chiral systems, 2D systems, hyphenations with MS, LIF) enable enhancing their analytical and application possibilities substantially. Thus, new innovative methods can be implemented in solving even the most demanding practical tasks. This Special Issue is aimed at the presentation of recent advances in biomedical analysis, including all aspects of method development, validation, and practical implementation. Innovative methods for model analyses as well as conventional methods applied to solve current problems are highly encouraged. From an application point of view, drug model studies (e.g., enantiomeric separations with new chiral selectors), clinical drug monitoring (e.g., metabolic and pharmacokinetic studies), quality drug control (e.g., identification and determination of drug impurities in pharmaceuticals), monitoring of potential biomarkers (targeted, untargeted, profiling), and other related examples (involving other interesting biologically active compounds, new potential drugs, toxins, substances of abuse, drug residues, etc.), are strongly encouraged to be submitted.

Prof. Dr. Peter Mikuš
Guest Editor

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