1,982 Results Found

The programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) is an immune checkpoint (ICP) overexpressed in various types of tumors; thus, it has been considered as an important target for cancer therapy. To determine important r...

The unique minerals of the Au-Pd-Hg system in gold grains from heavy concentrates of the Itchayvayam placers and watercourses draining and ore samples of the Barany outcrop at the Itchayvayam mafic–ultramafic complex (Kamchatka, Russia) were in...

This study aims to investigate the effect of the Pd(II) complex on HeLa cells using computational biology and proteomic analysis. [Pd(dach)Cl₂]-treated HeLa cells were subjected to comparative proteomics analysis using label-free data-independent liq...

This article examines the performance of the proposed complex-order, conventional and fractional-order controllers for process automation and control in process plants. The controllers are compared regarding disturbance rejection and set-point tracki...

Growing tumors avoid recognition and destruction by the immune system. During continuous stimulation of tumor-infiltrating lymphocytes (TILs) by tumors, TILs become functionally exhausted; thus, they become unable to kill tumor cells and to produce c...

The square planar complex [Pd(PT)Cl(H₂O)]*H₂O (HPT: 6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine-2,4(1H,3H)-dione) was obtained by the reaction of 2-methoxy-4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine (MBPT) pincer ligand with PdCl₂ in a...

Highly atypical mineralization involving Pd-Pt, Au-Ag, REE, Y, Zr, U, Th, and Cl-F-enriched minerals is found in zones with base metal sulfides (BMS; ~5 vol.% to 20 vol.%) in the eastern portion of the Oktyabrsky deposit in the Norilsk complex (Russi...

c-MYC is overexpressed in 70% of human cancers, including triple-negative breast cancer (TNBC), yet there is no clinically approved drug that directly targets it. Here, we engineered the mRNA-stabilizing poly U sequences within the 3′UTR of c-M...

We engineered a compact methanol steam reforming (MSR) system tailored to power a 1 kW High-Temperature Proton Exchange Membrane (HT-PEM) fuel cell. The unit integrates an evaporator, reformer, and burner within a cylindrical titanium-alloy vacuum fl...

Formation of mixed-ligand Pd²⁺ complexes between canonical nucleoside 5'-monophosphates and five metal-ion-binding nucleoside analogs has been studied by ¹H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between...

This review article presents an overview of the equilibrium studies on Pd-amine complexes with bio-relevant ligands in reference to their antitumor activity. Pd(II) complexes with amines of different functional groups, were synthesized and characteri...

Background/Objectives: Cancer remains a major global health challenge, driving the search for novel chemotherapeutic agents. This study aimed to evaluate the structural and biological properties of a series of Pd(II) complexes containing triphenylpho...

The anti-PD-L1 monoclonal antibody (mAb) targeting PD-1/PD-L1 immune checkpoint has achieved outstanding results in clinical application and has become one of the most popular anti-cancer drugs. The mechanism of molecular recognition and inhibition o...

Chemical, pharmacological, and clinical research on anticancer coordination complexes has led to noteworthy anticancer drugs such as cisplatin, carboplatin and oxaliplatin. Although these compounds are effective chemotherapeutic agents in the treatme...

Formation of PdIn intermetallic nanoparticles supported on α-Al₂O₃ was investigated by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), and hydrogen temperature-programmed desorption (H₂-TPD) methods. The metals were load...

Two bis-(imidazolium–vanillylidene)-(R,R)-diaminocyclohexane ligands (H₂(VAN)₂dach, H₂L_1,2) and their Pd(II) complexes (PdL₁ and PdL₂) were successfully synthesized and structurally characterized using microanalytical and spectral methods. Subs...

We herein report on the synthesis and structural characterization, as well as on the photophysical properties, of a series of isoleptic Pt(II) and Pd(II) complexes featuring tridentate N^N^N chelators as luminophores while bearing diverse ancillary c...

We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscop...

Metalloporphyrins (and porphyrins) are well known as pigments of life in nature, since representatives of this group include chlorophylls (Mg-porphyrins) and heme (Fe-porphyrins). Hence, the construction of chemistry based on these substances can be...

Background: The newly synthesized palladium(II) complex [Pd(L1)Cl]Cl (where L1 = N²,N⁶-bis(5-methylhthiazol-2-yl)pyridine-2,6-dicarboxamide) has demonstrated significant in vitro antitumor activity. In this study, the effects of this complex on the i...

N-heterocyclic carbenes (NHCs) can be easily modified by introducing functional groups at the nitrogen atoms, which leads to versatile coordination chemistry as well as diverse catalytic applications of the resulting complexes. This article summarize...

This review focuses on some interesting and recent applications of transition metals towards the complexation of thiosemicarbazides, thiocarbohydrazides, and their corresponding carbazones. We started the review with a description of the chosen five...

Binuclear diaminocarbene complexes, which form as a regioisomer mixture in the reaction between isocyanide–palladium(II) complex cis-[PdCl₂(CNXyl)₂] and 1,3-thiazol-2-amine, are able to exchange an anionic chloride ligand with other halides, su...

Rapid advancements in understanding how the immune system can eliminate tumors have quickly translated into breakthroughs in developing cancer therapeutics. Immune checkpoint inhibitors (ICIs) have shown great promise in several cancers; however, res...

The study of the reactivity of three 2-phenyl-3H-indole ligands of general formulae C₈H₃N-2-(C₆H₄-4-R¹)-3-NOMe-5-R² (1) [with R¹ = H, R² = OMe (a); R¹ = R² = H (b) or R¹ = Cl, R² = H (c)] with [Pd(η³-1-R³C₃H₄)(μ-Cl)]₂ (R³ = H or Ph) has allowe...

N-heterocyclic carbene (NHC) precursors (2a–i), their pyridine-enhanced precatalyst preparation stabilization and initiation (PEPPSI)-themed palladium N-heterocyclic carbene complexes (3a–i) and palladium N-heterocyclic triphenylphosphine...

The [Ru(PPh₃)₂Cl-piperidine(4-aminomethyl)] complex (mono-Ru) was synthesized from [Ru(PPh₃)₃Cl₂] and 4-(aminomethyl)piperidine, whereas the [(PPh₃)PdCl(Shiff-pip)] complex (mono-Pd) was obtained by reacting [Pd(PPh₃)₂Cl₂] with its respective Schiff...

The present study reports the sono-chemical synthesis of novel nanosized Cr(III), Mn(II), and Pd(II) complexes incorporating the chloro-2-(quinolin-8-yliminomethyl)-phenol imine ligand. The synthesized complexes were characterized using various spect...

The relativistic effects of the values of the shielding constants of ¹H, ¹³C, ¹⁵N, ⁵⁷Fe, ⁵⁹Co, ⁶¹Ni, ¹⁰⁵Pd, and ¹⁹⁵Pt nuclei were studied at the four-component relativistic level and were compared to the results of non-relativistic calculations perfo...

The PD-1/PD-L1 pathway blockade can generate a good clinical response by reducing immunosuppression and provoking durable antitumor immunity. In addition to antibodies, aptamers can also block the interaction between PD-1 and PD-L1. For the in vivo a...

A derivative UV-spectrophotometric method was developed for the analysis of two halogenated 8-hydroxyquinoline derivatives; iodochlorohyroxyquin (I) (Clioquinol) and diiodohydroxyquin (II) (iodoquinol). The proposed method depends on the formation of...

The synthesis and characterization of the tripodal phosphines RSi(CH₂CH₂PPh₂)₃ (R = Me, OMe, OEt) (1–3) is described. The ¹H NMR spectra of all phosphines display virtual coupling patterns. The ligands form the corresponding trinuclear Pd compl...

Two novel carbohydrate-derived pyridyl (PYOX)- and cyclopropyl (CYBOX)-substituted oxazoline ligands were prepared from d-glucosamine hydrochloride and 1,3,4,6-tetra-O-acetyl-2-amino-2-deoxy-β-d-glucopyranose hydrochloride in two steps, respectively....

The study of noble metal minerals of the Ural–Alaskan-type (UA-type) complexes has been traditionally focused on their platinum-bearing dunites and chromitites, while clinopyroxenites have been poorly considered. In this study, we report the fi...

Parkinson’s disease Multimodal Complex Treatment (PD-MCT) is a multidisciplinary inpatient treatment approach that has been demonstrated to improve motor function and quality of life in patients with Parkinson’s disease (PD). In this stud...

Cancer immunotherapy has revolutionized the way different neoplasms are treated. Among the different variations of cancer immunotherapy, the checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1)...

During the first meiotic prophase, the cohesin complex is localized to the chromosome axis and contributes to chromosome organization, pairing, synapsis, and recombination. The PDS5 protein, an accessory factor of the cohesin complex, is known to be...

This work describes the synthesis of eight new Pd(II) and Pt(II) complexes with the general formula [M(TSC)Cl], where TSC represents the 4N-monosubstituted thiosemicarbazone derived from 2-acetylpyridine N-oxide with the substituents CH₃ (H4MLO), C₂H...

The selective determination of metals in waste solutions is a very important aspect of the industry and environmental protection. Knowledge of the contents and composition of the waste can contribute to design an efficient process separation and reco...

For the creation of adaptable carbonyl compounds in organic synthesis, the oxidation of alcohols is a crucial step. As a sustainable alternative to the harmful traditional oxidation processes, transition-metal catalysts have recently attracted a lot...

Nitrogen donor-based ligands are highly promising extractants for palladium separation from high-level liquid waste (HLLW). However, the electronic effect of these ligands, a critical factor influencing their complexation ability with Pd(II), remains...

Indirect reductive amination of aldehydes, catalyzed by polymer supported triphenylphosphine-palladium acetate complex PS-TPP-Pd(OAc)₂ catalyst have been developed. The imine is prepared with molecular sieves in the first stage, followed by reduction...

Herein, we described the synthesis and X-ray crystal structure of the new [Pd(3)₂Cl₂] complex with 1,2,3-triazole-based ligand (3). In the unit cell, there are two [Pd(3)₂Cl₂] molecules, and the asymmetric unit comprised half of this formula due to t...

Pd(II) with the Schiff base ligand 2-Hydroxy-3-Methoxy Benzaldehyde-Thiosemicarbazone (HMBATSC) (L2) and 2-aminobenzothiazole (2-ABZ) (L1) was synthesized. The Schiff base ligand and the Palladium(II) complex were characterized by C.H.N.S, FT-IR, con...

The synthesis of analogs of cisplatin, which is a widely used chemotherapeutic agent, using other metal centers could be an alternative for cancer treatment. Pd(II) could be a substitute for Pt(II) due to its coordination chemistry similarity. For th...

The synthesis and X-ray structure analysis of the new [PdLCl₂]*0.5 CH₂Cl₂ complex where L is hydrazono-s-triazine di-morpholine derivative, were presented. In the neutral inner sphere of this complex, the organic ligand L is acting as a NN-bidentate...

A tandem UV–Vis and fluorescence spectroscopy method was developed for the detection of Pd(II) ions in ethanol. The formation of a complex between Pd(II) ions and tropaeolin OO (TR OO) is accompanied by a change in the color of the solution and...

Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd₂Spm), which has p...

The current research describes the synthesis and characterization of 2-acetylpyridine N(4)-cyclohexyl-thiosemicarbazone ligand (HL) and their two metal complexes, [Au(L)Cl][AuCl₂] (1) and [Pd(L)Cl]·DMF (2). The molecular structures of the comp...

In this work, we report synthesis, crystallographic, spectroscopic and quantum chemical studies of a new imine oxime, namely (4-nitro-phenyl)-(1-phenyl-ethylimino)-acetaldehyde oxime (nppeieoH). Spectroscopic and X-ray diffraction studies showed that...