Next Article in Journal
Analysis of the Essential Oil of the Aerial Parts of the Medicinal Plant Aristolochia indica Linn. (Aristolochiaceae) from South-India
Previous Article in Journal
Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle

Derivative UV Spectrophotometric Analysis of Some Pharmaceutically Important Halogenated 8-Hdroxyquinoline Derivatives via Their Pd (II)-Complexes

Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2000, 68(3), 297-307; https://doi.org/10.3797/scipharm.aut-00-27
Received: 9 May 2000 / Revised: 21 August 2000 / Accepted: 21 August 2000 / Published: 24 August 2000
A derivative UV-spectrophotometric method was developed for the analysis of two halogenated 8-hydroxyquinoline derivatives; iodochlorohyroxyquin (I) (Clioquinol) and diiodohydroxyquin (II) (iodoquinol). The proposed method depends on the formation of Pd II-ligand complexes in methanol-acetonitrile mixture, which exhibits an UV-spectra with an appreciable value of ε. Zero order (0D), first order (1D) and fourth order (4D) derivative measurements were applied for the quantitative analysis of the drugs. A linear correlation was established between absorbance and concentration for the 0D mode in the range 2-14µg ml-1 and 2-18 µg ml-1 for (I) and (II) with average % recoveries of 99.83 ± 1.04 and 99.9 ± 0.64 respectively. Also a linear correlation was obtained between the trough of the peak and concentration for 1D mode in the range of 0.16-0.8 µgml-1 for both dmgs with average % recoveries of 100.23 ± 1.04 and 100.18 ± 1.14 for (I) and (II) respectively. Besides, the 1D mode was successfully applied for the analysis of binary mixture containing both (II) and metronidazole (III) in tablet formulations. The average % recoveries were 99.42 ± 0.358 and 98.81 ± 0.973 for (II) and (III) respectively. In the 4D mode, a linear correlation was attained between the amplitude of the peak and concentration in the range 0.1-0.8 µgml-1 for (I) and (II), with average % recoveries of 99.6 ± 0.84 and 100.06 ± 0.98. The limit of detection (LOD) was 2.1 µg ml-1 and 2.3 µg ml-1 for (I) and (II) respectively. The suggested method was successfully applied for accurate, sensitive and selective analysis of the studied drugs in bulk and single or combined dosage forms with average % recoveries of 99.74 ± 0.480–99.84 ± 0.515 and 99.44 ± 0.71–100.58 ± 1.06 for (1D) and (4D) respectively. The results obtained were favorably compared to those given by a reference method.
Keywords: Derivative spectrophotometry; halogenated 8-hydroxyquinolines; Pd (II)-complexes; clioquinol; iodoquinol; dosage forms Derivative spectrophotometry; halogenated 8-hydroxyquinolines; Pd (II)-complexes; clioquinol; iodoquinol; dosage forms
MDPI and ACS Style

M., R.; F., B.; F., I.; S., A.; Z.A., S. Derivative UV Spectrophotometric Analysis of Some Pharmaceutically Important Halogenated 8-Hdroxyquinoline Derivatives via Their Pd (II)-Complexes. Sci. Pharm. 2000, 68, 297-307.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop